Abstract:We will research and develop a prototype for health care radio vignettes targeted specifically to Aadults. The prototype will be used as a model for the subsequent development of targeted health carebe packaged and sold as commercial media products for syndicated broadcast on radio stations… more
Abstract:We will develop commercial software which implements graphical and numerical methods for checking tadequacy of a variety of regression models frequently used in biomedical studies. In Phase I of theconcentrate on three popular models: the Cox proportional hazards model, the logistic regression… more
Abstract:A NOVEL HIGH-YIELD POSITRON SOURCE BASED ON COHERENT PAIR CREATION FROM THE COLLISION OF A HIGH POWER LASER BEAM WITH A HIGH ENERGY ELECTRON BEAM IS PLANNED FOR THIS PROJECT. THE LASER-PRODUCED POSITRONS HAVE A LOW TRANSVERSE EMITTANCE AND A NARROW SPECTRUM, PEAKING AT AN ENERGY MUCH BELOW THE… more
Abstract:We will develop a new low cost, data driven manufacturing technique for direct printing of micro-optical elements onto optical substrates and devices. We will apply our ink-jet printing technology to form and place microscopic droplets of optical materials, such as UV-cured resins and sol-gel… more
Abstract:This proposal concerns the development of a new method for etching, contouring, and cavitating teeth. The method consists of microdispensing a photoabsorptive dye onto the surface of tooth then focusing a laser beam on the dye spot, which is 75-200mum in diameter. By the appropriate choice of… more
Abstract:The purpose of the antenna array is to serve radar, electronic support measure and electronics, electronic warfare and communications functions. Implicit in the multisystem function array is the need to operate many of these systems simultaneously. Additionally the array should be capable of… more
Abstract:The importance of elucidating the mechanism(s) involved in iron metabolism is of great significance. The pathophysiological significance of oxygen free radicals and transition metal catalysis extends to any organ system and includes carcinogenesis including leukemia, coronary artery disease,… more
Abstract:Wild type (wt) dengue 1 viral RNA will be used as substrate to generate a complementary DNA (cDNA) library of clones that contain identified and sequenced DNA segments spanning the entire dengue 1 genome. Point mutations designed to generate amino acid alterations will be introduced at the… more
Abstract:With the recent isolation and identification of osteoclast progenitors and the isolation andpurification of osteoclast colony stimulating factor, new and exciting avenues of research can now beapproached. The development of chemically defined osteoclast hematopoietic reagents would be ofinestimable… more
Abstract:We will develop chemically defined reagents that support hematopoietic stem cell proliferation andSuch reagents would be valuable in hematological research especially for bone marrow transplantationex-vivo purging. Preliminary evidence indicates that it is feasible to replace the ill-defined and… more
Abstract:The overall goal is to develop and market a high technology, dual-use product in the form of a system for efficient and cost effective production of reliable welded panels of the most promising of the existing titanium alloys. The system, called SWET, will have at its core an expert software system… more
Abstract:A number of biopharmaceutical companies have successfully taken hemoglobin-based oxygen carriers (Hinto phase I clinical trial. However, transfusions have been limited to low dosage levels due to obsvasoconstrictive effects at high dosage levels in pre-clinical animal studies. This proposal deals… more
Abstract:TLC Precision Wafer Technology, Inc. (TLC) has a very aggressive plan for becoming a leading manufacturer and supplier of epitaxial GaAs and InP-based wafers for military and commercial applications. Key to our strategy is to identify, develop, and be the first at market with those advanced… more
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