Abstract:DESCRIPTION (provided by applicant): Malignant gliomas represent a heterogeneous family of tumors that are poorly responsive to current treatments. A major obstacle to the effective management of these lesions involves the difficulty in delivering adequateconcentrations of therapeutics to the tumor… more
Abstract:DESCRIPTION (provided by applicant): Plasmid-directed gene expression is now near the efficacy barrier that to date has prevented commercialization of plasmid-based therapies for human health applications. Previous innovations such as electroporation (EP)increased transgene expression through more… more
Abstract:DESCRIPTION (provided by applicant): An unmet need in the treatment of allergic asthma is an effective therapeutic strategy that focuses on an underlying cause of the disease rather than merely treating or managing its symptoms. At least one well- accepted underlying contributor to the… more
Abstract:This Small Business Innovation Research Phase I project will attempt to resolve inefficiencies in the processing of health insurance claims. A total of 8.3-18.1 billion transactions, including eligibility verification, claim submission, etc., are performed annually in healthcare with only 30-50% of… more
Abstract:Navy ships require the use of hazardous materials (HM) such as hydraulic fluid, paint, acids, corrosives, etc. for daily operations. Navy safety regulations and HM management procedure (i.e. OPNAVINST 5100.19E and CHRMIP), require designated HM storerooms for bulk storage of flammable and corrosive… more
Abstract:Our proposal is to develop SCADA Hawk: an integrated anti-tamper technology that uses a hardware-software combined methodology for the observational monitoring of existing systems with selective reaction capabilities. By enabling detailed monitoring capabilities our goal is to isolate anomalies in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I research project focuses on the demonstrating the technical feasibility and a commercialization path for a well-established educational robotics platform. This innovative Computer and Electronics Engineering Robot (CEENBoT), is a hands-on tool… more
Abstract:This project develops and evaluates the Enhanced Performance Training and Support System (EPTSS) to train and support individuals with autism spectrum disorder (ASD) in: behavioral training, modeling, self-management, and visual cues using available technology such as the iPod Touch/iPad. Phase I… more
Abstract:High fidelity simulations of complex systems still pose a challenge to the scientist trying to understand its physical characteristics. The challenge is in finding useful bits in terabytes of data that directly relate to the nature of time-varying, multivariate data. An intelligent data mining… more
Abstract:The monitoring of multiple UAV video sources is challenging, in part, due to the poor quality of the video received. Significant video degrading is caused by clouds, haze, and dust in the atmosphere; jitter and blurring from the UAV platform motion; and low video resolution due to sensor… more
Abstract:The potential for radio communications to be used in asymmetric operations against coalition forces has grown exponentially and has expanded well beyond the now-familiar IED detonators. Expeditionary forces, in particular, convoys on the move, need an effective counter surveillance capability to… more
Abstract:Current Army logistics systems contain massive amounts of data that need to be effectively extracted into actionable information. But, the databases themselves do not contain all that is needed to make it actionable. The Army needs an effective Enterprise Intelligence System to find data from many… more
Abstract:The ability to see and understand the data is critical to situational awareness. As data becomes more prevalent, the need to link causal data into actionable information becomes paramount. Analysts are faced with mountains of data, and finding that piece of relevant information is the proverbial… more
Abstract:To increase all-weather, visual search capabilities, modern submarine surface imaging systems have installed several different modality cameras in the periscope or photonic mast. The current system displays each sensor modality independently, where the operator must decide which modality is optimal… more
Abstract:OBJECTIVE: Current Software and System Engineering (SSE) methodologies for Human System Integration provide a process or sets of processes by which to develop a SSE-HSI scheme of how one integrates humans, operations, systems, and technical perspectives with requirements, analysis, and verification… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a system for automated classification of biological samples and discovery of biomarkers. The goal is a system to perform comprehensive pattern analysis of state-of-the-art biochemical separations generated by… more
Abstract:Innovations Plus seeks to provide the marine with competitive advantages and dramatically reduce hearing damage associated with firearms. Most small arm weapons do not include any form of sound suppression nor effective flash retardant. Thus, they subject the marine to harmful levels of noise and… more
Abstract:Innovations Plus, LLC is seeking to make the amount of ammunition on hand the firing rate limiter instead of the heat capacity of the barrel. The technical opportunity presented within this Phase I feasibility study is to increase the rate of fire for weapons by properly managing the heat developed… more
Abstract:In general, many biological and chemical agents affect the lungs directly or indirectly, even if the respiratory system is not the primary target organ of a military or terrorist attack. Both in the case of military and civilian attacks the lung can be one of the first organs affected by a chemical… more
Abstract:DESCRIPTION (provided by applicant): Diabetes mellitus (DM) in dogs is characterized by a rapid onset of bilateral cataracts that result in vision loss. Over 400,000 dogs annually develop cataracts that results in vision loss and currently the only medical
treatment for these dogs is cataract… more
Abstract:High fidelity, large scale simulations of complex systems pose a very difficult situation to the scientist trying to understand the physical domain and characteristics of their system. Often, it is impossible to manually search through the data that can come out of these simulations, which may range… more
Abstract:Providing commanders with accurate, on-the-spot, clear, concise, usable information wins battles and saves lives. With incoming information from many heterogeneous sources, the focus has been primarily on determining what information to present, and visual ways of communicating the information.… more
Abstract:There is a need for a next-generation integrative decision support system for Space Control operations. This next-generation system should provide high-level capabilities for managing case files containing evidence, expert opinions, and data relationships. The system should enhance operator… more
Abstract:In today's asymmetric warfare, there is a clear need to accelerate the flow of weapons from magazine to aircraft. This involves developing a semi-automated system that will significantly improve ordnance handling aboard air-capable ships. This system should prepare a Weapons Handling Plan using as… more
Abstract:Historically speaking, subjectivity was mostly considered as problematic and undesirable. Recently, the availability of the inherently subjective folksonomies has made it readily apparent that inherent subjectivity is highly desirable and that it can be accounted for and utilized by superimposing… more
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