Abstract:This Small Business Innovation Research (SBIR) Phase I research project will develop a novel diagnostic test to detect Mycobacterium avium subsp. paratuberculosis (MAP). MAP is the causative agent of Johnes disease in cattle and, possibly, of human Crohns disease. A novel approach of early and… more
Abstract:Robust and reliable trace-gas analyzers (e.g., for isotopic carbon, methane, nitroxide, ammonia, etc.), suitable for long-term measurements, are not commercially available. Such analyzers are needed to achieve a better understanding of the global budget of these trace gases and to quantify their… more
Abstract:The commercial opportunities for products based on delicate biomolecules, such as enzymes and therapeutic proteins, are growing at a strong pace. However, many proteins of great commercial value, including enzymes, undergo loss of function on encapsulation, when approaches based on high-shear… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will explore the use of a material comprising a fibrous substrate and an inorganic adsorbent/catalytic coating for removal of toxic small linear molecules from smoke. Phase I research will focus on identification of an efficient… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project is a feasibility study for the design of true core-shell type nonocapsules for drug delivery. The research will focus on strategies aimed at controlling the nanostructure and chemistry of the capsules, and also on ways to design… more
Abstract:DESCRIPTION (provided by applicant): DNA vaccines and gene medicines, derived from bacterial plasmids, are emerging as an important new class of pharmaceuticals. DNA molecules made strictly by rational design allows the manufacturer to bypass years of development for the production of efficacious… more
Abstract:Keeping the Air Force assets flying is difficult enough at depot level where there are extensive facilities and expert help. But in an austere environment, these advantages aren't present. A recent innovation, the Portable Maintenance Aid (PMA), is a new type of tool to help the human through these… more
Abstract:The time and cost it takes to integrate new airborne weapons on platforms is still too great. The current F-15E Strike Eagle weapon integration timeline is 4 years, from requirements to fielding, and costs up to 20 million dollars. What is really needed for rapid aircraft-store integration is a… more
Abstract:The capability to correlate and integrate disparate information from heterogeneous intelligence sources that come with varying degrees of certainty and reliability is crucial for counter-terrorism operations (CTO). 21st Century Systems, Incorporated is pleased to propose continuing its successful… more
Abstract:Submarine commanders are currently hamstrung in tactical mission planning due to the limited capability to assess operational options in response to changes in the threat, environment, or assigned objectives. Current techniques to evaluate the assigned mission take little advantage of the recent… more
Abstract:In the realm of asymmetric threat detection, it is imperative to spot suspicious indicators in the ever-growing volume, variety, and complexity of data. It is recognized that quick detection of threats at the planning, attempting, and line formation stages is key and intelligence is crucial to… more
Abstract:The challenge of providing the sensor operator and tactical decision maker with all pertinent acoustic information and clues associated with any given contact has long eluded a solution. The technology to address this shortcoming is now available and we are pleased to have this opportunity to… more
Abstract:Software Agents and Agent Systems are steadily transitioning from small research projects to mainstream industrial and government markets. Multi-agent systems will live up to the expectations of implementing an openly-architected replacement of legacy stove-piped systems by providing flexible,… more
Abstract:Culturally diverse people are now participating in military multinational coalition applications as well as in extreme environments - once the province of American males drawn from a relatively homogenous cultural pool. Human biases and routines, capabilities and limitations strongly influence… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to use bioinformatics to transform complex data produced by comprehensive two-dimensional gas chromatography with mass spectrometry (GCxGC-MS) to usable chemical information. GCxGC-MS is an emerging technology for chemical… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes an innovative multiagent technology called the Intelligent Multiagent Infrastructure for Distributed Systems in Education (I-MINDS). In this system, the agents communicate and coordinate their actions to help support the… more
Abstract:78618S Robust and reliable trace-gas analyzers (e.g., for isotopic carbon, methane, nitroxide, ammonia, etc.), suitable for long-term measurements, are not commercially available. Such analyzers are needed to achieve a better understanding of the global budget of these trace gases and to quantify… more
Abstract:DESCRIPTION (provided by applicant):
We propose a new approach to single-molecule DMA sequencing that can be done in a simple microtiter plate fitted with two electrodes. Over two-hundred different single DMA molecules would be sequenced simultaneously in a single well (maximum 10 nt/s per… more
Abstract:DESCRIPTION (provided by applicant): Fluorescent molecules that are in close proximity to metallic surfaces, including silver and gold island films, produce increased fluorescence intensity along with increased photostability and decreased fluorescent lifetimes. These metal island films have been… more
Abstract:78011S Many industrial liquid-phase catalytic processes that require the use of some kind of active species (e.g. sensors, biosensors, chelating agents, and chemical traps) cannot be ¿heterogeneized¿ without significantly penalizing chemical activity and/or selectivity. Biphasic liquid media… more
Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR program is aimed at initiating a business venture dedicated to the manufacturing of nanoparticulates for toxicology research. The rate of nanotechnology R&D growth in the commercial, academic, and private sectors, appears to be outpaced only by… more
Abstract:DESCRIPTION (provided by applicant): Large scale manufacture of plasmid DNA is becoming increasingly important as the next generation of biotechnology products (gene medicines and DNA vaccines) make their way into clinical trials, and eventually into the pharmaceutical marketplace. Although… more
Abstract:The objective of this proposal is to develop a new and affordable resin that is curable and has a low viscosity at ambient temperature when used in the fabrication of fiberglass reinforced composite articles. The article, a 48"x48"x0.25" fiberglass fabric (24 ounces per square yard), will be… more
Abstract:DESCRIPTION (provided by applicant): Otoreflectance (OR) is a new class of hearing-test instruments utilizing acoustic signals presented and recorded in the ear canal. OR instruments address the following limitations in existing instruments to screen and diagnose middle-ear function: (1) detection… more
Abstract:DESCRIPTION (provided by applicant): The transplantation of heart grafts can dramatically provide a long and productive life to recipients with heart failure. Typical transplant survivals are more than 10 years. Because of an acute shortage of human donors, however, most do not receive their needed… more
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