Abstract:PROJECT SUMMARY Prenatal alcohol exposure is the leading preventable cause of birth defects in the United States, producing an array of neurological, behavioral and physical abnormalities collectively known as fetal alcohol spectrum disorders (FASD). Earlyintervention and treatment programs have… more
Abstract:Future particle physics experiments at the high energy frontier, such as LHC, HL-LHC, ILC, CLIC or Multi-TeV Muon Collider, will all require silicon detectors capable of reconstructing charged particle trajectories with high accuracy in the presence of significant high occupancy. These experiments… more
Abstract:The Navy needs an optical repeater based upon the NGCON (MIL-PRF-64266) because the optical power loss budget on military aircraft is demanding. A bi-directional optical amplifying repeater would address the optical loss issue of connecting a fiber optic link in the aircraft network. Challenges… more
Abstract:Problems of large-scale nonlinear optimization are central to the solution of difficult and novel problems that arise from the need to distribute electric power in the most efficient and reliable way. In recognition of the importance of optimization in this area, DOE & apos;s Office of Advanced… more
Abstract:DESCRIPTION: Fucosylation plays an important role in much cellular process. Fucosylated oligosaccharides in the cell are involved in various types of biochemical recognition processes and in microbial infections, toxin entry, and cancer cells metastasis.These properties make these carbohydrates… more
Abstract:DESCRIPTION (provided by applicant): Prostate cancer affects one in every six men and remains the second leading cause of cancer related mortality in men. Permanent interstitial brachytherapy, the permanent placement of radioactive seeds in the prostate, is widely used in the treatment of prostate… more
Abstract:ABSTRACT: For navigation of space platforms under GPS denied conditions, there is a need for micro-inertial sensors, with better accuracy and smaller volume and weight than the state of the art. We at Digital Optics Technologies (DOT) have been developing a superluminal ring laser gyroscope (SRLG)… more
Abstract:Under the work proposed here, we will develop a physics based comprehensive software for modeling the behavior of a diode pumped alkali laser: DPAL. The software will be designed primarily for a He-Rb DPAL. However, it could easily be applied to DPALs based on other alkali atoms, such as Cs. … more
Abstract:ABSTRACT: As integrated circuits technologies scale down to deep nanometer regime, conventional transistors and interconnect are approaching their fundamental physical and material limits. One of the potential directions for the next generation nanoelectronic applications is the adoption of… more
Abstract:ABSTRACT: A superluminal ring laser gyroscope (SRLG) can improve the accuracy of rotation sensing by nearly five orders of magnitude. The same mechanism can be used to produce a superluminal ring laser accelerometer (SRLA), with a similar improvement in accuracy. Under Phase I, we have… more
Abstract:ABSTRACT: For GPS denied navigation, there is a need for developing inertial measurement units (IMU), employing gyroscopes and accelerometers, with better accuracy and/or smaller volume and weight than the state of the art. Under Phase I, we have established the feasibility of realizing a… more
Abstract:DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) involve chronic inflammation of all or part of the digestive tract. Symptoms may include abdominal pain, severe diarrhea and malnutrition. IBD primarily includes ulcerative colitis (UC)and Crohn's disease (CD). In the West,… more
Abstract:DESCRIPTION (provided by applicant): Osteoporosis is a major public health threat. National Osteoporosis Foundation estimated that the US national direct expenditures for osteoporotic hip fractures were at 17 billion in 2005 and it would increase to 25billion in 2025. Current treatments for… more
Abstract:DESCRIPTION (provided by applicant): Human death investigations must by law be properly implemented even when the decedent is involved in or near to the scene of a hazardous materials emergency. This project intends to develop worker health and safety training for those staff of coroners and medical… more
Abstract:The primary objective of Phase I work performed by the team of CU Aerospace and the University of Illinois is to produce a powerful and easy to use, parallel, fluid-dynamic, chemical-kinetic, and optical simulation software package that will function on any modern computational platform (Unix, Linux… more
Abstract:CU Aerospace proposes the ground test validation of a nanosat primary propulsion subsystem using non-toxic propellant with 3-axis ACS for orbit change and/or de-orbit capability, precision maneuvering, and drag makeup. Our approach, called the CubeSat High Impulse Propulsion System (CHIPS),… more
Abstract:ABSTRACT: CU Aerospace (CUA) and team partner the University of Illinois at Urbana-Champaign (UIUC) propose to perform research, development and demonstration of energy management optimization tools based upon existing UIUC and CUA expertise to expand the operational envelope of military and… more
Abstract:In 2011, there were 60,000 dairy farms in the US. Of there, 56,600 had herds of fewer than 500 animals. Currently, manure digester installations are only considered economical for herds of at least 500 animals. There require turbine or diesel generator sets of 100 Kilowatt size and larger. The… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project is aimed at increasing the throughput of a novel single-cell technology based on nanofountain probe electroporation (NFP-E). Progress in biotechnology research in recent years has shown promise for cell reprogramming and extremely… more
Abstract:DESCRIPTION (provided by applicant): The clinical impact of the 5 million annual surveillance colonoscopies (follow up of previous neoplasia) is remarkably low (gt90% without significant neoplasia). Juxtaposed with this is the alarmingly frequent occurrence of colorectal cancers (CRCs) in between… more
Abstract:DESCRIPTION (provided by applicant): The goal of this small business innovation research grant is to develop and commercialize a highly accurate, minimally invasive risk stratification technique for colorectal cancer (CRC) that is simple enough to be performed by the primary care provider during an… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses a critical need for accurate patient diagnosis in the development of effective therapeutics for Alzheimer's Disease and other dementias, and in patient treatment. The high variability of patients selected for dementia… more
Abstract:Volatile organic compounds (VOCs) and toxic industrial chemicals (TICs) both pose a significant threat to DoD personnel both in the field as well as in established infrastructure such as large buildings. Current VOC/TIC protection technologies suffer from incomplete removal of contaminants, high… more
Abstract:This Small Business Innovation Research Phase II project will result in the continuing development of novel ultrafast, highly selective, high permeability ion-exchange fiber composites (IXFCs) for removing perchlorate from drinking water. The proposed material removes perchlorate 10-100 times faster… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a state of the art 3D imaging system to objectively assess, track and archive gait, balance and range of motion. The prototype will be designed for use by a professional health care provider, such as a physical therapist.… more
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