Abstract:DESCRIPTION (provided by applicant): Although numerous advances have been made in the treatment of severe hemorrhage, current blood plasma substitutes do not address new insights in resuscitation medicine. Research in fluid technologies and vascular response following significant pre-hospital… more
Abstract:Injuries to soft tissues in extremities represent a high percentage of battlefield wounds in recent conflicts. Therapies for restoring function to injured muscle are needed for Wounded Warriors suffering from debilitating and sometimes disfiguring musculoskeletal injuries. Regenerative medicine… more
Abstract:Skeletal muscle injury is a significant challenge to warfighters due to the severity of the injuries often caused by Improvised Explosive Devices. Currently, there are few viable clinical treatment options for these types of injuries. Keratin hydrogels offer a solution to these challenges as… more
Abstract:The improvement of body armor, equipment, and decreases in patient transport times have dramatically improved survival of combat injuries. However, data suggests that future conflicts will require more aggressive wound management at the point of injury to deal with more complex wounds particularly… more
Abstract:This Small Business Innovation Research Phase I project is focused on developing a one-piece functionally graded hybrid (fiber/particle) reinforced aluminum alloy matrix automobile brake rotor. Composite brake rotors have substantial weight savings potential, but costs and performance have limited… more
Abstract:REL has demonstrated that Squeeze Casting a is viable process for encapsulation of ceramic tiles for Warfighter protection systems. The SBIR Phase 1 has demonstrated that squeeze cast encapsulation can offer the following process attributes: a. Use of low tolerance as-pressed tiles, b. Control of… more
Abstract:This project develops and tests a multimedia software application to provide an independently usable format for improving knowledge of voting and election processes for persons with intellectual disabilities. During Phase I, a prototype is developed and evaluated to determine the feasibility of the… more
Abstract:This project develops a cloud-based system for managing and delivering “on demand” activity prompts to individuals with intellectual disabilities along with a comprehensive, automated reporting system to enable reliable remote notifications to facilitate monitoring of task compliance. Pictures,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project concerns the development of an optical fiber biosensor platform that achieves exceptionally high sensitivity through use of a nanoscale, high refractive index, self-assembled polymer coating on the cladding surface. A rapid, specific,… more
Abstract:Atmospheric aerosols influence the earths radiation balance through direct scattering and absorption of radiation, and through alteration in the formation, brightness and extent of clouds. The concentrations and size distribution of aerosols aloft is important to these effects. Needed is a method to… more
Abstract:ABSTRACT: The extreme toxicity of organophosphate (OP) chemical warfare agents (CWA) is due to their specific, rapid, and irreversible reaction with cholinesterase enzymes. A significant portion of this reactive nature of OP agents is directly due to the unique metabolically active environment… more
Abstract:Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there are still problems… more
Abstract:Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for… more
Abstract:One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting… more
Abstract:Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents… more
Abstract:With no clinically approved antiviral therapy available for treatment of flavivirus infections, the development of efficient vaccines and antiviral agents for prevention and treatment of infections is an urgent health priority. A combination of structure-based in silico models, in vitro and… more
Abstract:Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more
Abstract:Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… more
Abstract:A Neutron detection device is an indispensable tool for power, medical, defense, and homeland
security applications. The proliferation of weapons of mass destruction such as nuclear weapons
is a serious threat in today’s world. Low cost, low power, high performance, rugged and portable
Abstract:Agiltron proposes to develop an extremely compact and high sensitivity uncooled near- and mid-infrared (NMIR) spectrometer engine for planetary compositional analysis and mapping. In this program, we will produce lead salt-based IR detector materials with single crystalline-like oriented thin film… more
Abstract:Leveraging Agiltron"s industrial leading developments and production of high speed fiber optical components and modules as well as commercial photonic devices, we propose to develop a new class of high performance tunable RF filters and filter banks for advanced RF systems. The approach is… more
Abstract:ABSTRACT: In this STTR program, Agiltron and Iowa State University (ISU) jointly propose to develop simple material and structural solutions that enable directionally dependent emission in the infrared regime. The highly directional infrared emission has extremely narrow emission patterns and a… more
Abstract:ABSTRACT: Leveraging Agiltron"s organic thin film transistor (OTFT) array design and printing technology and industrial leading developments and productions uncooled mid-infrared (mid-IR) detectors and detector arrays, we propose to develop a new class of high performance printed mid-IR… more
Abstract:We propose to develop a device that is capable of rapidly identifying and classifying pollen from a broad sampling base using surface enhanced Raman spectroscopy (SERS). The proposed Raman device is designed to spectroscopically examine, identify and classify the spatial and temporal origin of… more
Abstract:Agiltron, in partnership with Worcester Polytechnic Institute (WPI), will build and test the Infrared Robotic Imaging System (IRIS), a stereoscopic vision system to provide 3-D location and mapping capability for the navigation of firefighting robotic systems. IRIS is based on Agiltron"s… more
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