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Detection of Explosive Materials Using an Encapsulated Fluorescent Bioprobe

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
77852
Program Year/Program:
2006 / STTR
Agency Tracking Number:
A064-025-0256
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2006
Title: Detection of Explosive Materials Using an Encapsulated Fluorescent Bioprobe
Agency / Branch: DOD / ARMY
Contract: W9132V-06-C-0027
Award Amount: $100,000.00
 

Abstract:

The use of explosives over the last 100 years has left up to 16,000 military ranges contaminated with highly toxic compounds. A major challenge to the remediation of these ranges is identifying the location of persistent explosive residues. To meet this challenge, Agave BioSystems in collaboration with Universities Space Research Agency (USRA) proposes to develop an encapsulated fluorescent bioprobe for detection of explosive materials. Encapsulation of the bioprobe will rely on porous silica nanoparticles, which will provide a matrix for the probe and enhance its environmental stability by allowing chemical agents of interest to enter while leaving the bioprobe impervious to other compounds and pH fluctuations. Detection will rely on a displacement immunoassay that results in fluorescence in the presence of explosives. Dye-labeled anti-TNT antibody fragments will provide fluorescence, and antibody fragments will be attached within porous silica nanoparticles. In the absence of TNT, the TNT quencher analogue will bind to the dye-labeled antibody fragments, preventing fluorescence. When TNT is present, the TNT quencher analogue will be displaced, removing the fluorescence quenching effect. The Phase I effort will focus on encapsulating the bioprobe and detecting 2,4,6-trinitrotoluene (TNT).

Principal Investigator:

Joel Tabb
6072720002
jtabb@agavebio.com

Business Contact:

Noe Salazar
President
5126711369
nsalazar@agavebio.com
Small Business Information at Submission:

AGAVE BIOSYSTEMS, INC.
P.O. Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITIES SPACE RESEARCH ASSOC.
USRA c/o The NCSER
Cleveland, OH 44135
Contact: Randy Vander Wal
Contact Phone: (216) 433-9065
RI Type: Nonprofit college or university