Abstract:This Small Business Innovative Research (SBIR) Phase II project will further develop HunchLab -- software tools that leverage spatial statistics to enable police personnel to test their theories of criminality against data collected in the day-to-day activities of policing. The preceding Phase I… more
Abstract:DESCRIPTION (provided by applicant): Since the earliest examination of cellular structures, biologists have been fascinated by observing cells using light microscopy. The advent of fluorescent labeling technologies plus the plethora of sophisticated light
microscope techniques now available make… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will demonstrate the feasibility of a platform technology for cancer therapy which overcomes the inherent shortcomings of other attempts to delivery siRNA to cancer cells. The difficulty with current siRNA delivery is that the enzymes in… more
Abstract:This proposal will provide immediate decision support data, enabling appropriate and cost effective responses (shut down vs. continue) for training exercises/facilities. Specifically, the DoD requires the ability to "train as we fight and fight as we train", however training is severely limited by… more
Abstract:The development of affordable, high performance hearing protection and communication systems is critical for USAF and DOD aircraft maintainers who must work in the vicinity of jet exhaust noise during launch and recovery operations. Aegisound is in a unique position to leverage recently completed… more
Abstract:Rapid detection of the total trihalomethanes (TTHM) in treated drinking water is essential for compliance with the Environmental Protection Agency's (EPA) Stage 2 Disinfectants and Disinfection Byproducts (DBP) Rule, which limits the maximum contaminant level of TTHM in drinking water to 80 parts… more
Abstract:DESCRIPTION (provided by investigator): Lyme disease, caused by the gram-negative spirochete Borrelia burgdorferi and transmitted by Ixodid tick species, is the leading vector-borne infectious disease in the United States, with a steady rise in the number
of cases reported each year. The most… more
Abstract:The key to effective management of malaria is accurate diagnosis that is also rapid. The "gold standard" microscopy is time-consuming and labor-intensive and suffers from retirement of microscopic diagnostic experts and inaccurate slide reading. A field-deployable diagnostic method that is… more
Abstract:Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can… more
Abstract:Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and… more
Abstract:DESCRIPTION (provided by applicant): This project aims to develop talactoferrin (TLF, recombinant human lactoferrin) as a therapeutic agent to treat prematurely born neonates. The treatment will be given orally shortly after birth to prevent nosocomial inf
ections (NIs) due to abnormal bacterial… more
Abstract:DESCRIPTION (provided by applicant): Severe sepsis is a major cause of morbidity and mortality throughout the world. It is the leading cause of death in non-coronary intensive care units (ICUs) in the United States, with more than 750,000 cases occurring e
very year. This means that in the United… more
Abstract:The proposed Phase 2 project consists of the physical integration of our Phase 1 small, compact exciter with a "flight like" igniter or spark plug capable of hot-fire testing. The exciter/igniter unit will operate to a pre-established subset of expected flight performance requirements established… more
Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). The abnormal accumulation of neurotoxic brain ss-amyloid peptides (A?) is thought to be a possible cause the disease. A? are p
roduced by proteolytic cleavage of a larger… more
Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). Neurotoxic ?-amyloid peptides (A??) are thought to cause the disease with their accumulation in brain plaques being a hallmar
k. A? are cleaved from a larger amyloid… more
Abstract:Applied Media Analysis, Inc (AMA) proposes to collaborate with the George Washington University Weight Management Program and Peaksware LLC to demonstrate the technical feasibility of MobileVision DietMonitor, a software-based solution which uses existing
camera-enabled smart phones to provide… more
Abstract:We propose to develop a critical enhancement to an existing interactive task guidance system, integrating the capability to utilize data from sensors and control actuators. The system will allow caregivers or rehabilitation professionals to incorporate sensors and actuators into a task script in… more
Abstract:DESCRIPTION (provided by applicant): The main objective of this SBIR Phase I research is to develop and test a software prototype. The prototype will lead to a software product. It will be a clinical tool that helps clinicians to assess the condition of pa
tients who are at risk of or who have… more
Abstract:DESCRIPTION (provided by applicant): Indocyanine Green (ICG) and Sodium Fluorescein (SF) are fluorescent dyes used clinically in eye fundus imaging, primarily for detecting vascular abnormalities in the retina and choroid, which is the layer behind the ret
ina. It is used with the Heidelberg Retinal… more
Abstract:This Small Business Innovation Research (SBIR) Phase I Project addresses a crisis in the lack of effective glucose monitoring equipment for visually and cognitively impaired diabetics. The proposal thoroughly examines the technical and commercial feasibility of developing innovative technology that… more
Abstract:Currently, there is no standardized process for assessing the accessibility of recreation elements used for outdoor recreation, picnic and camping facilities although standards for specific outdoor recreation elements exist, the Forest Service Outdoor Recreation Accessibility Guidelines and the… more
Abstract:Cities must perform detailed assessments of sidewalks and streets, including curb ramps, pedestrian signals, crosswalks, street furniture, and other components to determine compliance with the Public Rights-of-Way Accessibility Guidelines. However, current assessment methods are inadequate or… more
Abstract:DESCRIPTION (provided by applicant): The CardioMetrix Endoluminal HF Monitoring System is intended to provide patients with ambulatory monitoring their heart function, allowing for better management of their disease and allowing them to live a life less en
cumbered by HF. The system uses ultrasound… more
Abstract:DESCRIPTION (provided by applicant): The long-term clinical objective of this proposal Multimodal Diagnostic and Therapeutic Nanoparticles for Non-Hodgkin's Lymphoma is the development of a novel therapeutic and diagnostic drug delivery technology for sp
ecific use in the treatment of… more
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