Abstract:Current methods used for the destruction of CW agents are cumbersome, require extensive capital equipment such as incinerators and water reactors and pose potential environmental problems themselves. A novel approach for the destruction of CW agents involves genetically engineering microorganisms… more
Abstract:Current technologies for marking of landing zones as well as areas for search and rescue have significant drawbacks ranging from the additional weight of batteries for some systems to plastic and metallic debris left behind. There are clear advantages both operationally and environmentally to… more
Abstract:In this Phase I, Agave BioSystems proposes to develop a catalytic organophosphorus bioscavenger based on human paraoxonase 1 (PON1) for the protection of personnel against OP nerve agents. A catalytic bioscavenger that detoxifies multiple organophosphorus (OP) molecules by hydrolysis rather than a… more
Abstract:Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Understanding how the body repairs damaged tissue and what genes and biochemical factors influence the wound healing process will have tremendous impact on the treatment of chronic wounds… more
Abstract:Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of… more
Abstract:Biofilms are ubiquitous in the environment. Few surfaces resist biofilm formation, most promote it. Biofilm formation poses problems in water systems as they can clog pipes and pores, block filters, reduce heat transfer, and in general restrict flow. Their metabolic products can aid corrosion,… more
Abstract:A PCR based assay has been developed to detect Leishmania parasites, but PCR requires sophisticated laboratory instruments and trained personnel to interpret the data. The parasite can also be identified in infected sand flies by skillful dissection and microscopic examination but this is… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this research is to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in Phase II clinical trials in patients with mild to moderate asthma.
Asthma is one of the most prevalent chronic inflammatory diseases in the… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a long-term, debilitating disorder that causes loss of memory and cognitive functions. There is an urgent need for effective therapeutic agents to ameliorate the symptoms of AD. Important molecular drug targets in AD are the… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project develops the concept of using hand-held, mobile devices to link the physical world to information networks using advanced pattern and symbol recognition technology that will be deployed on the mobile device. The proposed mobile… more
Abstract:DESCRIPTION (provided by applicant): The population of aging adults in the United States is entering a period of rapid growth as baby boomers get older and life expectancy continues to increase. One problem that is significantly affecting their ability to live and function independently is low… more
Abstract:DESCRIPTION (provided by applicant): To address wayfinding difficulties and physical activity among cognitively-impaired older adults, we propose to develop a navigation aid that can be attached to three- and four-wheeled rollators. The navigation aid will provide navigation assistance to the user… more
Abstract:DESCRIPTION (provided by applicant):
The time lapse 3D microscope imaging of living cells is widely used in many biomedical research areas. This technique potentially generates hundreds of image volumes in a single experiment, which are critical to the visualization and quantification of… more
Abstract:The Universal Trail Assessment Process (UTAP) and TrailWare, software for UTAP data, were developed to obtain objective trail information. Over 700 people within Federal, State, local and non-profit agencies have been UTAP trained throughout the US. Requiring 9 to 15 person hours per mile of trail… more
Abstract:DESCRIPTION (provided by applicant): There, is a high incidence of overuse injuries among manual wheelchair users. One method to prevent the development or delay the onset of injuries is to reduce the physical demand on the user during wheelchair propulsion. Configuration of the wheelchair can have… more
Abstract:DESCRIPTION (provided by applicant): People with disabilities have increased health risks as a result of a sedentary lifestyle. Limited access to fitness equipment is a primary barrier to physical activity and a significant environmental barrier to the health and well-being of people with… more
Abstract:People with mobility impairments are excluded from trails, shared-use paths, parks and other public areas where barriers are erected to prevent access by motorized trail vehicles (MTVs). To ensure the safety of trail users and the integrity of the natural environment, many recreation and/or… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project presents a new, non-contact method for sorting particles by size. The primary objective of Phase I activities is to evaluate the technical and commercial feasibility of a particle sorter based upon Aerodynamic Vectoring. This objective… more
Abstract:Chameleon Optics was founded on March 10, 1998 in Philadelphia, PA, for the purpose of developing unique devices based on proprietary chromogenic (color-changing) coatings. The company is a resident organization of the University City Science Center, one of the largest and most successful business… more
Abstract:Phase I work was targeted at investigation of a meteorological sensing package for unmanned aerial vehicles (UAVs). Much of this work was based upon operational experience gained during Cloud Cap Technology's involvement with numerous meteorological experiments which involved the use of small UAVs.… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase II SBIR proposal for a major extension to Cytel's flagship software, StatXact, to perform small sample exact inference for correlated categorical data. Such data are common in biomedical research, especially in areas such as genetics,… more
Abstract:DESCRIPTION (provided by applicant): The success and sensitivity of DNA detection is limited in important clinical, forensic, and environmental applications due to the presence of complex biological samples, such as blood, which reduce amplification efficiency. Different pre-PCR treatments that are… more
Abstract:ErisTech, a minority owned small certified defense contracting business based in San Diego, proposes a solution that will explore "best of breed" energy collection and storage techniques for surveillance airships in the stratosphere. Phase I work will consist of developing the most efficient power… more
Abstract:Successful completion of marketing and logistics research will provide post and pole plants in rural communities, forestland managers, and distribution businesses with critical understanding of the urban retail and wholesale marketplace and how best to position roundwood as a building, woodcraft and… more
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