Abstract:DESCRIPTION (provided by applicant): Cervical cancer, which is caused by HPV infection, is characterized by the progressive formation of dysplastic lesions, known as cervical intraepithelial neoplasia (CIN). Although vaccinations for the prevention of cervical cancer have been developed, the… more
Abstract:DESCRIPTION (provided by applicant): Amongst the different cancer types afflicting the US population, glioblastoma multiforme (GBM) is a dreadful disease with an overall average survival of 10 months. With about 8,000 new cases per year, representing onlyabout 2% of new cancer patients, this disease… more
Abstract:DESCRIPTION (provided by applicant): Brockman-Hastings LLC seeks to reduce vision loss for glaucoma sufferers by creating a simple, accurate, and clinically acceptable sensor for monitoring intraocular pressure (IOP). Trends indicate that by 2020, approximately 80 million people worldwide will… more
Abstract:DESCRIPTION (provided by applicant): The specific aims of this proposal are to use a newly developed intracellular energy delivery technique to enhance resuscitation, and to study the relationship between tissue high-energy phosphate supplementation and tissue necrosis and apoptosis during… more
Abstract:Recent study by Candes et al. proves that that matrix completion is able to recover the missing entries from a surprising small fraction of random known entries if the matrix admits certain properties. The theoretical advance of the matrix recovery fosters a number of applications such as… more
Abstract:DESCRIPTION (provided by applicant): The present lack of blood-based diagnosis requires AD patients to be subjected to either invasive spinal fluid (CSF) tapping, expensive MRI or PET imaging, or arduous psychological testing, all unsuitable and costly forour elderly. Strategically, we shall address… more
Abstract:Research is proposed for the development of a state-of-the-art computational aeroelastic tool. This tool will include various levels of fidelity and the ability to perform computational uncertainty quantification for data-driven risk analysis and certification. A number of novel reduced-order in… more
Abstract:The proposed work will establish high fidelity computational methods and wind tunnel test model in support of new freeplay criteria for the design, construction and controlled actuation of control surfaces with varying amounts of freeplay and their aeroelastic response. These methods will be… more
Abstract:The need to accurately predict aeroelastic phenomenon for a wide range of Mach numbers is a critical step in the design process of any aerospace vehicle. Complex aerodynamic phenomenon such as vortex shedding, shock-turbulence interaction, separation, etc. dominate at transonic and supersonic Mach… more
Abstract:DESCRIPTION (provided by applicant): With over 8.5% of the U.S. population and 75 million people worldwide meeting the diagnostic criteria for alcohol use disorders (AUDs), alcohol abuse is among the top three preventable public health problems in the U.S.and the world. AUDs, commonly referred to as… more
Abstract:Designing complex systems, such as those used by NASA, requires a coordinated effort among a variety of engineering teams. In order to be successful, the human-computer interactions in these systems need to follow a principle-based design process. In Phase II, TiER1 and Alion propose to continue… more
Abstract:The approach selected to address the development of High Strength Stress Corrosion Resistant Aluminum Casting Alloys is to use A201 and AA2139 as the base alloy and modify/optimize the composition use thermodynamic modeling . Reducing the susceptibility to hot-tearing will be achieved through the… more
Abstract:DESCRIPTION (provided by applicant): Bipolar disorder is an inherently complex chronic illness characterized by recurrent, dramatic mood changes. Management of bipolar disorder typically consists of a combination of medication, therapy, and lifestyle adjustments. However, clinicians lack tools to… more
Abstract:DESCRIPTION (provided by applicant): This FastTrack SBIR proposal aims to disseminate a Functional Electrical Stimulation (FES) technology for stroke ambulation and neuromotor rehabilitation. The FastFES paradigm integrates two rehabilitation approaches,fast-paced treadmill walking and FES, in a… more
Abstract:DESCRIPTION (provided by applicant): Transcutaneous electrical stimulation applications involving high numbers of stimulated muscles have been an area of growing interest in recent years. customKYnetics has been approached by research groups and stimulation application developers requesting high… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a low-cost manufacturing process to produce conductive and high-aspect-ratio probes for atomic force microscopy (AFM). A new fabrication tool with high-precision alignment and in-situ process monitoring sensors will be… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to commercialize a new process to recycle petroleum toxic wastes to clean and inexpensive energy. This Phase II project will scale the improved process by modifying the company?s pilot unit to incorporate the enhancements… more
Abstract:DESCRIPTION (provided by applicant): Most cell culture lines are anchorage-dependent and require surface attachment for proliferation. For industrial production, increased surface area can be provided by microcarrier beads, but the associated increases incost and the resulting complexity of… more
Abstract:DESCRIPTION (provided by applicant): The use of research animals in research has been essential to development of vaccines and study of most human diseases. Modern rodent research is increasingly powerful with the ability to manipulate the genomes of miceand rats such that they closely mimic complex… more
Abstract:DESCRIPTION: Renal transplantation is the preferred therapeutic approach for end organ failure. However, the chronic use of immunosuppressive agents is critical to prevent rejection. The drugs are costly ( 15,000-25,000/year) and have significant toxicities including opportunistic infection, an… more
Abstract:DESCRIPTION (provided by applicant): The laboratory rat is the preferred rodent model in pre-clinical drug studies and encompasses the bulk of accumulated knowledge in drug development. Their larger size facilitates procedures otherwise difficult in mice,including studies using instrumentation,… more
Abstract:nGimat & Oak Ridge National Labs jointly propose to develop safe high-voltage cathode materials for pulsed power applications in the military and commercial sectors. nGimat's versatile NanoSpray Combustion process will be utilized to tailor the bulk & surface composition of the cathode… more
Abstract:AMT Nano, LLC has developed innovative technology for achieving a versatile microrobot platform. The innovation relies on a unique micromolding process, which is low-cost and high-throughput, and high precison. The process achieves versatility by generating deterministic freeform shapes in polymers… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a new method and reactor for continuous and large-scale production of titania and other related metal oxide nanowires. Inexpensive micron scale metal oxide and spherically shaped powders will be converted to nanowires… more
Abstract:DESCRIPTION (provided by applicant): The World Health Organization estimates that over 350 million people are at risk of developing leishmaniasis and infection prevalence is 14 million people in the world. Annually, 2 million people are infected with Leishmania species and 270,000 will die.… more
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