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Autonomously Locating to Perch and Stare (ALPS)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: Small Unmanned Air Systems (SUAS) are being developed for numerous applications, but size and weight constraints severely limit the capability and endurance of such vehicles. Many missions could be extended by landing for certain periods, entering a low-power state, and re-launching as needed,… more

Low Cost Small Sample Volume High Precision Carbon Dioxide Analyzer

Company: Li-cor Biosciences Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: LI-COR Biosciences proposes to develop a new sensor that measures the concentration of carbon dioxide in the atmosphere with precision of 1 part in 3000 within one minute, requires only small amounts of gas, operates unattended in the field for at least 6 months, costs less than $5000, and is… more

Improving Obesity Outcomes Through Interactive Web-Based Clinical Skills Training

Company: NATURE TECHNOLOGY CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): To commercialize non-viral gene medicines, it is critical that both vector potency (i.e. therapeutic transgene expression levels) and the duration of the therapeutic effect be improved. Potent dose-sparing extended duration gene therapies will have a cost and… more

Temperature-Tolerant COLD-PCR enables mutation-enriched targeted re-sequencing

Company: TRANSGENOMIC, INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Cancers develop from the life-long accumulation of critical somatic mutations due to DNA-damaging agents that lead to cells transforming into tumor-forming cells. These low-level tumor-associated somatic DNA mutations can have profound implications for… more

SBIR Phase I: Wise-Irr: Smart Irrigation via Wireless Underground Sensors

Company: Wildsense Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1
Abstract: This Small Business Innovation Research Program (SBIR) Phase I project investigates the feasibility of novel wireless underground communication technologies for real-time agriculture field monitoring to establish the proper timing and amount of irrigation for greatest effectiveness. Existing… more

IMPROVING THE TREATMENT OF CONTAMINATED AQUIFERS BYDEVELOPING DIRECT-PUSH OXIDAN

Company: AIRLIFT ENVIRONMENTAL, LLC Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION: Water quality is one of the biggest issues related to public health in the United States. Few situations incite more public outcry than when a community learns that their drinking water has been tainted. Two of the biggest threats to groundwater quality in the U.S. are contamination… more

SHARE Under Uncertainty

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / STTR / 2012 / 1
Abstract: In the GMD battlespace, it"s critical to rapidly ascertain specific identifying characteristics of a track so follow-on sensors can match the same track. Currently, sensors communicate track data with differing biases and uncertainties with little data-rich content and attempts to utilize track… more

Fusion with Uncertainty Reasoning using Nested Assessment Characterizer Elements (FURNACE)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Situation/threat modeling and threat prediction require higher levels of data fusion to provide actionable information to the warfighter. Beyond sensor data and sources the analyst has control over, the use of out-sourced and re-sourced data are becoming more common. However, the current data fusion… more

Self-Regulating Anomaly Detector (SeRADe)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Today"s intelligence exploitation has an information challengethere is a great deal of data being processed by a large number of analysts with insufficient ability to identify anomalies in the data. The process needs a capability that can facilitate a rapid understanding of complex information… more

Agent-Enabled Logistics Enterprise Intelligence System (AELEIS)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: Army logisticians and fleet managers need an effective method to extract actionable information from their large data stores. They need to extract root cause and case-based analysis to diagnose or predict breakdowns. An Enterprise Intelligence System that extracts data from multiple sources, fuses… more

Development of Ultrafine Particles for Intranasal Delivery of Antipsychotics

Company: LNKCHEMSOLUTIONS Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION: The goal of the proposed project is to develop a biocompatible ultrafine particle-based vector system for the intranasal delivery of clozapine for the pharmacological therapy of treatment- resistant schizophrenic disorders and their associatedsuicidal behavior. The rationale behind the… more

Early Detection of Pancreatic Cancer Using Ice COLD-PCR

Company: TRANSGENOMIC, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Ninety percent of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). PDAC diagnosis is difficult, usually occurring in the late stages of disease. Patients with these advanced tumors typically respondpoorly to therapy. Post diagnosis, median… more

Ex Vivo Tolerance for Xenotransplantation of Diabetes P2

Company: XIMEREX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Type I diabetes is a widespread disease in which insulin producing pancreatic islets are lost, leading to unstable glucose levels. If the islets can be replaced, as with transplantation, then diabetes can be reversed.Human islets have limited utility because of… more

Lightweight RSG Launcher Components and AURE Composite Cansiters

Company: Pacific Engineering, Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: NAVSEA Undersea Defensive Warfare Systems Program office is developing a Surface Ship Torpedo Defense program that utilizes Anti-Torpedo-Torpedo (ATT) hard kill capability for high value unit (HVU) platforms (Carriers and Combat Logistics Force (CLF) ships). The CAT, a hard kill countermeasure,… more

Lightweight RSG Launcher Components and AURE Composite Cansiters

Company: Pacific Engineering, Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: NAVSEA Undersea Defensive Warfare Systems Program office is developing a Surface Ship Torpedo Defense program that utilizes Anti-Torpedo-Torpedo (ATT) hard kill capability for high value unit (HVU) platforms (Carriers and Combat Logistics Force (CLF) ships). The CAT, a hard kill countermeasure,… more

RADIOGRAPHIC CONTRAST TO DIFFERENTIATE CAVITATED FROM NON-CAVITATED DENTAL CARIES

Company: FIREFLY HEALTH INNOVATIONS NE, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): This project relates directly to the PHS 2011-2, Omnibus Solicitation for SBIR/STTR Grant Application page NIDCR 110: Development of instrumentation for early caries detection and comparison studies on specificity andselectivity with respect to current clinical… more

SBIR Phase I: PET Radiotracer Synthesis

Company: Ground Fluor Pharmaceuticals, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1
Abstract: This Small Business Innovation Research Phase I project will support a new synthetic chemical approach for the creation of positron emission tomography (PET) imaging products to manage neurodegenerative disorders, cancer, and cardiovascular disease. Creating these imaging products relies on the… more

AMADEUS

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: ABSTRACT: Airspace congestion with RPAs in close proximity to manned systems poses a serious threat for mishap. At present, RPA pilot training in airspace management is minimal. RPA operator training should consider communications, asset management, deconfliction, and coordination among RPA and… more

Augur

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: History is replete with"intelligence failures"that were not intelligence weaknesses at all, but an inability to"put the pieces together"in time. Quintessentially, the 9/11 attack is an example, but it is merely the one most remembered. Pieces of intelligence were collected, like… more

Modular Video Interface for Intelligence, Surveillance, and Reconnaissance (M-VIISR)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: Intelligence, Surveillance, and Reconnissance (ISR) systems are diverse, and each one comes with its own interface to process and present imagery to the warfighter. When coupled with the complexities of processing multiple types of unmanned aerial vehicle (UAV) full motion video, it creates an… more

Measure and Alert on Data Omitted by Compression (MADOC)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: Critical information can be lost when lossy compression techniques are used in bandwidth limited environments, such as from unmanned systems. More serious, this lost information is unknown to the analyst, which can lead to incorrect analysis and potentially fatal conclusions. 21st Century Systems,… more

Smart Multimodal Image Registration and Fusion (SMIRF)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2011 / 2
Abstract: To improve safety, modern submarine surface imaging systems have multiple camera modes, such as optical, infrared, and more. Current systems display modalities independently, compelling the submariner to switch between sensors manually to glean the relevant information. Following a successful Phase… more

SBIR Phase II: Sample Classification and Biomarker Discovery by Comprehensive Metabolomic Analysis

Company: GC Imaging Agency/Program/Year/Phase: NSF / SBIR / 2011 / 2
Abstract: This Small Business Innovation Research Phase II project proposes to develop a system for automated classification of biological samples and discovery of biomarkers. The system will be designed to perform comprehensive pattern analysis of state-of-the-art biochemical separations generated by… more

Nanoparticles and Nanocapsules for Glioma Targeting

Company: LNKCHEMSOLUTIONS Agency/Program/Year/Phase: HHS / SBIR / 2011 / 2
Abstract: DESCRIPTION (provided by applicant): Malignant gliomas represent a heterogeneous family of tumors that are poorly responsive to current treatments. A major obstacle to the effective management of these lesions involves the difficulty in delivering adequateconcentrations of therapeutics to the tumor… more

eukaryotic expression vectors resistant to transgene silencing

Company: NATURE TECHNOLOGY CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2011 / 2
Abstract: DESCRIPTION (provided by applicant): Plasmid-directed gene expression is now near the efficacy barrier that to date has prevented commercialization of plasmid-based therapies for human health applications. Previous innovations such as electroporation (EP)increased transgene expression through more… more