Abstract:The primary objective for Phase I was to design and develop a proof of concept system demonstrating the basic functionality and feasibility to deploy technology in the field. During the six-month effort, a detailed Concept of Operations document was prepared that served as a foundation for the… more
Abstract:In this proposal, we have proposed a program for twenty months to build on the basic ideas and feasibility developed in Phase I of this SBIR in order to demonstrate the practical use of DSRC technologies with signal controller for adaptive timing with a goal towards commercialization.
Abstract:Our goal is to create a demonstrable software system that we call IntelliFusion, which fuses Connected Vehicle data with data from traditional inductive loop detectors and uses this data to improve traffic control at intersections across the country. Our work will improve the safety of… more
Abstract:Areas of research relating to self-healing composites structures have been undertaken by well-known and respected research institutions under the auspices of the Department of Defense. Patent literature and public technical communique describe their novel engineering approaches using polymeric… more
Abstract:Sensor development researchers and engineers have perpetually sought novel methods to reduce sensor size and improve performance. Continued miniaturization of sensors through micromachining has enabled novel applications and introduced new paradigms for engineered systems to interact with the world.… more
Abstract:DESCRIPTION: Significant increase in the efficiency and speed of MS-based tissue imaging (IMS) performed at atmospheric conditions using high-resolution mass spectrometer will have a profound impact on method applications to the entire analytical field ofcharacterization of biomarkers in tissues.… more
Abstract:E. coli are common bacteria and part of the normal flora of the GI tract. Some strains, including the Shiga toxin-producing E. coli (STEC) are able to produce a toxin (Shiga toxin), which can lead to serious human illnesses from mild diarrhea to life threatening conditions, such as hemolytic uremic… more
Abstract:The proposed SBIR research (Phase I and II) is devoted to developing a laser-based acousto-ultrasonic system for inspection of sealed containers. The system represents a promising technology for improving safety management in anti-terrorism and treaty compliance operations. The system will use a… more
Abstract:The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic… more
Abstract:Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more
Abstract:Agave BioSystems, with their academic partners at the Mote Marine Laboratory, proposes to develop probiotic pharmaceuticals from indigenous commensal microbes to enhance gastrointestinal health in the bottlenose dolphin (Tursiops truncatus). The dolphin gastrointestinal microbiome will be… more
Abstract:Wound management becomes increasingly challenging due to bacterial infections, especially from epidemic drug-resistant strains. To address this problem, Agave BioSystems proposes to develop a RANT (Rapidly Adaptable Nanotherapeutics) breadboard system built upon the modules successfully established… more
Abstract:DESCRIPTION (provided by applicant): The goal of the proposed project is to develop a commercial kit that will allow drug addiction researchers with ongoing projects using cell-based models to be able to successfully and conveniently produce human inducedpluripotent stem cells (iPSCs). Addiction to… more
Abstract:The objective of this project is to demonstrate the feasibility of a miniature, MEMS IMU based, accurate isolation and stabilization system for beam pointing of a laser designator. Inertial stabilization and relative attitude control are the two key elements constituting the proposed accurate… more
Abstract:The objective of this project is to provide the Office of the Secretary of Defense a landing zones determination system for small autonomous air vehicles. The AGNC approach involves the use of EO sensors to effect video data collection and processing for determination of scene constituent elements… more
Abstract:The core project objective is to demonstrate the Graphical Evolutionary Hybrid Neuro-Observer (GNueroObs) System in conducting complex system workflow analysis for visualizing the interaction between components and subsystems. This software tool provides a state-of-the-art systems analysis framework… more
Abstract:The objective of Phase II is to provide a device capable of measuring, correlating, and logging a wide range of dynamic events for external store carriages and that is accompanied by a mobile data retrieval/logging tool and base station analysis software. For achieving this, AGNC is providing the U… more
Abstract:The research objective of this proposal is to perform computational alloy development to enhance the Ti-6Al-4V chemistry for direct digital manufacturing (DDM). The new alloy will be designed to attain the following attributes: (1) isotropic behavior with mechanical properties on par with the upper… more
Abstract:The Phase II objective is to demonstrate the vision that the reuse of knowledge gained from known designs for Direct Digital Manufacturing (DDM) of building blocks in a laboratory can be leveraged in order to produce and rapidly qualify complex DDM parts whose geometry can be expressed as union of… more
Abstract:Successful adoption of open frameworks such as perfSONAR in Science DMZs within DOE labs, universities, and small-businesses, and the emerging trends of software-defined cloud platforms that inherently require multi-domain performance transparency are major drivers for a new market. However,… more
Abstract:DESCRIPTION (provided by applicant): This proposal responds to the action plan for combating the Silent Epidemic of Viral Hepatitis recently launched by the National Institutes of Health by focusing on early diagnosis of hepatitis, which is crucial for preventing further infections and to improve… more
Abstract:DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of vision loss in the United States. Unfortunately, there is no FDA-approved pharmacotherapy for DR. Current treatments in clinical practice and trails, such as laser… more
Abstract:This proposal addresses NASA's science objectives with innovative lidar architecture for atmospheric CO2 measurements. Specifically, the proposed work can support and potentially enhance the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) technologies. Using an active… more
Abstract:Aerospace structures are often subjected to a broad spectrum of mechanical and/or aerodynamic excitations and, therefore, there is a real need for the development of a modeling technique which can be used for the vibroacoustic analysis, with high fidelity and adequate spatial and spectral… more
Abstract:DESCRIPTION (provided by applicant): HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective anti-retroviral treatments. Cognitive impairments in the current treatment era are often mild and not readily detectable because currentscreening measures (e.g., the HIV Dementia… more
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