Abstract:While the clinical utility of circulating tumor cells (CTCs) for the management of many different types of cancers are being realized, the challenge in selecting them from peripheral blood and enumerating them is daunting due to the exceedingly high numbers of spectator cells (erythrocytes and… more
Company:AQUA GREEN LLCAgency/Program/Year/Phase:USDA / SBIR / 2010 / 1
Abstract:Although baseline methods for growing high-value marine finfish in low salinity recirculating aquaculture systems (RAS) have been developed, the technologies for effective treatment of wastewater from RAS facilities operating at low salinity levels have not been explored to any great extent,… more
Abstract:This Small Business Innovative Research (SBIR) Phase II project's overall goal is to commercialize a robust, continuous culture production system for rotifers (Brachionus rotundiformis; s-type), the major live feed source for marine larval fish. A major bottleneck in the expansion of the marine… more
Abstract:DESCRIPTION (provided by applicant): Between 10% and 20% of the United State population suffer from seasonal influenza each year. While most individuals recover from influenza in one to two weeks, the very young, the elderly and persons with chronic medica
l conditions can develop post-flu pneumonia… more
Abstract:DESCRIPTION (provided by applicant): 7-Butyl-10-aminocamptothecin (BACPT), as a water-soluble dipeptide pro-drug - BACPTDP, is a novel camptothecin analog that has increased activity in hypoxic/acidic tumor tissues, characteristic of fast growing cancers t
hat characteristically have deficient… more
Abstract:The numerous management tools currently employed for disaster response presents a barrier when attempting to share information
across boundaries. This impediment is due to the different reporting formats, data storages, or incompatibility of software being
deployed. Geocent proposes implementing… more
Abstract:We propose the development of a capability which will allow ecosystem managers to share a map view in terms of location, magnification level, and data layers (to include local data and sources) throughout the community of COAST users. This capability will foster collaboration and allow rapid… more
Abstract:Mezzo fabricates high performance micro tube heat exchangers. In this proposal, extremely light weight versions of these heat exchangers made from polymers will be examined for use on high altitude unmanned air vehicles (UAVs). The anticipated weight of these heat exchangers is expected to be… more
Abstract:The objective of this program is to develop techniques to reduce engine cooling system noise levels of the Expeditionary Fighting Vehicle (EFV). Mezzo's approach is to redesign the engine cooling heat exchangers (LTC, HTC, fuel cooler, and condenser) using Mezzo's heat exchanger technology to reduce… more
Abstract:Mezzo fabricates high performance micro tube heat exchangers. In the Phase I program, Mezzo explored substituting the stainless steel micro tubes that typically have been used with polymer micro tubes. Polymer micro tube heat exchangers have significant potential advantages over currently used metal… more
Abstract:DESCRIPTION (provided by applicant): NuPotential will use SBIR funds to improve a patent pending method to reprogram cells using a novel small molecule library. Reprogrammed cells generated using this improved method will be referred to as NuPiPSsm cell
s. In addition, NuPotential will partner… more
Abstract:DESCRIPTION (provided by applicant): NuPotential, Inc. will use NIH STTR funds to generate and validate human Oct-4 gene-targeted reporter cell lines that will provide superior predictive indexing of gene transcription for the identification of efficient reprogramming-competent epi-drugs. To… more
Abstract:DESCRIPTION (provided by applicant): Direct reprogramming of somatic cells to induced pluripotent stem (iPS) cells has been demonstrated by viral transduction of exogenous transcription factors. These initial demonstrations have provided valuable insight into molecular mechanisms of somatic cell… more
Abstract:This Phase I SBIR Project is aimed at determination of the technical feasibility and commercial viability of an Avian Infrasound Detection (passive) and Denial (active and non-lethal) System (AVIDDS) using infrasound energy. The primary purpose of the AVIDDS is system is collision avoidance between… more
Abstract:
Modern technology, particularly computers and weather satellites, and the availability of data provided by coordinated meteorological observing networks, has resulted in enormous improvements in the accuracy of weather forecasting. Satellites, in particular, have given… more
Abstract:DESCRIPTION (provided by applicant): Between 10% and 20% of the United State population suffer from seasonal influenza each year. While most individuals recover from influenza in one to two weeks, the very young, the elderly and persons with chronic medica
l conditions can develop post-flu pneumonia… more
Abstract:This project will develop a field portable nondestructive technique for in-situ monitoring of the health of ceramic armor. The Evisive Scan microwave interference scanning method has been successfully demonstrated in Phase I of the project, where it was demonstrated successfully on Control… more
Abstract:The objective of this proposal is to develop a robust hand-held, data acquisition system for microwave inspection of non-metallic armor on ground vehicles. The system will em-ploy the patented Evisive Scan microwave interference testing method has been dem-onstrated in a portable, work station… more
Abstract:The objective of this proposal is to develop, demonstrate, and field a Non-Destructive Inspection (NDI) Automatic Test Equipment (ATE) for field units and depot to utilize in inspecting and/or repairing compo-site rotor blades. The NDI-ATE is to be field portable, provide results in near real time,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a compact, metalbased, sealed, recirculating, fluid cooling system for electronic devices. Metal-based microchannel heat exchangers (MHEs) have potential advantages over Si-based devices in terms of thermal performance… more
Abstract:A system to provide either continuous 15 kW cooling at -15 C or 100 kW cooling at 20 C is described that is very simple in terms of using only light weight micro channel heat exchangers, two constant speeed pumps (one of which is working at any moment) and some control valves. The system does not… more
Abstract:High efficiency engines that reject waste heat to the atmosphere are needed for high altitude (85,000-100,000 ft), low speed aircraft that are envisioned for DoD applications. Often, a heat exchanger is required to reject the waste heat. The challenges of heat rejection are associated with the fact… more
Abstract:The goal of this proposal will be to demonstrate the viability of a micro tube heat exchanger in an HVAC application on board a Navy vessel. Specifically, a product design sequence will be completed, resulting in R-134a economizer that will provide volume and weight savings over existing… more
Abstract:DESCRIPTION (provided by applicant): NuPotential will use NIH STTR funds to develop and validate a novel epigenetic-based in vitro system for reprogramming bovine donor cells to improve the efficiency of somatic cell nuclear transfer (SCNT). To accomplish
this, NuPotential will alter chromatin… more
Abstract:This Small Business Technology Transfer Phase I research will deveop and commercialize a robust, continuous culture production system for rotifers (Brachionus rotundiformis; s-type). The inability to supply microalgal, zooplankton and rotifers feeds cost-effectively and consistently continues to be… more
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