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Advanced Platform of RNAi Technology

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66496
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
GM069369
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
9924 Mesa Rim Road SAN DIEGO, CA 92121-2910
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Advanced Platform of RNAi Technology
Agency: HHS
Contract: 1R43GM069369-01
Award Amount: $99,510.00
 

Abstract:

RNA interference (RNAi) is a powerful tool for gene function studies and drug development. Currently, application of this technology is largely limited by the efficiency of delivering RNAi-inducing reagents into mammalian cells. The aim of this proposal is to establish techniques to efficiently transfect siRNA-expressing cassettes. We have already developed a system to induce R NAi effects in mammalian I cells using novel DNA-based expression cassettes that offer gr eat advantages over other RNA or plasmid-based methods. We plan to take advantage of the unique design of our existing core technology by using transducing peptides as dell very vehicles. This will be particularly useful for RNAi-based gene silencing in traditionally hard to transfect cells such as primary cultures. T hese techniques can be further integrated into novel platforms for high throughput discovery and adapted for use in live animals. Development of these methods may also lay the foundations for exciting applications of our RNAi technology as therapeutic agents.

Principal Investigator:

Jiwu Wang
8585876645
JIWUWANG@ALLELEBIOTECH.COM

Business Contact:

Lin Wang
8583374718
LINWANG@ALLELEBIOTECH.COM
Small Business Information at Submission:

ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
ALLELE BIOTECH & PHARMACEUTICALS 6827 NANCY RIDGE DR SAN DIEGO, CA 92121

EIN/Tax ID: 522201071
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No