Abstract:The volume of meteorological data that is available to fleet users has increased to the point where data fusion and visualization tools must be developed in order to analyze this data in an efficient and timely fashion. These tools should provide a simple, user-friendly interface with flexibility in… more
Abstract:THE PURPOSE OF THE PHASE I STUDY IS TO EXPLORE A NOVEL APPROACH FOR INFLUENZA VIRUS VACCINATION BY USING MICROENCAPSULATED ANTIGENS ADMINISTERED BY THE ORAL OR INTRANASAL ROUTE IN ORDER TO INDUCE A PROTECTIVE MUCOSAL IMMUNE RESPONSE. MICE WILL BE IMMUNIZED WITH PURIFIED INFLUENZA VIRUS TYPE A H3N2… more
Abstract:We will apply a novel adjuvant to the production of an effective, safe vaccine against PIV3. The proposed adjuvant is a proprietary formulation of microcrystalline cellulose, starch, and sugar. We will use a hamster model to test the ability of the novel adjuvant to enhance the immune response to… more
Abstract:The long term objective is to develop a commercial trivalent glycoprotein subunit vaccine for parainfluenza viruses. Because of the high cost of preparing these glycoproteins, a means for achieving an enhanced immune response is an important objective, and it is the immediate focus. The… more
Abstract:The long term objective is to develop a commercial subunit vaccine for human respiratory syncytial virus (RSV). Because of the high cost of preparing these glycoproteins, a means for achieving an enhanced immune response is an important objective, and it is the focus. Biocompatible and biodegradable… more
Abstract:The long term objective is to induce a protective mucosal immune response to prevent HIV-1 infection. We will immunize orally with recombinant defective SIV-like particles entrapped in microcapsules of lactige-glyco- lide copolymer in order to stimulate a mucosal immune response in mice. The… more
Abstract:The long term objective is to develop a commercial vaccine for the prophylactic treatment of sexually transmitted Chlamydia trachomatis. Parenteral or oral delivery of free antigen does not protect against genital infection and, therefore, development of an antigen delivery method that induces a… more
Abstract:The long term objective is to develop a commercial subunit vaccine against MV infection. Because of the high cost of preparing the surface antigens, a means for achieving an enhanced immune response is an important objective and is the focus. Biocompatible and biodegradable microspheres consisting… more
Abstract:THIS PROPOSAL IS TO DETERMINE THE SPATIAL RESOLUTION OF A NEW TYPE OF MULTI-DIMENSIONAL X-Y DETECTOR WHICH PROVIDES THE POSITION IN AN X-Y PLANE OF NEUTRAL PARTICLE INTERACTIONS FOR USE IN AIRPORT SECURITY SYSTEMS FOR INSPECTION OF SEALED LUGGAGE.
Abstract:CONSTRUCTION AND ASSEMBLY OF LARGE STRUCTURES WILL REQUIRE USE OF VARIOUS METAL-JOINING PROCESSES. WELDING IS ONE OF SEVERAL METHODS UNDER CONSIDERATION FOR THIS PURPOSE. GAS METAL ARC (GMA) WELDING HAS ADVANTAGES OVER OTHER WELDING PROCESSES (I.E., LASER, ELECTION-BEAM, AND PLASMA ARC WELDING)… more
Abstract:THIS PROPOSAL ADDRESSES THE DEVELOPMENT OF A SET OF TECHNICAL SPECIFICATIONS FOR THE ESTABLISHMENT OF A LASER RADAR SEEKER HARDWARE-IN-THE-LOOP (HWIL) TESTING AND EVALUATION FACILITY. AEGIS RESEARCH WILL DETERMINE THE CAPABILITIES OF SEEKER UNITS ANTICIPATED TO BE TESTED BY SUCH A FACILITY,… more
Abstract:A CONCEPT FOR PASSIVE REMOVAL OF WATER FROM COMPRESSED AIR SUPPLY LINES IS PROPOSED. RELYING ON SURFACE TENSION EFFECTS TO REMOVE THE WATER, THIS CONCEPT IS FEASIBLE FROM A PRACTICAL STANDPOINT BECAUSE OF AN INVENTIVE MANUFACTURING APPROACH DEVELOPED BY ALABAMA CRYOGENIC ENGINEERING. THE PHASE I… more
Abstract:THE LONG-TERM OBJECTIVE IS TO DESIGN AND DEVELOP POTENT AND HIGHLY SPECIFIC INHIBITORS OF THE ENZYME ALDOSE REDUCTASE. ALDOSE REDUCTASE CATALYZES THE REDUCTION OF GLUCOSE TO SORBITOL. IT HAS BEEN IMPLICATED IN THE PATHOGENESIS OF THE CHRONIC COMPLICATI0NS OF DIABETES MELLITUS. CURRENT INHIBITORS OF… more
Abstract:THE LONG-TERM OBJECTIVE IS TO DEVELOP A SYNTHETIC PERICARDIUM FOR USE FOLLOWING OPEN HEART SURGICAL PROCEDURES, PARTICULARLY INVOLVING CARDIOPULMONARY BYPASS AND THE USE OF A TOTAL ARTIFICIAL HEART AS A BRIDGE TO TRANSPLANTATION. THE APPROACH UTILIZES A NEW CLASS OF BIOMATERIALS, ELASTOMERIC… more
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