Abstract:DESCRIPTION (provided by applicant): A policy statement by the World Health Organization notes that, the male latex condom is the single, most efficient, available technology to reduce the transmission of HIV and other sexually transmitted infections. Unfortunately, despite decades of condom… more
Abstract:Access to a library of structurally defined N-glycans is an urgent scientific need for glyco-arrays for rapid analysis of carbohydrate binding proteins (CBPs), development of diagnostics and therapeutics for many diseases. However, only a small number ofN-glycans are currently commercially… more
Abstract:The innovation in this project is the design and development of a novel Skills- and Assessments-Based Learning Environment (SABLE) to meet the needs of teachers, school districts and parents in helping high school students develop problem-solving skills. Currently, US students' poor performance… more
Abstract:DESCRIPTION (provided by applicant): HIV/AIDS remains a major health problem and there is a need for effective and durable HIV vaccines. Establishing potent and durable antibodies (Ab) that have neutralizing and non-neutralizing mechanisms can contribute to the prevention of mucosal HIV infection.… more
Abstract:DESCRIPTION (provided by applicant): Triple negative breast cancer (TNBC), which includes tumors lacking estrogen, progesterone, and HER-2 receptor proteins, represents 15-20% of all breast cancer diagnoses in the US, and is one of the most challenging cancers for developing an effective therapy… more
Abstract:DESCRIPTION (provided by applicant): There is a great need for new therapies for Crohn's disease (CD), which is a chronic, relapsing and tissue destructive inflammatory bowel disease (IBD). Estimates indicate that there are gt 1 million annual cases of IBDin the United States, 50% of which… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to complete development of a long-term, universal Apical Access System (AAS) to improve clinical outcomes and expand the role of left ventricular assist device (LVAD) therapy. The treatment of end stage heart failure (HF) is the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will address the demand for new and evolving approaches to alleviate shrinking drug pipelines and costly failed human safety trials and recalls by implementation of new technologies to transform complex human stem cell-derived neural… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a mechanically-active soft tissue reinforcement device using a shape-memory fabric to improve the tissue quality of chronic rotator cuff tears. With chronic tears, the rotator cuff has degenerated to a point that prevents… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will prove the technical and commercial feasibility of a single-use polymer microarray for electromechanical transfection of biological cells. Alternative gene transfer solutions are needed to access the potential held in… more
Abstract:DESCRIPTION (provided by applicant): This Fast-Track SBIR proposal submitted by SoloHealth of Duluth, Georgia, requests grant funds to build and test a multifunction health-screening kiosk. Our current kiosk prototype, EyeSite, has demonstrated efficacy inreaching low income, high health disparity… more
Abstract:Goals of 80% clean energy production for the United States by 2035 and 20% of the countrys power being supplied by wind energy by 2030 imply nearly a tenfold increase in wind power production. This means that the need for forecast information will extend to longer projection windows with increasing… more
Abstract:Existing security technologies fail or have a significant capability gap in detecting and stopping malicious traffic. Based on the new insight that traffic by malware is not directly initiated by user activities on a computer, Security Axioms has developed a new solution called Gyrus. Based on… more
Abstract:DESCRIPTION (provided by applicant): This application is to deliver high-performance, GPU-enabled computation and visualization software tools to neuroscientists. Today, there are an estimated 1.5 million life science MATLAB users, with a substantial portion of those using MATLAB to solve… more
Abstract:This Small Business Innovation Research Phase II project aims to extend work in developing computational music systems that will automatically analyze and re-synthesize digital music for the purpose of transforming a linear and passive music listening practice into an interactive, expressive and… more
Abstract:NanoPlatelets (NPs) created of metal hydroxides present entirely new and previously unknown set of morphologes/properties and are a virtually new frontier and unstudied field of Material Science and may be leveraged into many of todays DoD and Comercial Technical Challenges and applications. Case in… more
Abstract:Conflicts within the US military between roles and responsibilities, the use of NGOs on the battlefield, and the role of host nation and allied forces in a time of transition between combat and non-combat only increase the complexity of the PMESII management issues. After a decade of war and an… more
Abstract:With the advent of glass cockpits in the CH-47F, UH-60M and AH-64D Block III, the Army has recognized the opportunity to control Unmanned Aircraft Systems (UAS) from the cockpit of its manned aircraft. The combined Manned Un-Manned (MUM) team promises to provide the Army aviator with improved… more
Abstract:Obesity and osteoporosis are major public health concerns due to their prevalence in our increasingly sedentary and aging society. In the U.S. today, an estimated 55% of people 50 and older are at risk for developing osteoporosis. Because as much as 20% of bone mass can be lost in the first five to… more
Abstract:Aircraft, missiles, and vehicle structures are susceptible to corrosion. Engines, transmissions, blades, rocket motors, canisters, and other system components include materials that degrade over time and are not often checked. Recently, the application of condition-based maintenance (CBM) techniques… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project investigates high-temperature wirelessly interrogated acoustic sensors for monitoring insulated structures such as piping and storage vessels that are in difficult to access locations and operate at elevated temperatures. Current 2-D… more
Abstract:This SBIR effort seeks to develop a structural health monitoring system that can monitor structural components of vehicles that are subjected to possible blast loading conditions and high-velocity impacts. The system provides the following characteristics; capable of capturing real-time stress… more
Abstract:DESCRIPTION (provided by applicant): The manufacturing of recombinant protein-based biopharmaceuticals is a complex, labor and capital intensive endeavor. It currently is accepted that the use of mammalian cells is a requirement for the production of mosthuman proteins, which typically contain… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to conduct late-stage preclinical studies to support a pilot clinical trial of hematopoietic stem cell transplantaton gene therapy for hemophilia A. In a series of recent studies, wehave shown that the transplantation of… more
Company:Area I, IncAgency/Program/Year/Phase:NASA / SBIR / 2012 / 1
Abstract:The Area-I team has developed and fabricated the unmanned Prototype-Technology Evaluation and Research Aircraft or PTERA ("ptera" being Greek for wing, or wing-like). The PTERA is an extremely versatile and high-quality, yet inexpensive flight research testbed that serves as a bridge… more
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