Abstract:ABSTRACT: This proposal seeks to develop a novel tool wear monitoring technology using a neural network-based observer. In this methodology simple models of the wear process and another related machining process, such as force, are developed. The model development does not require lengthy analysis… more
Abstract:Glycosylation changes are a universal feature of malignant transformation and tumor progression. Changes in expression levels of certain glycoproteins and altered glycosylation patterns have been detected in most of the major human cancer types and at different stages of tumor progression. The… more
Abstract:According to the American Cancer Society, 192,370 women in the United States will be diagnosed with invasive breast cancer in 2010, leading to 40,170 deaths. Most women with breast cancer undergo surgery to remove the cancerous tissue and then receive additional treatment. Adjuvant therapy does not… more
Abstract:A Fast Impulse Solid Fuel Miniature Thruster system will be developed for a specific application beneficial to the US Army. The selection of right nanoenergetic material will be done from various fuel-oxidizer systems to obtain thrust and specific impulse as required by the application. Fine-tuning… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a Multi-Axis Repair System (MARS), which is an automated precision alignment and repair planner and driver. MARS will make repair processes much more cost-effective and robust. Insufficient automation in current repair… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project evaluates a completely new low cost/high efficiency generator system called Q-Gen? Portable for use in portable recharging devices. The Q-Gen? Portable will recharge handheld electronic devices (laptops, cell phones etc) without… more
Abstract:QM Power will build and empirically test Space and Cryogenic qualified preproduction Parallel Magnetic Circuit [PMC] 1-5 HP motor/actuators with electronic controllers. These preproduction prototypes will demonstrate lower operating power requirements for cryogenic motor/actuator components used in… more
Abstract:Refrigeration and air conditioning in buildings, industry, and transportation account for approximately 10 quads of U.S. primary energy consumption. Motors power the equipment and control the environment in advanced cooling applications and thus their energy consumption represents a significant part… more
Abstract:Today, conventional hydropower generation accounts for 75% of the United States renewable energy generation (over 270,000 GWH) despite utilizing less than 20% of the usable hydropower available for development. Recent studies indicate that advances in lower cost higher performing generator… more
Abstract:Medical robotic applications require numerous actuation devices that must be both lightweight and efficient. In the case of mobile medical robotics, Space, Weight, and Power efficiency (SWaP) are the key performance attributes for most designs. The objective of this proposal is to design and… more
Abstract:DESCRIPTION (provided by applicant): A rapid method for concentrating bacteria from real apple juice and spinach wash water into a small volume, which is easily analyzed by advanced detectors, will enable rapid detection of small numbers of bacteria and provide for improved consumer safety and… more
Abstract:Detection of bioaerosols is a cornerstone in the protection of our nation from bioterrorist events. Rapid bioaerosol detection systems
have advanced dramatically in recent years, but the lack of integratable automated sample preparation for these systems remains a
major deficiency. Three significant… more
Abstract:Shock-wave/boundary-layer interactions (SWBLI) pose challenges to aeronautical engineers because they create regions of adverse pressure gradients as a result of the discontinuous change in conditions across the shock. This shock-induced pressure gradient is a common factor for both flow separation… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this SBIR project is to develop a new dual-modality inflammation imaging technology to early detect Uveitis, an ocular inflammation-related disorder. This technology, based on nanocomposites (NCs) that function as dual-modality fluorescent and… more
Abstract:DESCRIPTION (provided by applicant): Nitric oxide (NO) has been shown to have powerful, broad-spectrum antimicrobial activity as well as benefits in wound healing when properly administered [1-3]. The combination of these two attributes makes development of a non-systemic NO delivery approach… more
Abstract:DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most prevalent clinical arrhythmia in clinical practice and a major contributor to morbidity and mortality. A recent study estimated that the number of Americans afflicted by AF will increase from the current range of 2.2 to 5.6… more
Abstract:DESCRIPTION (provided by applicant): Cells secrete hormones and neurotransmitter via exocytosis. Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance. The overall goal of this SBIRproject is to use microfabrication… more
Abstract:The androgen receptor (AR) remains a key therapeutic target for prostate cancer (PCa), even in castration resistant PCa (CRPC). Current therapies target AR by blocking androgen synthesis or competitive antagonism. ARTA Bioscience is developing an early lead, ABS-001, a non-competitive AR inhibitor… more
Abstract:Invention House LLC proposes to lower the initial cost of solar energy by minimizing the material used in the reflector of a concentrating trough. Placing the support structure on the front (sun) side and using a thin reflecting membrane will reduce material usage and cost by approximately 66%. The… more
Abstract:HyBeacons Probe Assays for the Detection of Ticks and Tick-Borne Pathogens Patrick Williams, Ph.D., Evogen Inc., 8301 State Line Road, Kansas City, MO 64114 The proposed development will evaluate the use of Evogen"s HyBeacons probes for rapid, multiplexed vector and pathogen detection using… more
Abstract:Akermin proposes, in collaboration with the University of New Mexico, to demonstrate the viability of electronic connections between biomolecules and engineered surfaces in order to harvest power and energy through biologic systems. This work is in part based on Akermin's proprietary enzyme… more
Abstract:This SBIR Phase I project will develop an enzymatic bio-fuel cell using a unique enzyme stabilization technology. The technology overcomes the stability and lifetime issues faced by conventional bio-fuel cells where rare metals serve as the catalyst. Development of the bioanode for the fuel cell… more
Abstract:DESCRIPTION (provided by applicant): Secondary metabolites will be extracted from a specific plant material to identify and isolate immune active components. These components are proposed to enhance the innate and adaptive immune systems by modulating cert
ain cytokine levels in white blood cells… more
Abstract:DESCRIPTION (provided by applicant): Diabetes costs the United States an estimated 174 billion annually. About two-thirds of costs arise from direct medical expenditures, and the remainder accrues from disability, work loss, and premature mortality. Assoc
iated cardiovascular comorbidities result… more
Abstract:DESCRIPTION (provided by applicant): Identifying the regulatory regions of the genome is critical for understanding the regulatory networks underlying human development and disease. Chromatin immunoprecipitation (ChIP) coupled with microarray (ChIP-chip)
or sequencing (ChIP- seq) is a widely used… more
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