Abstract:DESCRIPTION (provided by applicant): Diabetes costs the United States an estimated 174 billion annually. About two-thirds of costs arise from direct medical expenditures, and the remainder accrues from disability, work loss, and premature mortality. Assoc
iated cardiovascular comorbidities result… more
Abstract:DESCRIPTION (provided by applicant): Identifying the regulatory regions of the genome is critical for understanding the regulatory networks underlying human development and disease. Chromatin immunoprecipitation (ChIP) coupled with microarray (ChIP-chip)
or sequencing (ChIP- seq) is a widely used… more
Abstract:Many of the antibodies produced for cancer research are poorly characterized, exhibit suboptimal affinity or selectivity, and are time-consuming and expensive to produce. Alternative affinity capture reagents are therefore needed as reproducible, highly characterized, rapid, and cost-effective… more
Abstract:DESCRIPTION (provided by applicant): The Patch Clamp technique has evolved in recent years from an esoteric method of basic electrophysiological research into properties of cell membranes, into a practical technique for mass screening compounds for potenti
ally therapeutic pharmaceutical properties.… more
Abstract:Crosslink proposes to develop a two-layer protective coating system for the protection of aircraft canopies and transparencies that meets the Air Force requirements for electrical and optical performance, durability, adhesion, and light transmission. The Crosslink system will utilize an organic… more
Abstract:The objective of this proposal is to demonstrate the feasibility of producing a multi-node communication network with low latency for use in the hardware-in-the-loop (HWIL) test environment. In the HWIL environment, multi-node connectivity latencies ideally would be at or near zero to prevent the… more
Abstract:How much energy can be saved by opening a window instead of running an air conditioner? How does this affect the air quality of a home? With rising energy costs and as concern for the environment grows more widespread, the need to conserve energy resources is becoming more apparent. Although many… more
Abstract:The importance of fast, reliable detection of pathogens in drinking water in the United States and worldwide, is increasing rapidly due to rising populations and increasing environmental degradation, as well as the threat of terrorism. Although the technology readiness level of rapid detection… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a new photoresist material with dual tones for micro-photolithography. Traditional photoresist material responds to radiations in either positive or negative tone respectively. In this project, a dual-tone photoresist… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. Using a protein informatics approach, we
have successfully engineered a human… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. This enzyme strongly inhibits platelet a
ctivation and aggregation with modest… more
Abstract:The proposed JP-8 powered cooling technology was co-invented by ThermAvant Technologies, LLC and the University of Columbia-Missouri (MU). The technology is based on the ejector cooling cycle and has the following unique features: thermodynamically and fluid dynamically optimal working fluids for… more
Abstract:A cooling system that converts waste heat from power supply units into useful space cooling is sought by the U.S. Army to reduce the electrical loads and fuel consumption in mobile military platforms. Unfortunately, conventional heat actuated systems are too large and inefficient. ThermAvant… more
Abstract:X-ray computed tomography (CT) is used to evaluate the integrity and aging of solid rocket motors (SRM) used in missile defense. There is a need for better vizualization of bondlines of materials, and the detection of their flaws, in the dome region. This problem is due to partial volume effects… more
Abstract:DESCRIPTION (provided by applicant): Every year in the United States, gt1.25 million people suffer from burns, 6.5 million have chronic skin ulcers caused by pressure, venous stasis or diabetes mellitus and 0.25 million have keloids sufficiently severe to
require surgery. Burn treatment costs 1.8… more
Abstract:Successful completion of the proposed Phase I work outlined and follow-on Phase II work will provide a system to rank existing materials and coatings for severe wear applications. In addition, the ranking system can be utilized to identify desirable properties in new materials and/or coatings that… more
Abstract:This SBIR Phase I project will develop novel nematicides using proprietary chemical design and screening methods. The project will first design, prioritize, and synthesize a set of entirely novel molecules. The project will then evaluate compounds for activity in multiple biological assays with… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a rapid and accurate immunodiagnostic test for detection of soil- transmitted helminths (STHs) that can be used without laboratory infrastructure. Human STH infect
ions from whipworm (Trichuris), roundworm… more
Abstract:An estimated one-third of worldwide crop production is lost to pathogens including fungi. Despite advances in chemical control, the onset of resistance limits the utility of current fungicides. In addition, most pesticide research projects are terminated because of unattractive attributes of the… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop a highly simplified and improved method of detecting RNA for use in clinical tests and for scientific research by enabling the RT-PCR amplification of nucleic acids directly in whole blood, serum,
plasma, and cell lysates. We propose a dual… more
Abstract:The development of a procedural and computational framework for improved prediction of damage accumulation caused by cyclic loading in metallic airframe components is proposed. This framework will be based on the idea that models formulated for the prediction of crack nucleation, i.e., for the… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project proposes to further investigate use of a body-mounted, inertial sensor motion analysis system as a field-ready, objective evaluation technique to detect and evaluate locomotion disturbances in the horse. Research objectives involve… more
Abstract:DESCRIPTION (provided by applicant): Mitochondrial disease caused by point mutations in mitochondrial DNA (mtDNA) can be a formidable diagnostic challenge. Because clinical presentation is variable, multisystemic, and mimics many other neurological disorders, ruling out a mtDNA etiology is… more
Abstract:Rural college students have a significant need for improved quality and efficiency mental health services for Major Depressive Disorder. Iconic Health proposes to address this need by building upon the HomePsych communication platform, integrating a process whereby mobile symptom reporting is… more
Abstract:For this Phase I program, MO-SCI Corporation and Missouri University of Science and Technology (Missouri S&T) will develop reactive fusion and reactive plasma welding techniques that are capable of joining ultra-high temperature ceramic (UHTC) composites. Past work at Missouri S&T demonstrated the… more
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