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EFFICIENT CELL-FREE SELECTION OF ANTIBODIES

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 1R43CA089990-01
Amount: $99,700.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
5310 EASTGATE MALL
SAN DIEGO, CA 92121
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JIWU WANG
 () -
Business Contact
Phone: (858) 450-6616
Email: J8WANG@POPMAIL.UCSD.EDU
Research Institution
N/A
Abstract

DESCRIPTION: The objective of this proposal is to develop a novel cell-free
system that would facilitate rapid selection of functional fragments of
monoclonal antibodies. The system descibed is based on well-established
molecular mechanisms. For antibody selection, a cDNA library encoding the
single-chain variable region fragment (scFv) can be used in an in vitro
system to generate a large pool of scFv's that can be selected with target
antigens. The cDNA for the desired scFv can be recovered and used to express
large quantities of recombinant scFv. This procedure is more efficient, less
expensive and technically easier than all existing methods for antibody selection.
It also has the potential to be adapted to high throughput screening systems, or
modified to screen binding proteins other than antibodies.
PROPOSED COMMERCIAL APPLICATION:
The goal for the phase I studies is to test the feasibility of this innovative technology.
Once developed, it may have a major impact on proteomics, cancer diagnosis and drug
development.

* Information listed above is at the time of submission. *

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