Abstract:We will design a unique device that would clean and recirculate indoor air for the purpose of contrtuberculosis bacilli and other micro-organisms. The device would be based on the principle of particimpaction, a well-understood mechanism which is very effective for particles greater than 1… more
Abstract:We will research and develop a prototype for health care radio vignettes targeted specifically to Aadults. The prototype will be used as a model for the subsequent development of targeted health carebe packaged and sold as commercial media products for syndicated broadcast on radio stations… more
Abstract:We will develop commercial software which implements graphical and numerical methods for checking tadequacy of a variety of regression models frequently used in biomedical studies. In Phase I of theconcentrate on three popular models: the Cox proportional hazards model, the logistic regression… more
Abstract:A NOVEL HIGH-YIELD POSITRON SOURCE BASED ON COHERENT PAIR CREATION FROM THE COLLISION OF A HIGH POWER LASER BEAM WITH A HIGH ENERGY ELECTRON BEAM IS PLANNED FOR THIS PROJECT. THE LASER-PRODUCED POSITRONS HAVE A LOW TRANSVERSE EMITTANCE AND A NARROW SPECTRUM, PEAKING AT AN ENERGY MUCH BELOW THE… more
Abstract:Advances in dense sensor array measurement of brain electrical activity promise new insights into tthe human brain. This project develops Sourcerer(R), an innovative software package for distributedanalysis of Electroencephalographic (BEG) and Event-Related Potential (BRP) data. Whereas… more
Abstract:Diagnosis of neurological disorders such as epilepsy may soon be improved by the technical advancesarray magnetoencephalography (MEG) and electroencephalography (EEG) (Wikswo, et al. 1993). A relevanof rationed medical care is that the EEG is 10 to 100 times less expensive than the MEG or any… more
Abstract:We will develop a new low cost, data driven manufacturing technique for direct printing of micro-optical elements onto optical substrates and devices. We will apply our ink-jet printing technology to form and place microscopic droplets of optical materials, such as UV-cured resins and sol-gel… more
Abstract:This proposal concerns the development of a new method for etching, contouring, and cavitating teeth. The method consists of microdispensing a photoabsorptive dye onto the surface of tooth then focusing a laser beam on the dye spot, which is 75-200mum in diameter. By the appropriate choice of… more
Abstract:We will develop a computerized system for dietitians or other qualified health care professionals tdeveloping, implementing, and tracking nutrition and exercise interventions for modifying obesity anhypercholesterolemia. The computer-assisted nutrition and exercise program for professionals (CANE-Pa… more
Abstract:We will develop a computerized self- management program for hypertension. The computer-assisted nutexercise program for hypertension (CANE-H) will incorporate a hand-held computer (HHC) for structuriand a set of written support materials. The product will be unique because it incorporates the… more
Abstract:The importance of elucidating the mechanism(s) involved in iron metabolism is of great significance. The pathophysiological significance of oxygen free radicals and transition metal catalysis extends to any organ system and includes carcinogenesis including leukemia, coronary artery disease,… more
Abstract:Wild type (wt) dengue 1 viral RNA will be used as substrate to generate a complementary DNA (cDNA) library of clones that contain identified and sequenced DNA segments spanning the entire dengue 1 genome. Point mutations designed to generate amino acid alterations will be introduced at the… more
Abstract:With the recent isolation and identification of osteoclast progenitors and the isolation andpurification of osteoclast colony stimulating factor, new and exciting avenues of research can now beapproached. The development of chemically defined osteoclast hematopoietic reagents would be ofinestimable… more
Abstract:We will develop chemically defined reagents that support hematopoietic stem cell proliferation andSuch reagents would be valuable in hematological research especially for bone marrow transplantationex-vivo purging. Preliminary evidence indicates that it is feasible to replace the ill-defined and… more
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