Abstract:DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective trea
tment. Of the 12,000 patients expected to… more
Abstract:DESCRIPTION (provided by applicant): Periodontal disease has been recently identified as a risk factor for increased morbidity and mortality for systemic diseases such as pancreatic cancer, cardiovascular disease (atherosclerosis, myocardial infarction, a
nd stroke), and diabetes, as well as for… more
Abstract:DESCRIPTION (provided by applicant): This proposal will develop a FES-augmented recumbent stepper that elicits lower extremity involvement through electrical stimulation while upper extremity involvement is volitionally controlled by the client. Exercise f
or people with spinal cord injury not only… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a powerful new diagnostic assay platform that will form the basis of a novel high-throughput diagnostic assay for detection and differential diagnosis of six autoimmune diseases: Lupus, Rheumatoid Arthritis, Multiple… more
Abstract:This Small Business Innovation Research Phase I project is to demonstrate the feasibility of batch fabricating high-aspect ratio atomic force microscopy (AFM) probes. These probes have excellent mechanical and electrical properties and are customizable to a wide range of applications and substrates… more
Abstract:DESCRIPTION (provided by applicant): The primary aim is to transfer a biotechnology platform for plant drug discovery from the academic laboratory to industry use (i.e. this application is directly responsive to the lab to marketplace roadmap program). M
any defensive metabolites in plants are… more
Abstract:DESCRIPTION (provided by applicant): Human nuclear receptor (HNR) ligands have potential value as pharmacotherapies or chemopreventive agents for many hormone-responsive cancers. The primary aim of this STTR is to transfer an academic plant genomics technology into drug discovery, targeting HNR… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will determine the feasibility of a new composite foam material for thermal insulation applications. Residual energy losses due to leaky insulation in the nation's buildings (commercial and residential) contribute to the inefficiency… more
Abstract:DESCRIPTION (provided by applicant): Rats represent the most commonly used physiologically and pharmacological experimental model for studying human disease. The ability to genetically modify rats through methods of gene transfer in fertilized rat embryos
or by gene targeting in embryonic stem (ES)… more
Abstract:DESCRIPTION (provided by applicant): Baculovirus expression vectors have been successfully used to produce thousands of proteins for vaccines, therapeutics, and structure-function studies. Baculoviruses have also been adapted for use as mammalian expressio
n systems and potential gene therapy agents… more
Abstract:DESCRIPTION (provided by applicant): The baculovirus expression vector system (BEVS) is a proven, powerful and versatile method of eukaryotic protein expression. It is used to produce vaccines, diagnostics, and biologically active proteins for a multitude
of research projects. Like all expression… more
Abstract:DESCRIPTION (provided by applicant): Improvements in the safety and efficacy of warfarin therapy will result from intelligent application of knowledge derived from inherited characteristics (CYP2C9 and VKORC1) of individual patients, only when this knowledge is applied… more
Abstract:DESCRIPTION (provided by applicant): The major barriers to preventing or treating Alzheimer's disease (AD) are its unknown pathogenesis/etiology and the lack of an objective, sensitive and specific biomarker of the disease, particularly at the early stageswhen therapeutic interventions would… more
Abstract:DESCRIPTION (provided by applicant): Counterpulsation with an intra-aortic balloon pump has been widely and successfully used as a short term treatment for both acute and chronic cardiac dysfunction. SCR (Louisville, KY) is developing a novel chronic, imp
lantable counterpulsation device (CPD) to… more
Abstract:DESCRIPTION (provided by applicant): This proposal is submitted in response to the program announcement PA-09-080, Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) and intende
d to be directed to the NIDDK, with a… more
Abstract:DESCRIPTION (provided by applicant): The goal is to create site-specific recombinase (SSR)-expressing transgenic rats in an efficient and unbiased manner through a transposon-mediated in vivo gene trap. Rats are very relevant for modeling human biology
and disease because rats, unlike mice,… more
Abstract:DESCRIPTION (provided by applicant): The rat is a favored model for many types of human disease for which mice are not suitable. As opposed to the mouse, rats and humans also share more similarity in their cytochrome P450 genes, making the rat a more usefu
l model for toxicology and pharmacology… more
Abstract:This project will scale up manufacturing systems based on green nanoscience pathways for optically transparent nanocomposites, leading to window coatings with higher thermal efficiency and photovoltaic cells with higher energy efficiency. VDL will migrate its nanocomposite technology, based on spin… more
Abstract:DESCRIPTION (provided by applicant): Pancreatic islet transplantation is a viable approach for the treatment of type 1 diabetes (T1D). However, this therapeutic approach suffers from graft rejection. Dr. Shirwan, founder of ApoImmune, has developed a novel immunotherapeutic approach aimed at… more
Abstract:DESCRIPTION (provided by applicant): There is a significant unmet medical need to provide additional pharmacologic treatments for treatment and prevention of opioid overdose. This Fast Track STTR project proposes to apply drug delivery technologies to develop a novel use for a nasally delivered… more
Abstract:In traditional GMAW and modifications, the current melting the wire is the same as the current heating the base metal. To maintain a minimally acceptable productivity, the base metal heat input is typically much greater than the required to control the distortion at an acceptable or desirable level.… more
Abstract:Research is proposed for the development and implementation of state of the art, reduced order nonlinear aeroelastic models for multidisciplinary/multi-fidelity optimization problems. Highly efficient and accurate aeroelastic simulation tools will be constructed based upon the mathematical formalism… more
Abstract:The proposed research program will develop a physics-based identification, modeling and risk management infrastructure for aeroelastic transonic flutter and limit-cycle oscillations (LCO). This capability will be built upon high fidelity state-of-the-art theoretical/computational methods as… more
Abstract:The proposed work aims at developing techniques that will address the current limitations of Cartesian-based Navier-Stokes CFD schemes by exploring three promising methods of implementing improved wall boundary conditions. The three methods are based on: (1) the diamond stencil approach of Delanaye… more
Abstract:This SBIR aims at developing a high-fidelity, yet efficient and easy-to-use, composite rotor blade and wing section design environment to facilitate rapid and confident aeromechanics assessment during conceptual design stages. A well-known technical barrier for composite rotor blade and wing section… more
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