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Cell Microarrays for High Throughput RNAi

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65318
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA103580
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
9924 Mesa Rim Road SAN DIEGO, CA 92121-2910
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Cell Microarrays for High Throughput RNAi
Agency: HHS
Contract: 1R43CA103580-01
Award Amount: $99,510.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal of this proposal is to further develop and adapt our existing DNA-based RNAi technology to a cell microarray format for high throughput gene function studies and potential drug screening efforts. The principle of arrays of living cells for "reverse transfection" has been established and applied to identifying cDNAs involved in cellular physiology changes. We will first utilize the published cell microarray method for our DNA-based RNAi system to prove the principle of microarrays of RNAi (MAR). We will then use the method to screen for genes the silencing of which will alter the expression of a reporter gene. This high throughput format of RNAi will impact the gene analysis and drug screening fields tremendously. Once we have developed this technology, we plan to take advantage of our strong collaborations and high market demand to distribute our RNAi systems throughout the biomedical field.

Principal Investigator:

Jiwu Wang
8585876645
JIWUWANG@ALLELEBIOTECH.COM

Business Contact:

Lin Wang
8583374718
LINWANG@ALLELEBIOTECH.COM
Small Business Information at Submission:

ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
ALLELE BIOTECH & PHARMACEUTICALS 6827 NANCY RIDGE DR SAN DIEGO, CA 92121

EIN/Tax ID: 522201071
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No