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Xenopus Melanophore-Based Toxicity Sensor for Water

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
83258
Program Year/Program:
2007 / STTR
Agency Tracking Number:
A074-030-0323
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2007
Title: Xenopus Melanophore-Based Toxicity Sensor for Water
Agency / Branch: DOD / ARMY
Contract: W81XWH-07-C-0107
Award Amount: $99,999.00
 

Abstract:

Deployed armed forces often have to rely on water that is produced from decentralized sources, which presents significant difficulties for assuring the water is free of chemical toxicants. Analysis of these water supplies often requires complex instrumentation that is not practical for field use. An innovative alternative is the use of cell-based biosensors that can rapidly assess the general toxicity of the water sample and can be made field-portable. The use of living test organisms is a reliable way of measuring the biological impact or toxicity of unknown samples. Agave BioSystems has successfully demonstrated a broad-ranging water toxicity monitoring system using electrical impedance measurements across endothelial cell monolayers. While this system has proven sensitive to many chemicals of interest, the Army desires to extend detection capability to a broader class of toxicants including neurotoxins. Therefore, in collaboration with Dr. Vladimir Gelfand of Northwestern University and in consultation with Dr. Ethan Lerner of Harvard University, Agave BioSystems proposes to demonstrate that Xenopus melanophores can be used as a powerful field toxicity detection system for a wide variety of waterborne toxicants including neurotoxins.

Principal Investigator:

Theresa Curtis
Senior Scientist
6072720002
tcurtis@agavebio.com

Business Contact:

Noe Salazar
President
5126566200
nsalazar@agavebio.com
Small Business Information at Submission:

AGAVE BIOSYSTEMS, INC.
P.O. Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
NORTHWESTERN UNIV.
Rubloff Building 7th Floor
750 North Lake Shore Dr.
Chicago, IL 60611
Contact: Jamie Young
Contact Phone: (312) 503-7911
RI Type: Nonprofit college or university