Abstract:Project Goal/Intended Impact: To improve outcomes of in-treatment addicted patients by providing a virtual reality game as part of a regular health care visit with a health care provider. The game can be played with an off- the- shelf commercially available gaming system that can sense and be… more
Abstract:DESCRIPTION (provided by applicant): Investigational Safety and Toxicity Studies of Subcutaneous COG1410 for Alzheimer's Disease: A Therapeutic Based upon Apolipoprotein-E That is Not Targeted to Amyloid-Beta Background on Alzheimer's Disease: Alzheimer'sDisease (AD) is the leading… more
Abstract:DESCRIPTION (provided by applicant): Diabetic peripheral neuropathy (DPN) is one of the most common and devastating complications of diabetes mellitus, affecting more than 50% of diabetic patients, and is the leading cause of foot amputation. DPN, characterized by peripheral axonal degeneration and… more
Abstract:Corvid Technologies is pleased to offer this SBIR Phase I proposal. In the proposed effort, we will develop a fast-running, predictive methodology for the aerothermal demise of the debris generated during a Ballistic Missile Defense intercept event. This model will be informed by existing… more
Abstract:In a Phase I effort, Corvid Technologies will develop and test candidates for a series of advanced ballistic shields for crew served weapons stations intended to replace heavy, cumbersome shielding that does not meet required specifications. Current armor production efforts by Corvid will be… more
Abstract:On today"s battlefields, vehicles are at risk of encountering improvised explosive devices (IEDs). Fortunately, not all of these result in complete vehicle loss. Sending a vehicle back to the depot for overhaul when it could have stayed in operation, wastes precious resources. Conversely,… more
Abstract:As MDA continues implementation of the Phased Adaptive Approach (PAA), high fidelity and accurate characterization of post-intercept debris environments will become more and more critical to the successful operation of the larger Ballistic Missile Defense (BMD) system. The objective of this… more
Abstract:Corvid Technologies is pleased to offer this STTR Phase I proposal in collaboration with The Johns Hopkins University Applied Physics Laboratory and Spectral Sciences, Incorporated. The emphasis of the proposed effort is to develop a new methodology for predicting late-time EO/IR signatures from… more
Abstract:Corvid Technologies in collaboration with Dynetics, Inc ("Dynetics") is pleased to present the following proposal to the Missile Defense Agency (MDA) SBIR solicitation MDA12-028 entitled Improved Target Discrimination of Multiple Targets Using Bulk Filtering for Debris. This proposal will… more
Abstract:As MDA continues implementation of the Phased Adaptive Approach (PAA), robust operation of BMDS sensors within post-intercept debris environments will become more critical to successful operation of the larger BMDS. Due to a paucity of test data, development and performance testing of BMDS sensors… more
Abstract:The objective of the proposed Phase II program is to leverage existing first-principle physics-based codes and improve our ability to predict lethality outcomes for hypervelocity missile intercepts using our Velodyne code. In particular, we will address deficiencies in our high explosive (HE)… more
Abstract:Corvid Technologies is pleased to offer comprehensive computational analysis, experimental testing, and design of an advanced warhead. The objective is to design a warhead capable of overpressure defeat of point detonating fuses in rocket, artillery, and mortar (RAM) targets. A successful Phase I… more
Abstract:Corvid Technologies is excited to offer a unique solution for protecting tactical vehicles during high-speed external transport. The innovative design employs a fabric net structure rigged to the vehicle which significantly reduces the impeding air velocity on critical components. This approach… more
Abstract:DESCRIPTION (provided by applicant): Standard microfracture is a first-line, widely used and cost-effective surgical technique for repairing damaged articular cartilage, but, it is limited by decreased long-term efficacy and limited applicability in largerlesions. This leads to a burgeoning economic… more
Abstract:DESCRIPTION (provided by applicant): Controlling mechanical signal transduction to treat osteoarthritis Abstract The TRPV4 calcium (Ca++) permeable ion channel has been shown to be expressed and functional in chondrocytes, the cells responsible for the maintenance of cartilage in weight-bearing… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this study is to develop a tissue-engineered total joint replacement from an engineered biomaterial scaffold combined with adult bone marrow-derived mesenchymal stem cells (MSCs) for regeneration ofthe entire femoral surface of the hip joint.… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I effort is determine the feasibility of developing a unique antimicrobial catheter to reduce the instances of the most prevalent healthcare associated infection, Catheter-Associated Urinary TractInfection (CAUTI). This research and… more
Abstract:Sorghum is a major crop for food, feed and industrial processes in the US and on the global market. It is a particularly relevant crop under the current pressures of climate change and food security because it is adapted to cultivation under low water and nutrient conditions. However, compared to… more
Abstract:DESCRIPTION (provided by applicant): Medical drugs and devices are regulated by the U.S. Food and Drug Administration (FDA) based on data from multicenter clinical trials. In 2010, U.S. spending on clinical trials was approximately 25 billion. Over the past decade the efficiency of clinical trials… more
Abstract:DyMA-FM (Dynamic Multivariate Assessment for Fault Management) is a software architecture for real-time fault management. Designed to run in a distributed environment, DyMA-FM enables model-based reasoning and predictive modeling for FM applications. With the appropriate hardware, DyMA-FM can… more
Abstract:DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is common, expensive, and highly morbid. There are currently no therapies for AKI, and prevention and treatment represents a 6.3 billion market opportunity annually in the U.S. Moreover, patients are developing AKI more frequently and… more
Abstract:DESCRIPTION (provided by applicant): Myelosuppression continues to represent the major dose-limiting toxicity of cancer chemotherapy, resulting in considerable morbidity and mortality along with frequent reductions in chemotherapy dose intensity, which maycompromise disease control and survival.… more
Abstract:DESCRIPTION (provided by applicant): Patients with infective endocarditis (IE) have a poor prognosis with one third of the patients succumbing to the infection within the first year. Treatments for endocarditis involve antibiotic therapy and/or surgery that cost upwards of 100,000 per patient;… more
Abstract:DESCRIPTION (provided by applicant): Training mentored youth and their caregivers to work together successfully with their mentor and mentoring program is critically important for achieving a safe, high-quality, sustained mentoring relationship, and for obtaining positive youth outcomes. Training… more
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