Abstract:DESCRIPTION (provided by applicant): Vitamin D plays a critical role in calcium metabolism and bone health in children and adults. It is now recognized that every tissue and cell in the body have a vitamin D receptor and thus every tissue and cell in the b
ody is a target for vitamin D action.… more
Abstract:DESCRIPTION (provided by applicant): The present lack of blood-based diagnosis requires AD patients to be subjected to either invasive spinal fluid (CSF) tapping, expensive MRI or PET imaging, or arduous psychological testing, all unsuitable and costly for
our elderly. Strategically, we shall… more
Abstract:To overcome the obstacles that previous researchers have been unable to surpass, Talon Technologies has developed a unique hose system that builds on proven high pressure designs. Talon has experience with designing high pressure hoses and understands the challenges facing this project. The concept… more
Abstract:This SBIR Phase I project will develop a biodegradable fabric "pod" for use in reforestation of areas after fires or logging. The company is applying it's expertise in fiber weaving to manufacture an innovative device that allows the growth of seedlings on top of the soil and eliminates the need… more
Abstract:This SBIR project aims at the development of an innovative technology that can be attached to existing submerged arc welding (SAW) systems to monitor and feedback control the depth of weld penetration. Existing SAW systems will be operated using existing welding procedures without modifications. In… more
Abstract:The aluminum alloys have low density, relatively high strength, and high strength-to-weight ratio, which brings some major advantages in marine structure design, fabrication, and operations. However, marine ships are subjected to a complex and severe loading, and the typical failure mode of aluminum… more
Abstract:Research is proposed for the development and implementation of state of the art computational and experimental tools for the investigation of the impact of control surface freeplay on the flutter and limit cycle oscillation characteristics of two-dimensional and three-dimensional wings in subsonic… more
Abstract:This Small Business Technology Transfer Phase I project is aiming at developing and implementing a multiscale composite model to predict the ceramic matrix composite (CMC) response to the impact loading by foreign objects. In particular, the physics-based model will be applied to describe the… more
Abstract:Turbine disks are amongst the most critical components in aero- and naval-vessel engines. They operate in a high pressure and temperature environment requiring demanding properties. Nickel-based supperalloys which have high creep and oxidation resistance at high temperatures are widely used as the… more
Abstract:Research is proposed for the development and implementation of state of the art, reduced order models for problems in
nonlinear aeroelasticity. Highly efficient and accurate aeroelastic simulation tools will be constructed based upon the
mathematical formalism of optimal prediction theory and a… more
Abstract:DESCRIPTION (provided by applicant): A high percentage of the ~ 500,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition(TPN) solution, which is prepared from… more
Company:3 H CompanyAgency/Program/Year/Phase:NSF / SBIR / 2010 / 2
Abstract:This Small Business Innovation Research (SBIR) Phase II project is designed to demonstrate a novel low cost and low energy-consuming CO2 capture technology. The success of CO2 capture and sequestration rely on the development of cost-effective and low energy-consuming CO2 separation system. The… more
In this proposal, TiER1 Performance Solutions and Alion Science and Technology offer to develop A-TAUS (Automated Tool for Assessing Usability in Systems) to assist DHS engineers in improving usability… more
Abstract:In this proposal, TiER1 Performance Solutions and Alion Science and Technology offer to identify requirements and specifications, and implement a proof-of-concept prototype tool to support human factors evaluations. This prototype, called the Human Factors Evaluation Automated Tool (HFE-AT), will… more
Abstract:Future U.S. Information Systems will be subject to increased attacks. These attacks will come from both internal and external threats. As reflected by the budgets for combating these threats, external cyber threats are assumed to be more likely. By comparison, internal threats to cyber networks… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to create a knowledge and training system that will reliably enable trainees and students to learn more material at a faster rate in any sector of society while, in the process: 1) advancing the scientific knowledge of the… more
Abstract:There are many commercially available flexible hoses for use in non-rigid coupling of hydraulic, air, and other piping systems. However, these systems are currently not designed for operating under severe hydrostatic and dynamic pressures experienced by Deep Submergence Systems in their extreme… more
Abstract:DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective trea
tment. Of the 12,000 patients expected to… more
Abstract:DESCRIPTION (provided by applicant): Periodontal disease has been recently identified as a risk factor for increased morbidity and mortality for systemic diseases such as pancreatic cancer, cardiovascular disease (atherosclerosis, myocardial infarction, a
nd stroke), and diabetes, as well as for… more
Abstract:DESCRIPTION (provided by applicant): This proposal will develop a FES-augmented recumbent stepper that elicits lower extremity involvement through electrical stimulation while upper extremity involvement is volitionally controlled by the client. Exercise f
or people with spinal cord injury not only… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a powerful new diagnostic assay platform that will form the basis of a novel high-throughput diagnostic assay for detection and differential diagnosis of six autoimmune diseases: Lupus, Rheumatoid Arthritis, Multiple… more
Abstract:This Small Business Innovation Research Phase I project is to demonstrate the feasibility of batch fabricating high-aspect ratio atomic force microscopy (AFM) probes. These probes have excellent mechanical and electrical properties and are customizable to a wide range of applications and substrates… more
Abstract:As a toxic waste generated during the processing of oil and natural gas, hydrogen sulfide must be disposed of in an environmentally benign manner. Unfortunately the present disposal method, the Claus process, only extracts the sulfur content while wasting the much more valuable hydrogen portion. In… more
Abstract:This SBIR Phase I project will develop a unique packed bed (no catalyst) reactor that can internally maintain temperatures for converting H2S to hydrogen and sulfur. This reactor helps to defeat the equilibrium limitation of the standard Claus Reaction and in addition allows one to capture hydrogen… more
Abstract:DESCRIPTION (provided by applicant): The primary aim is to transfer a biotechnology platform for plant drug discovery from the academic laboratory to industry use (i.e. this application is directly responsive to the lab to marketplace roadmap program). M
any defensive metabolites in plants are… more
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