Abstract:DESCRIPTION (provided by applicant): The practice of modern medicine relies heavily on effective antibiotic therapy to combat bacterial infections. In their absence, many surgeries and chemotherapeutic regimens used to combat cancer and suppress chronic inflammatory conditions would simply not be… more
Abstract:DESCRIPTION (provided by applicant): The overarching aim of the proposed project is to empower autism investigators to (1) make more effective use of data locally and (2) more efficiently exchange data with the scientific community. This will be achieved by delivering an open-source integrated data… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project has the objective of demonstrating thermal interface material (D-TIM paste) at least twice as effective in use in packaging electronics with medium and high power loads as prior material. A major focus is on enabling novel mode of heat… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project addresses the timely need to develop new and robust in silico tools for the prediction of skin sensitization potency of commercial chemicals. Currently, there are no reliable and broadly applicable alternatives to the costly and… more
Abstract:There is a need to achieve 10^-9 reliability for actuators for critical aerospace applications and this precludes single point failure for all but the simplest and most reliable electrical and mechanical components. LC Drives proposes a method of constructing a high reliability linear actuator for… more
Abstract:The overall goal of this proposed program (through Phase III) is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation. It will be able to monitor the drug active pharmaceutical ingredient (API) and its degradation product concentrations as a function of… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a prototype foodborne pathogen analyzer that will employ a novel credit card sized sampling device to extract, detect, identify, and quantify the presence of specific pathogens in food matrices in 1 - 2 hours at the… more
Abstract:We propose to carry out a three-phase R & D project leading to a scalable, easy-to-use Cohort Builder software tool making it possible for clinical practitioners and quality assurance personnel to carry out comparative health research studies quickly and effectively, without the need for… more
Abstract:Sustainable Innovations has developed an innovative concept for highly efficient, reliable, potable water production based on technology from a commercial line of hydrogen recovery and compression systems the company is developing. This Electrochemical Dehumidification and Life Support System… more
Abstract:Sustainable Innovations, LLC, is developing an Electrochemical Methane Generator (EMG), which comprises a novel method of converting CO2 and H2O to hydrocarbon fuels (such as methane) and O2. When powered by a renewable energy source, such as solar or wind power, it can provide a method for… more
Abstract:Sustainable Innovations is developing a technology for efficient separation and compression of hydrogen gas. The electrochemical hydrogen separator and compressor can actively remove hydrogen from a mixture and compress it to high pressure for storage or use. In applications where helium is used as… more
Abstract:Advanced x-ray observatories such as IXO and GenX will require thousands of thin shell mirror segments produced by replication using convex mandrels. Quality and cost effective manufacturing of these segments is proportional to the speed and effectiveness of the metrology we use in manufacturing and… more
Abstract:Amastan, in collaboration with the University of Connecticut, proposes to make high temperature phase stable and CMAS resistant coatings of lanthane hexaaluminate (LaMgAl11O19) material as a suitable substitute to YSZ top coat for thermal barrier coating applications. These coatings, although… more
Abstract:Historically, operation of the mid-frequency active sonar in littoral regions has presented sonar operators with challenges due to the complex nature of the ocean acoustic environment in shallow waters. Although there are complex reasons for the appearance of clutter, research has shown that… more
Abstract:DESCRIPTION (provided by applicant): Advancements in micro- and Nanotechnology have led to a myriad of direct detection schemes and sensitive transducers for biological assays. Indeed, nano-scale transducers with capabilities to detect single cells have already been demonstrated. However, the… more
Abstract:DESCRIPTION: We intend to refine the affinity-reagent discovery process so that it is not only cheaper and faster than currently possible, but also so that we produce reagents that are more versatile and useful than current monoclonal antibodies. We propose to use in vitro combinatorial… more
Abstract:DESCRIPTION: Highly automated and accurate analysis of pesticides residuals is essential to ensure the safety of human foods and animal feeds. Recent advancement in High Resolution Mass Spectrometry (HRMS) hardware systems have made it possible to screenfor hundreds of these target compounds within… more
Abstract:DESCRIPTION (provided by applicant): Persistent pain is the number one reason that patients access the healthcare system according to the National institutes of Health. Pain seriously affects patients' quality of life and is associated with secondary morbidities such as depression, anxiety, and… more
Abstract:DESCRIPTION (provided by applicant): This is an SBIR Phase I proposal is to test the feasibility of developing drug-like small molecules that are positive allosteric modulators of the NR2D subtype of the NMDA receptor (NR2D PAMs) for the purpose of treating impulsivity disorders, notably ADHD. The… more
Abstract:DESCRIPTION (provided by applicant): Unhealthy behaviors such as smoking, medication non-adherence, and lifestyle habits leading to obesity are major contributors to premature morbidity and mortality among the U.S. population. Participation rates in programs designed to improve these behaviors are… more
Abstract:DESCRIPTION (provided by applicant): The objective of this phase I STTR application is to continue assessment of the relevance and feasibility of Nogo decoy receptor therapy for the treatment of glaucoma. The secondary objective is to obtain pharmacokinetic data important for designing additional… more
Abstract:DESCRIPTION (provided by applicant): Cardiomyopathy is an anatomic and pathologic condition associated with muscle and electrical dysfunction of the heart, usually with inappropriate ventricular hypertrophy or dilatation. There are various causes of cardiomyopathy, many of which are genetic. Dilated… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project demonstrates the feasibility of a sketching system that bridges traditional drawing and three-dimensional modeling, offering a novel way to develop, explore and share visual ideas in 3-D. Using a fusion of hand-drawn strokes and… more
Abstract:Autism Spectrum Disorders (ASDs) are severe neurodevelopmental disabilities characterized by deficits in social and communication skills and the presence of restrictive, repetitive behaviors. For the 80 percent of individuals with ASDs who speak, prosody—the rhythm, stress, and intonation of… more
Abstract:The energetic material community has a need to produce energetic materials in varying particle sizes and morphologies. Control of particle and morphology allows the formulator to investigate various aspects of processing and performance associated with the energetic material. Unfortunately,… more
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