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ENDOSCOPIC LIGHT SOURCE FOR PDT

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: PHS2001-2
Agency Tracking Number: 2R42RR012259-02A1
Amount: $278,132.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
508 HEARTWOOD RD CHERRY HILL, NJ 08003
CHERRY HILL, NJ 08003
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 RICHARD HSI
 (215) 346-5570
 HSI@XRT.UPENN.EDU
Business Contact
Phone: (609) 795-4560
Email: AMTINCOFDE@AOL.COM
Research Institution
 UNIVERSITY OF PENNSYLVANIA
 
UNIVERSITY OF PENNSYLVANIA
PHILADELPHIA, PA 19152
United States

 Nonprofit College or University
Abstract

DESCRIPTION (Verbatim from the Applicant's Abstract): We propose to continue to
develop and test a self-contained light delivery device for use in photodynamic
therapy (PDT) for Barrett's esophagus. This device employs distally located
semiconductor lasers at the end of a thin coaxial cable inserted into a balloon
catheter. In Phase I, we successfully developed prototype units that produced
sufficient light for PDT treatment and evaluated different scattering media to
increase the uniformity of the light emission. In Phase II, we intend to design
enhancements that produce uniform light distribution and increase the
illuminator's flexibility. A light and fluorescence detection system will be
incorporated into the balloon's wall. Unit will be tested for safety and
efficacy in an animal model. A significant advantage to this source design is
that individual segments or spot locations across the illuminator can be turned
on or off and the intensity changed during treatment. The light and
fluorescence detection systems will allow more uniform treatment and help
optimize treatment parameters (fluence, fluence rate, photosensitizer dose, and
photosensitizer/light interval) to maximize the PDT effect and minimize
toxicity. The diode illuminator will be capable of changing light dosing
parameters to fit optimal conditions for any situation including the use of
different photosensitizing compounds.

PROPOSED COMMERCIAL APPLICATION:
Not Available

* Information listed above is at the time of submission. *

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