Non-Enzymatic Cryogenic Isolation of Therapeutic Cells
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): In modern day medicine, cellular therapies, regenerative medicine and tissue engineering all involve technologies for harvesting, expanding, modifying and re-implanting live viable cells and tissues. Processes for preparing the therapeutic products that… more
Feasibility of immunotherapy by ice-free cryopreservation of engineered human all
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Autologous regenerative medicine tissue therapy costs are very high because when individual tissues are manufactured all the costs fall on a single patient. Allogeneic tissues are cheaper because large tissue batches can be made and the costs are shared by many… more
SBIR Phase I: Novel Connexin-Based Peptide for the Treatment of Age-Related Macular Degeneration
Company: FIRSTSTRING RESEARCH, LLC Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1Abstract: This Small Business Innovation Research (SBIR) Phase I project is a feasibility assessment of the ocular delivery of a synthetic peptide, ACT1, for the treatment of Age-Related Macular Degeneration (AMD). AMD is a retinal disease in patients who progressively lose their central vision through… more
Development of a novel connexin-based peptide for the treatment of corneal injury
Company: FIRSTSTRING RESEARCH, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): According to the World Health Organization, at least 171 million people worldwide are living with diabetes and this figure is likely to more than double by the year 2030. Because of its chronic nature, the severity of its complications and the means required to… more
Full Field, Out-of-Plane Digital Image Correlation (DIC) from Ultra-High Speed Digital Cameras
Company: Correlated Solutions, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: We propose to develop and implement a full-field, non-contacting deformation and strain measurement system capable of operating at frequencies above 1 MHz with unprecedented accuracy. The system will incorporate two ultra-high speed cameras in order to obtain three-dimensional shape and deformation… more
High Power Optical Amplifier (HPOAs) for Free Space
Company: KIGRE, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: ABSTRACT: Kigre proposes to develop and integrate unique radiation hardened, athermal, 1.5um laser gain materials and pumping architectures into high performance optical laser amplifier devices for SATCOM applications. The approach employs long life radiation tolerant pump diodes configured for… more
New High Performance Water Vapor Membranes To Improve Fuel Cell Balance of Plant Efficiency and Lower Costs
Company: TETRAMER TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOE / SBIR / 2012 / 2Abstract: This project targets improved efficiency and lower cost of proton exchange membrane fuel cells through the development of improved water vapor management. Fuel cells are highly efficient, non-polluting source of energy that can significantly decrease the US dependence on foreign oil while reducing… more
Development and Commercialization of Nanocomposite Coating Technologies
Company: TETRAMER TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOE / SBIR / 2012 / 1Abstract: There is a Global Safeguards need for tamper-indicating coatings of varying complexity for use in the verification and authentication of nuclear security documents, materials, and equipment. Current commercial coatings for seals used in this type of application lack the sophistication necessary for… more
SBIR Phase I: Commercialization of Innovative Low Refractive Index, High Temperature Perfluorocyclobutyl Polymers
Company: TETRAMER TECHNOLOGIES, LLC Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1Abstract: This Small Business Innovation Research Phase I project will determine the technical feasibility and the commercial value proposition of a high temperature fiber optic laser coatings for photonic crystal (PC) fiber lasers and large mode area (LMA) double-clad laser. Fiber lasers hold great potential… more
Commercial Development of Advanced UV Curable Index Matching Materials
Company: TETRAMER TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: In this Phase I SBIR program, Tetramer Technologies will develop new, commercially attractive, patentable, UV curable refractive index matching materials which have a significant shelf life in the uncured state. The value proposition to the customer working with fiber optic cabling will be increased… more
Development and Processing of Dielectric Films for Application in Large Wound Capacitors
Company: TETRAMER TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: There is currently a great need for commercially available dielectric films which can outperform biaxially oriented polypropylene (BOPP) at higher temperatures. While this need for such materials to improve the performance of high energy capacitors is well documented for pulse power applications… more
AlInN/GaN HFET over Free-Standing bulk GaN substrates
Company: Sensor Electronic Technology, Inc. Agency/Program/Year/Phase: DOD / STTR / 2012 / 2Abstract: This proposed research for Phase II consideration involves the growth of AlInN/GaN heterostructure field effect transistors (HFET) on bulk GaN substrates. By combining a homoepitaxial substrate for the growth of the heterostructures with the lattice-matching ability of the AlInN alloy, it is… more
Normally-OFF AlInN/GaN MISHFET with composite channel
Company: Sensor Electronic Technology, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: We propose to develop new key building blocks for next generation power electronics based on III-Nitride semiconductor technology. High-voltage, low-loss, normally-off III-Nitride insulated gate heterostructure field-effect transistor (MISHFET) is based on innovative and patent-pending… more
Ultraviolet Communication for Medical Applications
Company: Sensor Electronic Technology, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Deep ultraviolet LEDs will be developed and tested for customized application. Medical Communication system will be studied and prototyped with use of Solid State Components. Optical, thermal, electrical and data transfer characteristics will be investigated theoretically and experimentally
Targeting RNA conformation for drug development
Company: NUBAD, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for AIDS. Targeting specific RNA- protein… more
Online Training Support System for Community-Based Substance Abuse Agencies
Company: SHEIDOW CONSULTING, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Drug abusing and dependent youth represent a greatly under-served population at high risk of presenting significant deleterious long-term outcomes for themselves, their families, communities and society at extraordinary long-term costs. Adolescent substance use… more
Neuroprotective agents for retinal diseases
Company: MITOCHEM THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Retinal degeneration can be triggered by environmental insults as well as genetic mutations. The role for most disease genes is unclear and pathological processes are influenced environment making it difficult to identify one central cause. Indeed, the… more
A sample stabilization system for HIV in Plasma and Whole Blood
Company: ACXEND Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Nucleic acid analysis is the essential foundation of many biomedical research and diagnostic methods. Quantitative molecular diagnostic methods are critically dependent on the ability to stabilize the collected sampleprior to purification and analysis. While… more
Stroke Treatment by Chemically-Induced Hypothermia
Company: HALIMED PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / STTR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States. In spite of intensive investigations, clinical therapies for treating acute stroke patients remain limited and unsatisfactory. There are consistent animal and human data that mild to moderate… more
Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites
Company: CARBONIX, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induceasthma, especially in children. The focus of… more
SBIR Phase II: Hydrothermal Growth of Potassium Beryllium Fluoroborate (KBBF) for deep UV Nonlinear Optical Applications.
Company: ADVANCED PHOTONIC CRYSTALS, LLC Agency/Program/Year/Phase: NSF / SBIR / 2011 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project will develop a commercial growth process for single crystals of KBe2BO3F2 (KBBF) using hydrothermal techniques. The compound was developed 10 years ago and shows exceptional promise as a deep UV non-linear optical (NLO) material. The… more
Solvothermal growth of low-defect-density gallium nitride substrates
Company: ADVANCED PHOTONIC CRYSTALS, LLC Agency/Program/Year/Phase: DOD / STTR / 2011 / 1Abstract: ABSTRACT: This Small Business Technology Transfer Phase I project will address the problem of obtaining low-defect-density gallium nitride single crystals for substrates to enable low-defect, high-performance epitaxial growth. Gallium nitride is a very promising material for numerous applications… more
Feasibibility of deep hypothermic (18-22C) perfusion storage of livers for transp
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): More than 43,000 Americans die each year from liver disease, making it the 10th leading disease- related cause of death in the US. Cirrhosis with irreversible injury and scarring of the liver is the most prevalent causeof liver failure and is attributable to… more
Pancreas perfusion with PFC-Unisol
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): There is a worldwide consensus that islet transplantation may be considered a viable option for the treatment of insulin-dependent diabetes mellitus, and clinical trials are underway at many centers around the world. Asthis approach for curing diabetes… more
Perfusion Device for Lung Evaluation and Transplantation
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): Twenty four million Americans are affected with end-stage lung disease which is the 4th leading cause of death in the US, and there are currently 2,122 candidates on the lung transplant waiting list. Emphysema and chronic obstructive pulmonary disease are the… more