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New Single Nucleotide Polymorphism (SNP) Scoring System

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 2R44HG001996-02A1
Amount: $652,055.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2810 MERIDIAN PKY, STE 152
DURHAM, NC 27713
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ROBERT HENKENS
 () -
Business Contact
Phone: (919) 544-8220
Email: JODALY@ANDCARE.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Identifying the roles of variable
individual genetic factors can revolutionize approaches to the diagnosis,
treatment, and prevention of human disease. Single nucleotide polymorphisms
(SNPs) are the most frequent DNA sequence variations that affect human health,
and better methods for scoring known SNPs in the human population are needed.
This SBIR project is designed to develop a sensitive, high-throughput,
efficient and affordable method of scoring known SNPs. Phase I work and
subsequent interim efforts have clearly established the feasibility of our
approach. The overall project goal is to develop an advanced electrochemical,
peptide nucleic acid (PNA) probe-based array system that can rapidly and
reliably measure SNPs. The electrochemical arrays will be developed within the
standard microtiter plate format, allowing researchers the ability to adapt
their existing automation instrumentation to this more-efficient
electrochemical platform.

This expanded, 3-year Phase II project will lead to 1) development of specific
PNA-based electrochemical sensor assays for the identification/quantification
of known SNP sequences; 2) design/fabrication of innovative sensor arrays and
appropriate array-reader instrumentation for high-throughput, accurate,
easy-to-use, and inexpensive SNPs scoring in human genomic samples; and 3)
demonstration, through collaborative studies, of the utility of this approach
to SNPs scoring for use by researchers and clinicians.
PROPOSED COMMERCIAL APPLICATION:
The new SNP scoring system proposed here is rounded on a versatile, automated chip-based system for probe analysis of DNA or RNA. It will serve as a companion instrument to PCR as well as a new tool for direct nucleic acid analysis. The laboratory market for PCR is currently $300 million per year. Our PCR related system would represent a significant new, complementary product in this marketplace. Furthermore, as the clinical market matures, we anticipate a range of diagnostic applications that will increase the opportunities for the instrument.

* Information listed above is at the time of submission. *

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