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State:Maryland
Company: BIOQUAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: DIZYGOTIC MOSAIC ANIMALS (CHIMERAS, ALLOPHENICS) ARE EXPERIMENTALLY PRODUCED BY AMALGAMATING PREIMPLANTATION EMBRYONIC TISSUES. THE COMBINED EMBRYOS ARE REMOVED TO THE REPRODUCTIVE TRACT OF PSEUDOPREGNANT SURROGATE MOTHERS. ADULT TISSUES OF THE OFFSPRING ARE MOSAIC OF THE PROGENY OF CELLS DERIVED… more
Company: Biotech Research Laboratory Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: BIOTECH HAS DEVELOPED A SYSTEM FOR LABELING DNA FRAGMENTS WITH HAPTEN-MODIFIED ""TAILS'' WHICH CAN BE DETECTED BY IMMUNOLOGICAL METHODS USING ENZYME-CONJUGATED ANTIBODIES. THE DETECTION SENSITIVITY OF THIS SYSTEM IS 274 PICOGRAM, WHICH IS SUFFICIENT TO DETECT SINGLE COPY GENES IN HUMAN DNA. THE AIM… more
Company: Brimrose Corporation of America Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: SEVERAL INVESTIGATIONS HAVE BEEN CONDUCTED INTO THE EXISTANCE AND PHENOMENALOGICAL ORIGIN OF CAVITIES IN RDX. THESE STUDIES CLEARLY HIGHLIGHT THE RELEVANCE OF GROWTH VARIABLES/PARAMETERS IN THE ULTIMATE QUALITY OF RDX CRYSTALS. SOME OF THE MOST SIGNIFICANT FACTORS AFFECTING THE SIZE, DENSITY AND… more
Company: Brimrose Corporation of America Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: NUMEROUS STUDIES HAVE BEEN CONDUCTED INTO THE MICROSTRUCTURAL ORIGIN OF THE INSTABILITY AND UNPREDICTABILITY OF VARIOUS ENERGETIC MATERIALS. SOME OF THESE MATERIALS ARE RDX/HMX, AMMONIUM PERCHLORATE, ALUMINUM, ETC. MANY TECHNIQUES BOTH DESTRUCTIVE AND NONDESTRUCTIVE HAVE SO FAR BEEN UTILIZED IN AN… more
Company: Brimrose Corporation of America Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: Brimrose Corporation of America Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: Business & Technological Syste Agency/Program/Year/Phase: NSF / SBIR / 1986 / 2
Abstract: THE CONCEPT OF USING RECURSIVE ESTIMATION METHODS FOR GEOMAGNETIC FIELD MODELING WAS DEMONSTRATED (BY BTS) IN A PREVIOUS LIMITED INVESTIGATION. THE RESEARCH PROPOSED HERE ATTEMPTS TO SOLVE SOME OF THE PROBLEMS ENCOUNTERED IN THAT STUDY SO THAT THE FULL POTENTIAL OF THE RECURSIVE ESTIMATION APPROACH… more
Company: Business & Technological Syste Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: Business & Technological Syste Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: C-MOTION, INC. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: EXPERIENCE WITH THE CLONING AND EXPRESSION OF CLONED GENES IN SACCHAROMYCES CEREVISIAE SUGGESTS THAT THE RECOVERED YIELD OF CORRECTLY FOLDED PROTEIN PRODUCT IS GREATLY IMPROVED BY THE USE OF A YEAST-SECRETION PROCESS. THIS IS ESPECIALLY TRUE FOR PROTEINS THAT ARE NORMALLY SECRETED FROMTHEIR NATURAL… more
Company: Comsis Corp. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THIS PROPOSAL IS FOR THE FIRST PHASE OF A TWO-PHASE PROJECT TO DEVELOP A COMPREHENSIVE MODEL OF THE AGE-RELATED BARRIERSAND DIFFICULTIES THAT DISCOURAGE DRIVING OR REDUCE SAFETY FOR OLDER MOTORISTS. THIS UNIQUE PROGRAM INCORPORATES PERCEPTUAL, COGNITIVE, AND MOTOR CAPABILITIES; SOCIAL AND… more
Company: Cyto Fluidics Inc. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: THIS PROPOSAL INVOLVES THE DESIGN, DEVELOPMENT, AND EVALUATION OF A MULTI-CHAMBER, LABORATORY-SCALE, SEMI-CONTINUOUS CELL CULTURE SYSTEM FOR MORE EFFICIENT, COST EFFECTIVE PRODUCTION OF MONOCLONAL ANTIBODIES (MAB). CONCEPTS WOULD BE INVESTIGATED WHICH WOULD ALLOW MODULAR CELL CHAMBERS TO BE… more
Company: Dedicated Response Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE PURPOSE OF THIS RESEARCH IS TO USE THE RESULTS OF PRIOR RESEARCH AND DEVELOPMENT BY DEDICATED RESPONSE ON GENERALIZED DATA MANAGEMENT SYSTEMS, ALONG WITH THE SYSTEMS ANALYSIS AND DATA ENTRY SOFTWARE AVAILABLE FOR MINI - AND - MICROCOMPUTERS. THE PROJECT WILL CREATE A DATA PROCESSING TOOL KIT.… more
Company: Digene Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: NUCLEIC ACID HYBRIDIZATION (NAH), AN EXTREMELY IMPORTANT MOLECULAR BIOLOGY RESEARCH TOOL, HAS THE POTENTIAL TO BE A MAJOR DIAGNOSTIC PROCEDURE. HOWEVER, THE CURRENT TECHNIQUE REQUIRES THE USE OF EXPENSIVE, HAZARDOUS, AND TIME-CONSUMINGMETHODS BASED ON RADIOACTIVE MATERIALS. FURTHERMORE, NAH TESTS… more
Company: Digene Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: NEW DNA DIAGNOSTIC TESTS WILL PERMIT THE RAPID, ACCURATE, SENSITIVE, AND INEXPENSIVE DIAGNOSIS OF A WIDE VARIETY OF DISEASES WITHOUT GROWTH, EXPRESSION OF SPECIFIC CELL FUNC- TION, OR PRODUCTION OF SPECIFIC PROTEINS BY THE AGENT. FUR-THERMORE, POSITIVE IDENTIFICATION IS INDEPENDENT OF ANTIGEN-IC… more
A PASSIVE VARIABLE THERMAL RESISTANCE DEVICE IS PROPOSED WHICH UTILIZES A FLEXIBLE HEAT PIPE SWITCH.
Company: DYNATHERM CORP. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: A PASSIVE VARIABLE THERMAL RESISTANCE DEVICE IS PROPOSED WHICH UTILIZES A FLEXIBLE HEAT PIPE SWITCH. THE PRINCIPLE ELEMENT OF THE SWITCH IS A HEAT PIPE CHAMBER WITH A FLEXIBLEENVELOPE. THE SWITCH IS PERMANENTLY ATTACHED TO THE HEAT SOURCE. INCREASING SOURCE TEMPERATURE ELEVATES THE HEAT… more
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