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State:Maryland
Company: MARTEK BIOSCIENCE CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
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Company: MARTEK BIOSCIENCE CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: Mentor Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1988 / 1
Abstract: VLSI (VERY LARGE SCALE INTEGRATION) TECHNOLOGY HAS BEEN DEVELOPED TO THE POINT WHERE HIGH SPEED FLOATING POINT PROCESSORS MAY BE CONCATENATED TO FORM COMPACT SUPERCOMPUTERS WITH FAR GREATER THROUGHPUT THAN UNIPROCESSOR MACHINES. MTI PROPOSES TO DESIGN AND DEVELOP A MULTIPROCESSOR COMPUTER… more
Company: Mentor Technologies, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: MULTI-ELECTRODE TECHNOLOGY HAS BEEN DEVELOPED TO THE POINT WHERE SIGNIFICANT AMOUNTS OF MULTI-UNIT DATA FROM SPATIALLY OVERLAPPING CELL POPULATIONS ARE BEING RECORDED. A SUITABLE MULTI-CHANNEL SIGNAL PROCESSOR IS NEEDED. MTI PROPOSES A COMPUTATIONALLY INTENSIVE ARRAY PROCESSING ARCHITECTURE WHICH IS… more
Company: Microbiological Associates Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: MICROBIOLOGICALLY-DEFINED MICE AND RATS ARE REQUIRED FOR SOPHISTICATED BIOMEDICAL RESEARCH. SEROLOGICAL PROCEDURES ARE THE MOST FEASIBLE AND ECONOMICAL MEANS TO MONITOR THE HEALTH STATUS OF LABORATORY ANIMALS. A MAJOR PROBLEM ARISESWHEN THE RESULTS OF VARIOUS TEST-KITS AND IN-HOUSE TESTING… more
Company: Microbiological Associates Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: TWO DISTINCT, VIRALLY INDUCED INFECTIONS IN NONHUMAN PRIMATES THAT CAUSE SUBSTANTIAL MORBIDITY AND MORTALITY AND HAVE CLINICAL RELEVANCE TO THE HUMAN AIDS VIRUS HAVE BEEN IDENTIFIED RECENTLY. THE FIRST, DESIGNATED SAIDS, IS CAUSED BY A VARIETY OF CLOSELY RELATED TYPE D VIRUSES. THE SECOND IS INDUCED… more
Company: Microbiological Associates Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE PURPOSE OF THIS PROJECT IS TO IMPROVE THE HAMSTER EMBRYO CELL CLONAL TRANSFORMATION ASSAY TO INCREASE THE MORPHOLOGICAL TRANSFORMATION RATE AND INTRODUCE AN ADDITIONAL ENDPOINT, COLONY FORMATION IN SOFT AGAROSE. THE METHODOLOGY DESCRIBED INTRODUCES A SELECTIVE STEP WHICH ENTAILS SUSPENSION OF… more
Company: Molecular Diagnostic Systems Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: EPSTEIN-BARR VIRUS (EBV) CAUSES MONONUCLEOSIS, IS STRONGLY IMPLICATED IN BURKITT'S LYMPHOMA AND NASOPHARYNGEAL CARCINOMA, AND MAY BE ASSOCIATED WITH RHEUMATOID ARTHRITIS. INDIVIDUALS WITH THESE DISEASES PRODUCE ANTIBODIES TO VIRAL EARLY ANTIGENS, CAPSID ANTIGENS, AND NUCLEAR ANTIGENS. THE IMMUNE… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE SEARCH FOR A PHARMACOLOGICAL AGENT THAT WILL FACILITATE WEIGHT REDUCTION REMAINS AS ONE OF THE MOST CHALLENGING AREAS OF DRUG DEVELOPMENT. ANIMAL AND HUMAN DATA PROVIDE SOUND EVIDENCE THAT BODY WEIGHT IS REGULATED AROUND A PHYSIOLOGICAL "SET POINT," AND TO DATE THOSE THERAPEUTIC APPROACHES THAT… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: EVIDENCE SUGGESTS RECEPTORS MEDIATING CNS RESPONSES TO -AMINOBUTYRIC ACID (GABA) ARE HETEROGENEOUS AND THE DESIGNATIONS OF GABA(A) AND GABA(B) HAVE BEEN ADVANCED TO DIFFERENTIATE MAJOR RECEPTOR SUBTYPES. GABA(A) RECEPTORSARE ANTAGONIZED BY BICUCULLINE (BIC), LINKED TO A PICROTOXIN(PIC)-SENSITIVE… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: SUBSTANTIAL EVIDENCE INDICATES THAT EXCITATORY AMINO ACID (EAA) NEUROTRANSMISSION PLAYS A ROLE IN THE PATHOPHYSIOLOGY OF EPILEPSY, NEURODEGENERATIVE DISORDERS AND THE NEURONAL DAMAGE THAT OCCURS FOLLOWING HYPOXIC OR ISCHEMIC CNS INSULT.OF THE THREE RECOGNIZED EAA RECEPTOR SUBTYPES (QUISQUALATE,… more
Company: ONCOR, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: DIAGNOSIS OF NUMERICAL CHROMOSOME ABNORMALITIES IS ALMOST INVARIABLY BASED ON THE EVALUATION OF MITOTIC CHROMOSOME COMPLIMENTS USING CHROMOSOME BANDING TO FACILITATE INDIVIDUAL CHROMOSOME IDENTIFICATION. CHROMOSOME ANALYSIS HAS BECOME A MAJOR DIAGNOSTIC TOOL IN MANY AREAS OF MEDICINEINCLUDING… more
Company: Potomac Photonics Inc Agency/Program/Year/Phase: DOD / SBIR / 1988 / 2
Abstract: INVESTIGATION OF A NEW TYPE OF RARE GAS HALIDE EXCIMER LASER IS PROPOSED. THE NEW DEVICE IS POTENTIALLY CAPABLE OF CONTINUOUS ULTRAVIOLET OUTPUT AND UTILIZES MICROWAVE DISCHARGE EXCITATION OF MULTIATMOSPHERIC GAS MIXTURES IN NARROW-BORE HOLLOW WAVEGUIDES. RECOMBINATION OF HALOGEN MOLECULES… more
Company: Potomac Research Inc. Agency/Program/Year/Phase: NSF / SBIR / 1988 / 1
Abstract: RESEARCH ON A TECHNIQUE OF THREE-DIMENSIONAL FOURIER MAPPING, BY FREQUENCY SWEEPING, OF MICROWAVE SCATTERING IS PROPOSED. THE RESEARCH IS EXPECTED TO LEAD TO DEVELOPMENT OF AN IMAGING SYSTEM FOR DIELECTRIC EVALUATION AND FOR MEDICAL DIAGNOSIS OF HUMAN ANATOMY. WHILE THERE EXIST MANY IMAGING… more
Company: Prb Assoc., Inc. Agency/Program/Year/Phase: DOD / SBIR / 1988 / 1
Abstract: AS SURFACE SHIP CAPABILITIES IMPROVE, THE PROBLEM OF ASSESSING A SURFACE WARFARE THREAT BECOMES INCREASINGLY IMPORTANT AND COMPLEX. THREAT LEVEL DEPENDS ON NUMEROUS INTERDEPENDENT FACTORS: THE FORCES ARRAYED ON BOTH SIDES, THEIR DISPOSITIONS, AND INTENTIONS; GEOGRAPHY AND OTHER ENVIRONMENTAL… more
Company: QUALITY BIOLOGICAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE LONG RANGE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP SERUM-FREE MEDIA FORMULATIONS FOR THE CULTURE OF HUMAN LEUKOCYTES IN VITRO. THE OBJECTIVE OF PHASE I STUDIES IS TODEVELOP SERUM-FREE MEDIUM THAT WOULD ALLOW MAXIMUM GROWTH AND CYTOTOXIC ACTIVITY OF NON-MITOGEN ACTIVATED HUMAN LYMPHOKINE… more
Company: Quantix Corp Agency/Program/Year/Phase: NASA / SBIR / 1988 / 2
Abstract: LARGE AREA (UNLIMITED SIZE) TWO-DIMENSIONAL POSITION-SENSITIVE (ABOUT 0.1MM) SOLID-STATE NUCLEAR PARTICLE DETECTORS ARE PROPOSED FOR FEASIBILITY INVESTIGATION USING QUANTEX-DEVELOPED ELECTRON-TRAPPING (ET)MATERIALS. IMPINGEMENT OF HIGH-ENERGY (COMPARED TO 2EV) NUCLEAR PARTICLES OR IONIZING PHOTONS… more
Company: Quantix Corp Agency/Program/Year/Phase: DOD / SBIR / 1988 / 2
Abstract: NEW MATERIALS TO DIRECTLY UPCONVERT 1 TO 12 MICRON INFRARED IMAGES TO VISIBLE HAVE BEEN DEVELOPED BY QUANTEX IN THE PAST YEAR. THESE MATERIALS ARE A NEW GROUP OF DOPED SEMICONDUCTORS WHICH HAVE PURPOSELY TAILORED ELECTRON TRAP DEPTHS SELECTED FROM 85 MEV TO 1.3 EV. ONCE THE TRAPS ARE FILLED BY A… more
Company: Quantix Corp Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: RADON FOUND IN INDOOR AIR PRESENTS A GREATER RADIOLOGICAL HEALTH HAZARD TO THE GREATEST POPULATION THAN ANY OTHER RADIATION SOURCE. QUANTEX CORPORATION'S OBJECTIVE IS TO DEVELOP A VERY LOW COST, FEATHERWEIGHT, MAILABLE, ALPHA-PARTICLE DOSIMETER MEDIUM THAT CAN BE EMPLOYED BY THE GENERAL POPULATION… more
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