Abstract:DESCRIPTION (provided by applicant): Alcoholic Liver Disease (ALD) remains a leading cause of death from liver disease in the U.S., and there is still no FDA-approved therapy. Abnormal cytokine metabolism is a major feature of ALD. Elevated serum concentrations of tumor necrosis factor (TNF-) and… more
Abstract:DESCRIPTION (provided by applicant): Periodontitis represents a polymicrobial disease, in which a complex microbial ecology that matures in biofilms in the subgingival sulcus triggers a chronic immune-inflammatory lesion that destroys soft and hard tissues of the periodontium. Despite the great… more
Abstract:Alcoholism is a complex condition in which there are many potential molecular and therapeutic targets for pharmacotherapy. This fast track SBIR contract aims to investigate compounds targeted on the glutamate/NMDA receptor (NMDAR) and the nicotinic receptor for acetylcholine (nicAChR). These… more
Abstract:We propose the development of a simple, low cost technology for the field placement of ultra-high performance concrete (UHPC) that consists of a modified Gunite system and an improved UHPC formulation. The Gunite system includes modifications that overcome a number of problems related to the… more
Abstract:DESCRIPTION (provided by applicant): The baculovirus expression vector system (BEVS) is a proven, powerful and versatile method of eukaryotic protein expression. It is used to produce vaccines, diagnostics, and biologically active proteins for a multitudeof research projects. Like all expression… more
Abstract:DESCRIPTION (provided by applicant): We have developed a protocol that reproducibly induces transplantation tolerance in individuals undergoing a living related donor kidney transplant. Three subjects have been off all immunosuppression for 10 months, 2 months, and 1 month respectively and have… more
Abstract:DESCRIPTION (provided by applicant): The major barriers to preventing or treating Alzheimer's disease (AD) are its unknown pathogenesis/etiology and the lack of an objective, sensitive and specific biomarker of the disease, particularly at the early stageswhen therapeutic interventions would… more
Abstract:DESCRIPTION (provided by applicant): Heart failure (HF) remains one of the largest unsolved problems in health care today and continues to increase in incidence and cost ( 34.8 billion in US in 2008). Prognosis remains limited especially in patients with advanced heart failure. Transplantation is… more
Abstract:DESCRIPTION (provided by applicant): There are an estimated 26 million Americans with early chronic kidney disease (CKD). Early diagnosis and treatment are the only cost-effective means to reverse this growing problem. NIH recognizes the challenge to diagnose CKD early during its initiation and… more
Abstract:ABSTRACT: nGimat proposes to develop a novel technique to sinter ceramic films deposited onto metallic substrates by combining two efficient and inexpensive techniques: flame sintering and field-assisted"flash"sintering. The creativeness of this approach lies in the concept to use a… more
Abstract:DESCRIPTION (provided by applicant): Left ventricular assist devices (LVADs) are increasingly applied to treat advanced heart failure, demonstrating improvement of morbidity/mortality and quality of life. Right heart failure (RHF) affects up to 40% of LVADpatients and significantly contributes to… more
Abstract:In the context of post-combustion CO2 capture processes, solvents with fast CO2 absorption rates will require more energy for regeneration. This challenge is exacerbated when aqueous solvents are applied to the capture of post-combustion CO2 from a utility gas stream, which contains such unique… more
Abstract:Future space exploration energy-storage needs span a wide range of requirements. NASA's Exploration missions will require safe, human-rated, high specific energy, high energy density and high efficiency-storage systems that can be used in space and on the moon and Mars. These energy storage… more
Abstract:This Small Business Innovation Research Phase I project will develop a novel nano-scale process for synthesizing sulfur infused carbon composite cathode materials to produce high-energy density lithium-sulfur (Li-S) secondary batteries with a high rate of charge/discharge and extraordinarily long… more
Abstract:This Small Business Innovation Research Phase I project will address issues related to the development of high-energy lithium-ion batteries. Today, mobile devices require faster performance and smaller sizes for greater portability. However, the faster processors in these devices impose energy… more
Abstract:NOHMs Technologies proposes to demonstrate the feasibility of developing a novel Lithium-Sulfur chemistry for electrical energy storage that provides high charge and discharge rates, high cycle life, and high energy density. The proposed technology is based on innovative sulfur-infused carbon… more
Abstract:DESCRIPTION (provided by applicant): In the absence of effective, approved vaccines or therapeutic measures against dengue and other mosquito borne pathogens, public health efforts must focus on the control of mosquito vectors that are required for transmission. Unfortunately, effective control… more
Abstract:Okeanos Technologies is developing a desalination system that used Ion Concentration Polarization (ICP) elements and modular arrays. ICP can separate water from solutes and contaminants far more efficiently than Reverse Osmosis (RO) or Electrodialysis(ED) because no extreme hydraulic pressures or… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project focuses on development of low power consumption, bistable memory nematic liquid crystal display (LCD) devices for e-book and mobile applications, based on the micro-engineered surface alignment (MESA) technology. The MESA-LCD… more
Abstract:Hitron Technologies (HTI) proposes to develop a new solid state, light weight, high quantum efficiency, low noise, and high bandwidth Nanoantenna-Enhanced Organic PhotoDetector (NEOPD), based on an innovative design of nanoantenna and its novel integration with organic photomultiplication (OPM)… more
Abstract:Hitron Technologies, Inc. (HTI), collaborating with University of California at Riverside (UCR), proposes to develop a solar blind Ultraviolet Communication (ULCO) System for battlefield casualty management. The ULCO allow secure, encrypted, high data rate, and two-way communication between a medic… more
Abstract:DESCRIPTION (provided by applicant): Traditional approaches to drug development for Alzheimer's disease are becoming increasingly expensive and in many cases disappointingly unsuccessful. Based on preliminary in vitro and in vivo studies we have identifieda novel lactam derivative of the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to eliminate the use of heat during the process of spray drying liquid emulsions into powders. Typically, a liquid emulsion consists of a high-value liquid ingredient emulsified with a carrier system that when dried captures the… more
Abstract:This Small Business Innovation Research Phase I project entitled ?Smart Filter for Fast Chemical Reaction Clean-up? tackles an important problem in the manufacturing industry, namely, the labor-intensive nature of chemical synthesis and its hazardous conditions, which, unfortunately, have not… more
Abstract:CEPEDA's Shipboard Cardboard Preprocessing System utilizes modular sensing and stripping sections that ensure all tape and plastic labels are removed from the input cardboard. An innovative sensor has been conceived and tested on the bench top that can accurately distinguish tape and labels on… more
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