Abstract:WSSV is the most serious disease in farmed marine shrimp causing considerable financial losses throughout the last decade across the globe. It infects a wide variety of crustacean hosts including numerous species of wild and cultured marine shrimp, crayfish, and prawns. Although a multitude of… more
Abstract:DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively alt
er the expression level of any desired gene… more
Abstract:DESCRIPTION (provided by applicant): Sarcopenia, defined as age related loss of muscle mass and muscle function and strength, is very prevalent among the elderly. Sarcopenia is one of the largest public health problems facing a rapidly increasing, aging po
pulation in the United States and leads to… more
Abstract:DESCRIPTION (provided by applicant): With the considerable success of our phase 2 SBIR, we have achieved the completion of lung image analysis software that segments and thoroughly measures the lungs and their five lobes along with the airway tree. We have recently just achieved 510(k) FDA… more
Abstract:DESCRIPTION (provided by applicant): The synthesis of carbohydrates remains a complex exercise that involves tremendous labor and large amounts of expensive building blocks and reagents. Even once a process for making a carbohydrate has been developed, manufacture of that molecule in all the… more
Abstract:Large scale training exercises involve many trainees at various stages of their training maturity and at various levels of skill. Problems arise in large scale exercises when less mature or lower skilled trainees are exposed to training scenarios that are too advanced or too complex for their level… more
Abstract:This proposal describes the proposed implementation of the concept of the Quality of Training Effectiveness Assessment (QTEA) system. This concept was developed in Phase I (N074-028-0065). Currently, VE design is guided by subjective design models that involve multiple design iterations and focus on… more
Abstract:Today"s Warfighter often carries an inordinate load that can lead to injuries and encumbered performance. Equipment is distributed among squad members with little, if any regard for differences in strength and anthropometry. Consequently, the current focus on human-centric design requires a… more
Abstract:DESCRIPTION (provided by applicant): If left undetected and untreated, reduced vision in one eye can lead to monocular blindness in an amblyopic eye. Most vision screening is conducted on children once they have started kindergarten; this is after the crit
ical detection period for the treatment of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop sensing technology capable of continuously monitoring concentrations of critical metabolites during protein expression with the yeast Pichia pastoris. Presently, continuous monitoring is unavailable and this process is… more
Abstract:We hypothesize that the application of the broad-spectrum immune-stimulatory and -modulatory HyperAcute alphaGal Adjuvant Technology will enhance the potency and effectiveness of VEEV vaccine candidates. To complement the exciting preclinical and clinical results obtained with alphaGal-modified… more
Abstract:In the Phase I effort a Galfenol-based slotted cylinder projector (SCP) device was conceived utilizing an existing PZT SCP design and analytical modeling to determine the geometry requirements necessary to achieve the performance specs: 210 dB source level, 750 Hz resonance frequency, 200 Hz… more
Abstract:This Small Business Innovation Research Phase II project will build, field test, and prepare for commercialization, a prototype industrial tub grinder with integrated high inertia flywheel technology that will reduce the consumption of diesel fuel in recovering woody biomass. Low-weight,… more
Abstract:Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) costs the swine industry approximately $560M annually through reproductive loss in mature females and respiratory disease in growing pigs. There is a need for new vaccines for PRRSV to battle the strain evolution and heterogeneity of this… more
Abstract:DESCRIPTION (provided by applicant): In contrast to the conventional wisdom that the interior problem does not have a unique solution, in 2007 we developed and patented the interior tomography technology (exact and stable interior reconstruction from x-ray
projection data associated with only lines… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project is to develop a low cost educational Particle Image Velocimetry (ePIV) suite including both hardware and software for fluid science and engineering education at university undergraduate and graduate school levels. The proposed PIV is… more
Abstract:DESCRIPTION (provided by applicant): Indolamine 2,3-deoxygenase enzymes (IDO-1 and IDO-2) play important counter-regulatory roles in the immune system. IDO-mediated tryptophan catabolism induces T cell suppression, which plays a physiological role in suppr
essing autoimmune and allergic diseases, as… more
Abstract:During initial design studies, parametric variation of vehicle geometry
is routine. In addition, rotorcraft engineers traditionally use the wind tunnel to evaluate and finalize designs. Estimation of rotor tunnel
blockage is significantly more complex than bluff body corrections as the correction… more
Abstract:Today's Warfighter often carries an inordinate load that can lead to injuries and encumbered performance. Equipment is distributed among squad members with little, if any regard for differences in strength and anthropometry. Consequently, the current focus on human-centric design requires a… more
Abstract:This Small Business Innovation Research Phase I project is for the development of technology to crystallize proteins using less sample and with higher speed and success than current high throughput protein crystallization methods. Protein crystallization is an intermediate step in determining the… more
Abstract:The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift… more
Abstract:Determining meat quality attributes in food animals is essential for genetic selection, sorting, and marketing. Ultrasound techniques have the potential to benefit the swine industry for improvements in both quality and yield measures by non-destructive means. There is a need to continually improve… more
Abstract:This Small Business Technology Transfer Phase I project will develop algorithms for a quality control system for colonoscopy (a procedure where the mucosa of the large bowel is inspected via a flexible tube with a camera on it) that has contributed to a marked decline in the number of colorectal… more
Abstract:Etrema Products, Inc. and Applied Research Laboratory at The Pennsylvania State University demonstrated during Phase I that by utilizing the "delta-E" effect in magnetostrictive materials, the resonant frequency of a split ring transducer can be shifted by over 200 Hz for a low frequency transducer.… more
Abstract:The Phase I effort successfully developed an integrated magnetostrictive transducer/amplifier module concept to meet these performance goals: broad bandwidth (7-30 kHz), compact size (approximately 1/2 wavelength at the center frequency), at least 30 Watts output power, and high efficiency. … more
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