Abstract:DESCRIPTION (provided by applicant): Standard microfracture is a first-line, widely used and cost-effective surgical technique for repairing damaged articular cartilage, but, it is limited by decreased long-term efficacy and limited applicability in largerlesions. This leads to a burgeoning economic… more
Abstract:DESCRIPTION (provided by applicant): Controlling mechanical signal transduction to treat osteoarthritis Abstract The TRPV4 calcium (Ca++) permeable ion channel has been shown to be expressed and functional in chondrocytes, the cells responsible for the maintenance of cartilage in weight-bearing… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this study is to develop a tissue-engineered total joint replacement from an engineered biomaterial scaffold combined with adult bone marrow-derived mesenchymal stem cells (MSCs) for regeneration ofthe entire femoral surface of the hip joint.… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I effort is determine the feasibility of developing a unique antimicrobial catheter to reduce the instances of the most prevalent healthcare associated infection, Catheter-Associated Urinary TractInfection (CAUTI). This research and… more
Abstract:Sorghum is a major crop for food, feed and industrial processes in the US and on the global market. It is a particularly relevant crop under the current pressures of climate change and food security because it is adapted to cultivation under low water and nutrient conditions. However, compared to… more
Abstract:DESCRIPTION (provided by applicant): Medical drugs and devices are regulated by the U.S. Food and Drug Administration (FDA) based on data from multicenter clinical trials. In 2010, U.S. spending on clinical trials was approximately 25 billion. Over the past decade the efficiency of clinical trials… more
Abstract:DyMA-FM (Dynamic Multivariate Assessment for Fault Management) is a software architecture for real-time fault management. Designed to run in a distributed environment, DyMA-FM enables model-based reasoning and predictive modeling for FM applications. With the appropriate hardware, DyMA-FM can… more
Abstract:DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is common, expensive, and highly morbid. There are currently no therapies for AKI, and prevention and treatment represents a 6.3 billion market opportunity annually in the U.S. Moreover, patients are developing AKI more frequently and… more
Abstract:DESCRIPTION (provided by applicant): Myelosuppression continues to represent the major dose-limiting toxicity of cancer chemotherapy, resulting in considerable morbidity and mortality along with frequent reductions in chemotherapy dose intensity, which maycompromise disease control and survival.… more
Abstract:DESCRIPTION (provided by applicant): Patients with infective endocarditis (IE) have a poor prognosis with one third of the patients succumbing to the infection within the first year. Treatments for endocarditis involve antibiotic therapy and/or surgery that cost upwards of 100,000 per patient;… more
Abstract:DESCRIPTION (provided by applicant): Training mentored youth and their caregivers to work together successfully with their mentor and mentoring program is critically important for achieving a safe, high-quality, sustained mentoring relationship, and for obtaining positive youth outcomes. Training… more
Abstract:Adolescents with Fetal Alcohol Spectrum Disorder (FASD) are at risk for substance use and abuse. Given the dearth of Interventions designed specifically for adolescents with FASD, there exists a need for evidence-based preventive intervention programs forthis population. Thus, the goal of the… more
Abstract:PROJECT SUMARY/ABSTRACT This proposed project is in response to the need for more extensive toxicological evaluation of environmental chemicals and for predictive models to assess associated risks of chemical exposure to humans. There is also need for innovative methods for evaluating the effects of… more
Abstract:Although several critical energy saving technologies under development today require Gallium Nitride (GaN) based semiconductor devices, a source of high quality and inexpensive GaN wafers does not yet exist. This lack of GaN wafers adds complexity to GaN device production and makes development of… more
Abstract:Gallium Nitrides (GaN) device market size is second only to silicon and is projected to be $50-100 billion in size as markets mature for GaN power devices, solid state lighting, and hundreds of other new applications. Even with this remarkable forecast, GaN epitaxy is still produced primarily on… more
Abstract:Gallium Nitride (GaN) crystals have recently garnered attention as a candidate for use as a Quasi-Phase Matching (QPM) material for frequency conversion applications such as second harmonic generation (SHG) and optical parametric oscillation (OPO), due to its wide bandgap (3.4eV), high thermal… more
Abstract:In Phase I, a novel porous electrode was designed to demonstrate a rapid, simple assay for the detection of domoic acid in marine samples. During Phase II, methods to manufacture porous electrodes will be improved to enable high volume production of low-cost biosensors that can be connected to a… more
Abstract:Through this effort, NanoTechLabs Inc. will improve the efficiency and lower the mass of the cryogenic heat exchanger used in American Superconductor's High Temperature Superconducting Degaussing system. NanoTechLabs will achieve these goals by producing a Carbon Nanotube metal matrix composite… more
Abstract:ABSTRACT: Through the Phase II program, NTL will finalize the materials development and demonstrate the ability of a TIM material based on carbon nanotube vertical arrays to meet general requirements for space applications. In addition we will define and initiate tests required for a specific Air… more
Abstract:DESCRIPTION (provided by applicant): Mucus transport is the fundamental defense of the airways against inhaled particulates/infectious agents. Abnormalities in the mucus transport system characterize a complex of muco-obstructive airway diseases, such as cystic fibrosis (CF) and chronic bronchitis… more
Abstract:DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is an autosomal lethal disease characterized that affects ~30,000 individuals in the US. CF lung disease, the major cause of mortality in CF, is caused by dehydration of airway secretions that leads to mucous adhesion, infection and airways… more
Abstract:Signal Innovations Group proposes a hierarchical Bayesian approach for non-linear dimensionality reduction that addresses three key challenges: learning a reversible mapping from a high-dimensional observed space to a low-dimensional embedded space, learning the dimension of the embedded space, and… more
Abstract:The detection and tracking of dismounts and the identification of threatening dismounts are critical challenges for ensuring mission success and troop safety when conducting tactical vehicle operations in hostile environments. Vehicle operators must focus on multiple tasks simultaneously: … more
Abstract:ABSTRACT: Current automatic target recognition (ATR) training processes require expensive data collections or extensive, high fidelity target modeling and validation whose costs and lead times will limit the ongoing sustainability of ATR target databases. Radar based systems for combat… more
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