ABLE Kids II - Advanced Biofidelic Lower Extremity Kids Prosthesis II
Company: Orthocare Innovations, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): The Advanced Biofidelic Lower Extremity Kids prosthesis (ABLE Kids) project will advance the state-of-the-art of pediatric prosthesis systems by advancing the demonstrably successful Phase I device and refining it intoan ultracompact and lightweight form factor… more
Computerized Orthotic Prescription System - COPS
Company: Orthocare Innovations, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Stiffness and alignment of ankle-foot orthoses (AFOs) should be tuned optimally to maximize their function. Improperly tuned AFO may induce joint pain, reduced ambulatory function, and increased medical complications for patients with stroke. Therefore, the… more
Proactive Methodology for Identifying Problem Aerospace Parts
Company: ANAUTICS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ABSTRACT: The engineer will be guided through the creation of criteria, alternatives and evaluation techniques in order to make a better decision. BENEFIT: The engineer will be guided through the creation of criteria, alternatives and evaluation techniques in order to make a better decision.
Multi-Attribute Reliability and Maintainability Engineering Assessment Methodology
Company: ANAUTICS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: ABSTRACT: As we move from a paper-based world into a digital environment, the internet will soon evolve from a virtual documentation system into a vibrant ecosystem of data where documents and human actors play an even smaller role. We are currently reaching a tipping point in history concerning… more
Development of an Alternative Screening Method for Detecting Evidence of Mycobacterium Tuberculosis Infections
Company: Bijhem Scientific Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: This Small Business Innovation research Phase I proposes the development of a practical and reliable in-vitro test for detecting the evidence of Mycobacterium tuberculosis (MTB) infection as an alternative to the tuberculin skin test (PPD-TST) and to the interferon gamma release assays (IGRAs). The… more
A Small Molecule Targeting Wnt Pathway for Treatment of Diabetic Retinopathy
Company: CHARLESSON, LLP Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness. This sight-threatening condition has become a public health challenge in the US. Currently, there is no FDA- approved drugfor DR. Laser photocoagulation has remained… more
Identifying the drug target in dormant cancer cells
Company: DORMATARG, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): In spite of billions of dollars spent in the War on Cancer, cancer-specific mortality has changed little as a result, and the vast majority of cures are produced surgically, not from chemotherapy. The main problem is that even with early detection; most cancers… more
Development of an Anti-P-selectin Antibody for the Treatment of Sickle Cell Disea
Company: SELEXYS PHARMACEUTICALS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Selexys Pharmaceuticals is developing a humanized monoclonal antibody drug called SelG1 directed against P-selectin for the treatment of vasoocclusive crisis in patients with sickle cell disease. The ultimate goal of this Phase IIB proposal is to further advance… more
Defect Passivation for Improved Material Properties in Ga-free and Ga-based SLS
Company: Amethyst Research Incorporated Agency/Program/Year/Phase: DOD / STTR / 2012 / 1Abstract: A collaboration between Amethyst Research Inc., University Multispectral Laboratories (a government-owned, contractor-operated nonprofit corporation), and Teledyne Imaging Systems (a large defense contractor) proposes to develop/improve high-performance infrared sensors based on Type II,… more
The Use of Hydrogen for Defect Reduction in Large Format Infrared Detector Materials
Company: Amethyst Research Incorporated Agency/Program/Year/Phase: DOD / STTR / 2012 / 2Abstract: In Phase I we demonstrated a novel in-situ cleaning technique based on UV-activated surface reactions involving ozone and hydrogen to remove organic adsorbates and chemically-bonded impurities, e.g oxides, from the substrate surface. In Phase II the program will develop this process to… more
Low Dark Current, Extended Wavelength SWIR Sensors Using Hydrogenated nBn InGaAs
Company: Amethyst Research Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Improved performance SWIR sensors with extended wavelength response to 2.5 microns will be developed using two disruptive technologies with which Amethyst has demonstrated success: nBn detector structures and defect passivation via hydrogenation. Similar to conventional extended wavelength… more
High Pressure Open Channel Electroosmotic Pump
Company: Microchem Solutions Agency/Program/Year/Phase: DOE / STTR / 2012 / 2Abstract: The objective of lab-on-chip (LOC) is to integrate and perform multiple analytical processes on a microchip platform. So far, most LOC research has been focused on electrophoretic separations. Limited progress has been made on multi-process integration, due mainly to the lack of a robust and… more
Development of a Miniature Right Heart Support Device
Company: VADovations, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Congestive heart failure (CHF) is one of the most serious medical challenges of our day. With 5 million Americans compromised by the ravages of this disabling disease, CHF is the leading cause of Medicare hospital admissions. The economic burden exceeds 40… more
SBIR Phase I: Efficient structural mass from microstructural design
Company: MetCel LLC Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1Abstract: This Small Business Innovation Research Phase I project proposes high specific strength composite sandwich panels using a new form of manufacturing, tailored for Amorphous Metal Honeycomb (AMH) cores. Previously it was impossible to form these alloys as honeycombs since they do not behave like… more
Proactive Methodology for Identifying Problem Aerospace Parts
Company: VG Enterprises Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ABSTRACT: This proposal proposes to develop an agile methodology to identify bad actor parts to proactively address part performance. The methodology with algorithms and models will be developed by merging ideas from different areas of Science and Engineering. Some of the algorithms and models to… more
Terahertz Nondestructive Evaluation and Characterization of Missile Radomes
Company: Wavetech, LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: We propose to demonstrate the feasibility of using time domain terahertz measurements to locate, identify and image defects and material variations within advanced composite materials used in missile radomes. We will investigate the time and frequency domain transmission properties of radome… more
Antigen Immunoassay for Diagnosis of Coccidioidomycosis
Company: Immuno-Mycologics INC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Coccidioidomycosis, also known as Valley Fever, is a fungal disease caused by Coccidioides spp. that infects an estimated 150,000 people each year in the United States. Current diagnosis of coccidioidomycosis relieson detection of anti-coccidioidal antibodies… more
Point-of-care immunoassay for diagnosis of cryptococcosis in HIV/AIDS from whole blood
Company: Immuno-Mycologics INC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: Cryptococcal meningitis (CM) kills more than 600,000 HIV-infected individuals globally per year, with the highest yearly incidence occurring in sub-Saharan Africa. There is a critical need for a simple diagnostic tool for cryptococcosis that can be used in resource-limited countries. An innovative… more
Development HMTD-Containing Porous Materials as Non-Detonable Training Aids for Canines
Company: XploSafe LLC Agency/Program/Year/Phase: DHS / SBIR / 2011 / 2Abstract: The current practice of training canines for explosives detection utilizing actual explosives requires qualified personnel that are trained to handle
explosive materials making the training both manpower-intensive and costly. The expense is further exacerbated by the need to handle and dispose… more
Development of Microarrays-based Metagenomics Technology for Monitoring Sulfate-Reducing Bacteria in Subsurface Environments
Company: Glomics, Inc Agency/Program/Year/Phase: DOE / STTR / 2011 / 2Abstract: Due to their vast diversity and as-yet uncultivated status, detecting, characterizing and quantifying microorganisms in natural settings are of grand challenge, and understanding the mechanistic linkages between microbial diversity and ecosystem functioning and their feedback responses to human… more
Development of Novel Random Network Theory-Based Approaches to Identify Network Interactions Among Nitrifying Bacteria
Company: Glomics, Inc Agency/Program/Year/Phase: DOE / STTR / 2011 / 2Abstract: The interactions among different microbial populations in a community play critical roles in determining ecosystem functioning but very little is known about the network interactions in a microbial community due to the lack of appropriate experimental data and computational analytic tools.… more
SBIR Phase II: Commutational Ramp Load Disk Drive Actuator
Company: BLW Agency/Program/Year/Phase: NSF / SBIR / 2011 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project will design, build, test, and validate a fully operational prototype disk drive incorporating a commutational ramp load actuator (CRLA). The CRLA is a unique and transformative actuator for disk drives that provides significant… more
Multitargeted Therapy for Age-related Macular Degeneration
Company: CHARLESSON, LLP Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is a sight-threatening disease which represents the leading cause of blindness and visual impairment in elderly individuals in developed countries. Recently, laser and photodynamic therapies with limited clinical benefit… more
Novel emulsion-based formulation of the anti-glaucoma MSH-1001 for improved topic
Company: CHARLESSON, LLP Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): This Small Business Innovation project aims to develop an innovative eye drop formulation for the treatment of glaucoma and ocular hypertension. Charlesson has acquired from Danube Pharmaceuticals MSH-1001, a new smallmolecule compound (previously known as… more
Safety and Toxicology Studies of CLT-005 as a Therapeutic for Diabetic Macular Ed
Company: CHARLESSON, LLP Agency/Program/Year/Phase: HHS / SBIR / 2011 / 2Abstract: DESCRIPTION (provided by applicant): The objective of this proposal is to finalize development of CLT-005, a novel small molecule inhibitor of Stat3, through the performance of studies required for the submission of an investigative new drug application with the US Food and Drug Administration… more