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State:Massachusetts
Company: Integrated Genetics Inc Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: HUNTINGTON'S DISEASE (HD) IS A PROGRESSIVE, NEURODEGENERATIVE, AUTOSOMAL DOMINANT DISEASE WHICH GENERALLY MANIFESTS ITSELF IN THE THIRD TO FIFTH DECADES OF LIFE. THE GOAL OF THIS PROJECT IS TO DEVELOP A GENETIC LINKAGE TEST FOR THE PRESYMPTOMATIC AND PRENATAL DIAGNOSIS OF HUNTINGTON'S DISEASE. IN… more
Company: Integrated Genetics Inc Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: TRANSGENIC MICE PROVIDE APPROPRIATE MODEL SYSTEMS TO STUDY THE GENESIS, MAINTENANCE, AND TRANSMISSION OF PARTICULAR TYPES OF NEOPLASMS. IN ADDITION, IMMORTALIZED SOMATIC CELLSCAN BE CULTURED FROM TRANSGENIC MICE IN WHICH SV-40 EARLY REGION DNA WAS INTRODUCED INTO EMBRYOS AND WAS TARGETED IN THE… more
Company: Integrated Genetics Inc Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: ERYTHROPOIETIN IS AN IMPORTANT HORMONE THAT REGULATES THE PRODUCTION OF RED BLOOD CELLS. IT IS PRODUCED IN THE KIDNEYIN RESPONSE TO HYPOXIA. SEVERAL ANEMIAS AND CYTHEMIAS ARE ASSOCIATED WITH ABNORMAL LEVELS OF ERYTHROPOIETIN. THE GOALOF THIS PROJECT IS TO DEVELOP A HIGHLY SENSITIVE AND ACCURATE… more
Company: Integrated Genetics Inc Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE LONG-TERM OBJECTIVE OF THE RESEARCH DESCRIBED IN THIS APPLICATION IS TO DEVELOP A UNIQUE TECHNOLOGY FOR THE TRANS-FER OF CLONED GENES INTO THE BOVINE GERM LINE. IN THE LONG TERM, SELECTION OF GENES TO BE INTRODUCED WILL BE AIMED AT PROMOTING ANIMAL LONGEVITY, DISEASE RESISTANCE, ACCELERATED… more
Company: LTI Agency/Program/Year/Phase: ED / SBIR / 1986 / 1
Abstract: WHILE EDUCATORS READILY ACKNOWLEDGE THE POTENTIAL VALUE OF INTEGRATING VOICE AND SOUND INTO COMPUTER-BASED INSTRUCTION, APPLICATIONS OF SPEECH HAVE BEEN SLOW TO DEVELOP. EARLY ATTEMPTS AT CREATING MULTIPLE MODALITY ENVIRONMENTS HAVE BEEN EXPENSIVE BECAUSE OF THE NEED FOR SPECIAL ADD-ON EQUIPMENT AND… more
Company: Lexikos Corp. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: LEXIKOS HAS PROTOTYPE COMMON LISP SOFTWARE ABLE TO SYSTEMATICALLY FIND, MODEL, AND RELATE THE CENTRAL TOPICS OF WELL-FORMED ENGLISH TEXT, THEN RECORD THIS DATA IN A MODULAR WAY SO THAT OTHER SOFTWARE CAN ACCESS IT EASILY. WE PROPOSE USING AN ENHANCED VERSION OF THIS CODE TO SHOW THE FEASIBILITY OF A… more
Company: Lipid Specialties Inc Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: STUDIES IN THE MEDICAL LITERATURE SINCE THE 1970S HAVE STRONGLY SUGGESTED THAT EICOSAPENTAENOIC ACID (EPA) IS A SIGNIFICANT MODULATOR OF THROMBOXANE AND PROSTAGLANDIN ACTIVITY, PRIMARILY IN ITS ROLE AS A PRECURSOR OF THE 3 CLASS OF THROMBOXANES AND PROSTAGLANDINS. A RECENT 20-YEAR EPIDEMIOLOGICAL… more
Company: Lipid Specialties Inc Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE PRIMARY TREATMENT FOR GALLSTONES IS SURGICAL REMOVAL. WITH A 1% MORTALITY RATE AND SUBSTANTIAL HOSPITALIZATION COSTS, A SEARCH FOR LESS EXPENSIVE AND SAFER TREATMENTS FOR GALLSTONE ELIMINATION IS WARRANTED. IT HAS BEEN SHOWN THAT GALLSTONES CONSIST PRIMARILY OF CHOLESTEROL AND THAT THEIR… more
Company: Lipid Specialties Inc Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE PREPARATION OF PANCREATIC TISSUE EXTRACTS REQUIRES THE REMOVAL OF FATS-PRIMARILY TRIGLYCERIDES-FROM CRUDE TISSUE. SUCH EXTRACTED PANCREATIC TISSUE IS OF PARAMOUNT IMPORTANCE IN TREATING CYSTIC FIBROSIS PATIENTS WHO SUFFER FROM PANCREATIC INSUFFICIENCY. IN THE PAST, A VARIETY OF ORGANICSOLVENTS… more
Company: Marko Materials Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: A SCREENING PROGRAM WILL BE CONDUCTED TO IDENTIFY NEW TITANIUM ALLOYS HAVING IMPROVED MECHANICAL PROPERTIES FROM ROOM TEMPERATURE TO 1400 DEG F. THESE ALLOYS WILL BE PRODUCED USING MARKO'S PROPRIETARY RAPID SOLIDIFICATION TECHNIQUE, FOLLOWED BY PULVERIZATION, CONSOLIDATION BY HOT ISOSATIC PRESSING… more
Company: Marko Materials Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: ADVANCED COLUMBIUM ALLOYS HAVING IMPROVED HIGH TEMPERATURE MECHNICAL PROPERTIES AND OXIDATION RESISTANCE ARE OF LONG-TERM INTEREST TO THE U.S. AIR FORCE FOR POTENTIAL APPLICATIONS AS TURBINE VANES IN AIRCRAFT PROPULSION SYSTEMS. THERE IS AN OPPORTUNITY TO DEVELOP IMPROVED COLUMBIUM ALLOYS USING THE… more
Company: MASSACHUSETTS TECHNOLOGICAL LABORATORY Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: Mayflower Communications Company, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: Mccormick Laboratorytories Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE LONG TERM OBJECTIVE OF THIS PROJECT IS TO COMMERCIALIZE A TOTALLY NEW ENDOTRACHEAL TUBE THAT PROVIDES A NEW MEANS TO DETERMINE THE TUBE'S POSITION WITH A SPECIAL SENSING INSTRUMENT. THE TUBE AND SENSING INSTRUMENT CONCEPT HAVE BEEN DESIGNED FOR USE IN PEDIATRIC RESPIRATORY SUPPORT PROCEDURES.… more
Company: MEEKS ASSOCIATES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: WE PROPOSE TO DEVELOP A COMPUTER-BASED SYSTEM FOR THE EARLY DETECTION AND REMEDIATION OF DYSLEXIA. THIS SYSTEM WOULD INCORPORATE ANIMATED COLOR GRAPHICS, DIGITAL AUDIO RECORDING, AND A TOUCH-SENSITIVE DISPLAY. A CHILD USING THIS SYSTEM WOULD RECEIVE RECORDED VERBAL INSTRUCTIONS WHILE WATCHING A… more
Company: Merix Corp Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE PROPOSED RESEARCH IS DIRECTED AT DEVELOPING A NEW AFFINITY ADSORPTION AND CHROMATOGRAPHY TECHNIQUE WHICH OFFERS GREAT PROMISE FOR COMMERCIAL SCALE SEPARATIONS OF BIOLOGICALLY ACTIVE MATERIALS SUCH AS INTERFERON AND GROWTH HORMONE. THE TECHNIQUE IS BASED ON ATTACHING THE AFFINITY LIGANDS TO A… more
Company: Merix Corp Agency/Program/Year/Phase: DOD / SBIR / 1986 / 2
Abstract: U.S. MILITARY FORCES NEED PROTECTION AGAINST CHEMICAL WARFARE AGENTS SHOULD THESE BE DEPLOYED AGAINST THEM IN SOME FUTURE CONFLICT. TO THIS END, AN EFFECTIVE GAS MASK HAS BEEN DEVELOPED WHICH PROVIDES RESPIRATORY PROTECTION AGAINST ALL KNOWN MILITARY TOXIC CHEMICAL AGENTS.THE MASK USES WHETLERITE, A… more
Company: Merix Corp Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: THERE IS A REQUIREMENT FOR AN IMPROVED RADOME MATERIAL, WITH A FINER GRAIN STRUCTURE, GREATER STRENGTH AT ELEVATED TEMPERATURES AND GREATER EROSION RESISTANCE (PARTICULARLY TO RAIN) THAN PRESENT MATERIALS. THIS NEW MATERIAL MUST BE CAPABLE OF BEING FABRICATED INTO INTRICATE SHAPES WITH ACCURATE… more
Company: Merix Corp Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: MEMBRANE BASED INERT GAS GENERATING SYSTEMS FOR INERTING OF FUEL TANK ULLAGE SPACE TO CARRY A LOWER AIRCRAFT PENALTY THAN SYSTEMS BASED ON MOLECULAR SIEVES AND SYSTEMS BASED ON STORAGE OF CRYOGENIC NITROGEN. WITH CURRENT TECHNOLOGY, APPROXIMATELY 30 LBS OF MEMBRANE MATERIAL ARE NECESSARY PER LB/MIN… more
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