Abstract:DESCRIPTION (provided by applicant): Currently buprenorphine (BUP) is used in the treatment of opioid abuse and for pain management. It can also be used improperly and abused as an opioid. In the United States, buprenorphine is marketed in sublingual and i
njectable forms. While the drug provides… more
Abstract:Military network environments will be subject to both internal and external threats for the foreseeable future. Internal threats to cyber networks from U.S. personnel receive little attention in comparison to external threats; yet, the consequences can be even more devastating. The lack of tools… more
Abstract:This program is to develop multi-layered,light weight armor alloys systems that offer improved fragmentation and armor piercing performance as compared to any other monolithic structures. Such alloys and laminated configuration will be developed by utilizing advanced computational techniques to… more
Abstract:Two different approaches will be investigated for producing aluminum alloys with a layer structure that have mechanical properties similar to Al 7050-T7 and Al 7075-T6 and greatly improved corrosion resistance. Layered aluminum alloys will be produced using the Novelis-FusionT casting process. … more
Abstract:The objective of this program is develop high strength aluminum alloys ( as high strength as that of 7075-T6) that would not require anodization to achieve corrosion resistance. Among the Al alloy systems, only 7xxx and Al-Cu-Li alloy systems are capable of such a high strength level of 7075-T6… more
Abstract:DESCRIPTION (provided by applicant): Detection of ovarian cancer at Stage I results in 5-year survivals of greater than 90%; however, only 23% of ovarian cancers are diagnosed early, with 67% being diagnosed with metastatic disease. Thus, new markers are b
eing sought to accurate identify patients… more
Abstract:DESCRIPTION (provided by applicant): Periodontal disease has been recently identified as a risk factor for increased morbidity and mortality for systemic diseases such as pancreatic cancer, cardiovascular disease (atherosclerosis, myocardial infarction, a
nd stroke), and diabetes, as well as for… more
Abstract:DESCRIPTION (provided by applicant): Transcutaneous electrical stimulation applications involving high numbers of stimulated muscles have been an area of growing interest in recent years. customKYnetics has been approached in recent months by research gro
ups and stimulation application developers… more
Abstract:This Small Business Innovation Research Phase I project is to develop and commercialize a powerful new diagnostic assay platform for quantitative analysis of plasma from human blood using Differential Scanning Calorimetry. The platform will form the basis for generating novel high-throughput… more
Abstract:DESCRIPTION (provided by applicant): NaugaNeedles LLC in collaboration with researchers from Purdue University are proposing to develop an advanced new Ultra-Soft Atomic Force Microscope (USAFM). This USAFM can gently create images of soft biological sampl
es in buffer solutions with sub-picoNewton… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research(SBIR)Phase II project seeks to overcome the principal impediments of the inconsistent quality of metal matrix composite (MMC) materials from fly ash and aluminum… more
Abstract:DESCRIPTION (provided by applicant): The ability to genetically modify mice through methods of gene transfer in fertilized mouse embryos (transgenic mice) or gene modification in embryonic stem (ES) cells (gene targeting) has dramatically increased the va
lue and use of mice in biomedical research.… more
Abstract:DESCRIPTION (provided by applicant): Antibiotic resistant pathogenic microbes are responsible for thousands of human fatalities worldwide each year. The heightening risk of emerging pathogen resistance in clinical settings promotes the need for discovery a
nd development of new antibiotics with a… more
Abstract:DESCRIPTION (provided by applicant): SCR, Inc. (Louisville, KY) is developing a chronic implantable CPD system to treat HF patients who may be responsive to long-term counterpulsation support. The CPD has been developed for superficial implantation via a p
acemaker incision without the need to enter… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to develop validated, genetic biomarkers to aid in more accurate diagnosis and targeted treatment of schizophrenia and related neuropsychiatric illnesses, including bipolar di
sorder. In Phase I, SureGene demonstrated… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research (SBIR) Phase II project seeks to reduce the cost and risk of manufacturing nanoparticle/resin blends for coatings. Currently nanocoating resin manufacturing… more
Abstract:DESCRIPTION (provided by applicant): The outcome of this SBIR application will be a rat model of colorectal cancer (CRC), which can be used to discover new targets for colon cancer therapy. CRC rats will be produced using Transposagen's novel technology fo
r introducing somatic mutations in rats. A… more
Abstract:DESCRIPTION (provided by applicant): This project aims to rapidly produce rat mutants through a transposon-based method of mutagenesis. The rat is a favored model for many types of human disease for which mice are not suitable. The rat is the most relevant
model for cardiovascular and hypertension… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses the development of a UV curable bulk nanocomposite having enhanced optical and mechanical properties for ophthalmic lenses. The work focuses the incorporation of metal oxide nanoparticles into a transparent polymer to engineer… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project tests the feasibility of using a highly innovative polarized multi-wavelength light extinction spectroscopy approach for on-line non-destructive characterization of coated nanoparticles and nanoparticle agglomerates. From extinction… more
Abstract:This SBIR Phase I project is to prove the feasibility of an innovative weld monitoring technology. This innovative technology is characterized by (1) an innovative non-transferred arc sensor which responds to both surface conductivity and sensor-to-joint distance and can be used to monitor the joint… more
Abstract:Gas Metal Arc Welding (GMAW) is the most widely used welding process. It is also the major process used in shipbuilding. In traditional GMAW and all its modifications, the current which melts the wire is the same as the current which heats the base metal. The base metal heat input is thus… more
Abstract:Orbital pipe welding systems are not true emulation of skilled welders who adjust welding parameters based on observation on the weld pool. This SBIR Phase II project aims at the development of commercial prototype systems which can adaptively adjust welding parameters based on an observation on the… more
Abstract:The objective of the proposed research aims to develop Reduced Order Models (ROMs) (i.e. POD, HB, combined POD and HB) based upon flight data to better predict the aircraft aeroelastic response at next flight condition, e.g. higher Mach number. By incorporating flight test data and using the… more
Abstract:CFD modeling and simulation has been heavily invested in decades of manpower by a large community of researchers. However, the excessive numerical diffusion inherently caused by discretization errors plus the possibly largest/finest grid requirement for rotor wake modeling prevents CFD to be… more
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