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Respiratory Endothelial Cell Sensor for Real-Time Air Toxicity Monitoring

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
68271
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
A032-3868
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
 
Phase 2
Fiscal Year: 2004
Title: Respiratory Endothelial Cell Sensor for Real-Time Air Toxicity Monitoring
Agency / Branch: DOD / ARMY
Contract: W81XWH-04-C-0043
Award Amount: $730,000.00
 

Abstract:

Because many chemical and biological toxins selectively target respiratory endothelial cells, a biosensor using these cells in combination with Electric Cell-substrate Impedance Sensing (ECIS) technology has many useful applications for detection and early warning monitoring of a broad range of toxic agents. In the Phase I SBIR program, Agave BioSystems was highly successful in demonstrating that endothelial cells are a robust system, which can be harnessed in a new class of extremely sensitive yet versatile biosensors to detect a wide variety of chemical toxins. Through simple monitoring of the integrity of respiratory endothelial monolayers using ECIS technology, we successfully detected paraquat, pentachlorophenol, and half-mustard contamination within minutes of addition to the biosensor. Additionally, by combining the respiratory endothelial cells with state of the art microfluidics we were able to continuously deliver samples to the biosensor and demonstrate real-time toxicity monitoring over a two-week period. The focus of the Phase II plan will be to test the system with a wide range of toxic chemicals, refine the microfluidic biochip for continuous flow conditions, develop a field portable ECIS biosensor and integrate an air sampling system for continuous monitoring.

Principal Investigator:

Theresa Curtis
Staff Scientist
6072720002
tcurtis@agavebio.com

Business Contact:

Noe Salazar
President
5126711369
nsalazar@agavebio.com
Small Business Information at Submission:

AGAVE BIOSYSTEMS, INC.
P.O. Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No