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Point-of-Care Diagnostic for Acute Q Fever using LAMP
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 2009Title: Point-of-Care Diagnostic for Acute Q Fever using LAMPAgency / Branch: DOD / ARMYContract: W81XWH-09-C-0036Award Amount: $70,000.00
Abstract:
Q fever is caused by the bacterium Coxiella burnetii and presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, however, can result in endocarditis, with a high mortality rate (up to 60% of chronic Q fever cases) and requiring open-heart surgery to repair substantial valve damage in many cases. Q fever can be airborne or tick-borne, and is associated with sheep and other livestock. Q fever is a significant factor in deployment conditions in Iraq and Afganistan. It is important to diagnose Q fever during its acute phase to direct appropriate treatment and to identify personnel requiring follow-up monitoring for chronic disease. While serology tests have been commercialized for Q fever detection, it is necessary to test both IgG and IgM against two types of Coxiella burnetii antigens to differentiate between acute and chronic disease stages. In addition, a high false positive rate occurs for these assays. To eliminate these shortcomings, Agave BioSystems proposes to modify a loop-mediated isothermal amplification (LAMP) reaction built into a point-of-care primitive field diagnostic device.Small Business Information at Submission:AGAVE BIOSYSTEMS, INC.
P.O. Box 100 Ithaca, NY 14850EIN/Tax ID: 161551819DUNS: N/ANumber of Employees:Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Defense |
Branch: Army |
Award ID: 92028 |
Program Year/Program: 2009 / SBIR |
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Agency Tracking Number: A083-178-0472 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |