Abstract:The Phase II technical objective of this project is to implement the technology conceived in Phase I into hardware prototypes that can be tested in an actual HWIL test lab environment. The developments and experience acquired in Phase I will be used to design and assemble a fully functional central… more
Abstract:DESCRIPTION (provided by applicant): Vasculox, Inc. is developing a humanized anti-CD47 mAb for reducing ischemia-reperfusion injury (IRI) in organ transplantation. In spite of improvements in surgical technique, organ preservation and immunosuppression, IRI remains a serious limitation and is… more
Abstract:DESCRIPTION (provided by applicant): Acute myocardial infarction is the leading cause of death in most industrialized nations. The estimated annual incidence in the US is 865,000 events, with ST-segment elevation myocardial infarction (STEMI, severe AMI)comprising an estimated 500,000 events per… more
Abstract:DESCRIPTION (provided by applicant): The saphenous vein is the most commonly used graft for coronary artery bypass and peripheral bypass surgery, but has poor patency. 15-20% grafts fail in the first month and approximately 25% in the first year. Early vein graft occlusion is typically due to… more
Abstract:This Small Business Innovation Research Phase I project will demonstrate a highly efficient supersonic ejector vapor compression technology that converts low-to-medium grade thermal energy (200-400F) into useful refrigeration (20F-50F) at high condenser temperatures (100-120F). The proposed… more
Abstract:ABSTRACT: Miniature flat plate oscillating heat pipe (FP-OHP) heat spreaders using ThermAvant's patent-pending ThermalCircuit architecture and low CTE materials will be demonstrated in order to transfer 100-300W/cm2 from chip-sized heaters (1cm2 to 3cm2) to a heat sink area that rejects heat… more
Abstract:The objective of Phase I is the preliminary design, prototype and testing of a 3D spectral imaging system for the characterization and evaluation of viability of engineered tissue for treating war injuries. The purpose is in ensuring tissue viability, maturity, vascularity to know if a construct is… more
Abstract:ABSTRACT: High Energy X-ray computed tomography (CT) is used to inspect and evaluate the integrity of solid rocket motors (SRM"s). The driving purpose of this proposal is to improve the detection of defects in special cases where the defects are obscured due to limitations of the CT images. … more
Abstract:DESCRIPTION (provided by applicant): This research will have a significant and potentially broad impact on reducing blindness and vision loss of Americans. Many predominant eye conditions, associated with blindness and vision loss, disturb and compromise the photoreceptors. This research will enable… more
Abstract:ABSTRACT: The proposal outlines work and time tables associated with finalizing the development of wear model concepts developed in Phase I work to predict the wear of two materials sliding with respect to each other while being subjected to high velocities and/or high pressures. In parallel with… more
Abstract:DESCRIPTION (provided by applicant): Currently, more than 60 % of end-stage renal diseases patients who require chronic hemodialysis are accessed through a native arteriovenous fistula (AVF) or synthetic graft (AVG). Unfortunately, primary failure rates were as high as 60 % at 6 months after AVF… more
Abstract:DESCRIPTION (provided by applicant): Recently, Drs. Randall Bateman and David Holtzman at the Washington University School of Medicine developed a novel stable isotope labeling kinetics (SILK) methodology for measuring the metabolism of amyloid beta (AB) in the human central nervous system (CNS).… more
Abstract:ABSTRACT: MO-SCI Corporation and Missouri University of Science and Technology have developed and evaluated fusion welding technology applicable to ultra-high temperature ceramic (UHTC) composite joining during a Phase I ceramic joining program. This Phase II program will improve arc and reactive… more
Abstract:DESCRIPTION (provided by applicant): Improved long-term biocompatibility of coronary stents by plasma coating process Abstract Drug-eluting stents (DES) have been widely used to treat patients of cardiac disease due to their better ability to control restenosis than bare metal stents (BMS). However,… more
Abstract:ABSTRACT: The objective of the Phase II effort is to extend the mathematical model investigated in the Phase I to include wind speed as well as temperature modeling, continue its development for a University of Notre Dame Wind Tunnel Facility, and demonstrate utility by adopting the model to a… more
Abstract:The objective of the proposed research and development work is to create new types of compact, autonomous multi-pulse single-shot explosive-driven power supplies that are capable of producing a series of high voltage and/or high current pulses. These generators can be used in new kinds of warheads… more
Abstract:We propose to extend existing free and open source software to construct a framework solution which implements a multi stage process to support the SBIR requirements. The baseline approach includes an encoding stage followed by a compression stage with optional encryption and transmission stages.… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project evaluates a low cost, high efficiency portable power system called the QM Power ?PoD?? (Power on Demand). The PoD will power handheld consumer electronic devices (cell phones, tablets, laptops etc) utilizing a rechargeable battery and… more
Abstract:In this Phase II SBIR project, QM Power will build and integrate the high performance alternator researched, analyzed and developed during the Phase I SBIR effort with an internal combustion engine using load following power electronics and demonstrate through empirical testing in a simulated… more
Abstract:The objective of this proposed SBIR Phase I effort is to design, analyze, and demonstrate a high performance 3kW alternator that has no rare earth content and simultaneously is smaller, lighter, quieter and more efficient than alternators based on induction machines currently in the Armys inventory.… more
Abstract:Detection of bioaerosols is a cornerstone in the protection of our nation from bioterrorist and pandemic events. Rapid bioaerosol detection systems
have advanced dramatically in recent years, but the lack of integratable automated sample preparation for these systems remains a major deficiency… more
Abstract:The one CFD modeling area that has remained the most challenging, yet most critical to the success of integrated propulsion system simulations, is turbulence modeling. There is a need to develop mid-level CFD models for the interaction of turbulence and chemical reactions that give superior results… more
Abstract:DESCRIPTION (provided by applicant): Sudden cardiac death is a major cause of death around the world, with approximately 400,000 sudden deaths per year in the United States, more than are attributed to lung cancer, breast cancer, or AIDS. It is often caused by ventricular fibrillation (VF) and… more
Abstract:Tick borne diseases pose a significant threat to deployed military forces and local civilian populations. Different species of ticks vector different pathogens; therefore it is important to be able to differentiate numerous species of ticks at any stage of their life cycle. Evogen has optimized the… more
Abstract:The interconnected consequences of the national energy strategy compel us to design energy systems to operate at higher temperatures to achieve greater efficiency and reduced greenhouse gas emissions. The success of various promising clean coal technologies will rely in part on sensors that can… more
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