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Phage Array Biosensor for Detection of Biowarfare Agents

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
52987
Program Year/Program:
2001 / STTR
Agency Tracking Number:
A013-0055
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2001
Title: Phage Array Biosensor for Detection of Biowarfare Agents
Agency / Branch: DOD / ARMY
Contract: DAAD19-02-C-0017
Award Amount: $100,000.00
 

Abstract:

Agave BioSystems, in collaboration with Professor George Malliaras of Cornell University, proposes to develop a unique and innovative biosensor based on induced luminescence of captured BW bacterial agents and organic light emitting diode (OLED)technology. The system would use an array of bacteriophage engineered to express fluorescent protein in infected BW agents. The specificity of the phage provides capture of only targets of interest, while the infection of the bacteria and naturalreplication of the expressed protein will provide the detection signal. Using novel OLED arrays, a phage array chip can be constructed similar to DNA chips for multianalyte detection. The combination of the phage array approach with OLED detectionallows development of a powerful biosensing system that does not require additional labeling, sample manipulation, or sophisticated microfluidic and pumping mechanisms.Potential markets include the food processing, environmental, medical and agriculturalsectors. Relevant examples include the detection of Listeria monocytogenes in dairy foods and detection of multi-drug resistant bacteria in hospitals and clinics. All bacteria responsible for these outbreaks are susceptible to phage infection, and thus arelikely candidates for detection by the phage array biosensor.

Principal Investigator:

Tom Klem
Senior Scientist
6072558479
tklem@agavebio.com

Business Contact:

Noe Salazar
President
5126711369
nsalazar@agavebio.com
Small Business Information at Submission:

AGAVE BIOSYSTEMS, INC.
P.O. Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
CORNELL UNIV.
120 Day Hall
Ithaca, NY 14853
Contact: Linda Brainard
Contact Phone: (607) 255-7123
RI Type: Nonprofit college or university