Abstract:There is presently a great deal of interest in developing efficient, nontoxic, cell-specific gene tSpecifically, there has been a focused interest in the development of nonviral vectors which have setheir viral counterparts in that they cannot reconvert, they can be designed to carry a variety of… more
Abstract:The cavity perturbation method is currently widely used for the characterization of the complex dielectric constant of material samples. This method provides a simple analytical solution by relating the real and imaginary parts of the dielectric constant of the sample to the changes in the measured… more
Abstract:The objective of this program is to develop a thin/thick film materials deposition process technology which will reliably provide high quality materials for constructing Peltier thermo-elements with a high figure of merit over the temperature range of 250-350 Deg K. The study will focus on the… more
Abstract:The objective of this program is to design a high energy density hydrogen stroage system, utilizing ECD's extensive experience in metal hydride technology. The system will be based on ECD's ability to develop novel metal hydrides that have the potential to achieve gravimetric energy density of 2… more
Abstract:We will develop and validate a fiber optic sensor for measuring lead in blood which can measure 1-100 micro g/dL concentrations of lead in blood using an innovative Lead Ion Selective Fiber Optode (LISFO) technology. The sensor will require a blood volume less than 200 micro L and will be capable of… more
Abstract:Although many fluorophores exist which are suitable for labeling biomolecules, most of them have absorbance and fluorescence wavelenghts which overlap with naturally occurring biological fluorescence. This complicates their use with optical bio- sensors. A very limited number of commercially… more
Abstract:We will develop an automated instrument for the detection and quantification of Giardia and Cryptoswater sources. The long-term objective is the development and commercialization of a portable, ruggeinstrument which rapidly processes filter concentrated samples without the use of trained… more
Abstract:In spite of the rapid advances in the speed and density of electronic components, a compact hardware package providing a complete real-time solution to vision problems remains beyond the capabilities of currently available technology. This project proposes to develop a smart CCD camera using a… more
Abstract:This proposed project combines ideas from neuro-biological modeling of the cochlea, engineering designs of optimal filters, the theoretical formulation using the calculus of variations, and optimal filtering and control. Several competing formulations will be developed. A potential breakthrough… more
Abstract:The goal of the proposed research is to recycle PET and eventually other plastic wastes, through depolymerization while avoiding costly purification and color-removal steps, into low-cost and highly durable rapid-setting rehabilitation materials. Successful implementation of the proposed technology… more
Abstract:MICROORGANISMS ARE PRIMARILY RESPONSIBLE FOR THE DEGRADATION OF TOXIC CHEMICALS THAT ENTER THE ENVIRONMENT. SUCCESSFUL ISOLATION AND EXPLOITATION OF THESE MICROBES FOR BIOREMEDIATION REQUIRES IDENTIFYING THE PHYSICO-CHEMICAL CONDITIONS UNDER WHICH DETOXICATION ACTIVITY IS MAXIMIZED. THIS WORK IS… more
Abstract:Our objective is to prove feasibility of ultrasensitive chemiluminescent assays for the 21 aminoacid polypeptide from HIV gp 120 by Western blotting and cystic fibrosis transmembrane regulator geneby Southern blotting. We have developed a proprietary enzyme-label chemiluminescent detection… more
Abstract:We will develop a new generation confocal microscope uniquely capable of ultraviolet (UV) as well as visible illumination and video-rate imaging. In Phase I, experiments will be conducted to determine the components and dimensions needed to correct for the longitudinal and lateral chromatic errors… more
Abstract:Optical microscopy is an important tool for investigations of biological structure and function inFar-field optics are restricted in resolution, however, to a physically defined limit of 200 nm. Invsubcellular organization and structure below this limit have required electron microscopy, which… more
Abstract:This Phase I proposal is aimed toward research and development of novel low cost commercially feasible environmentally-friendly biodegradable polymeric thermosetting materials based on epoxidized triglyceride oils. The inexpensive thermosets based on epoxidized soybean oil ($0.50/lb) and sucrose… more
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