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Fluorogenic Cell-Based Biosensors for Microbial Monitoring

Award Information

Agency:
National Aeronautics and Space Administration
Branch:
N/A
Award ID:
51642
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
NASA1597
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Fluorogenic Cell-Based Biosensors for Microbial Monitoring
Agency: NASA
Contract: N/A
Award Amount: $70,000.00
 

Abstract:

Great strides have been made in developing diagnostic systems for detecting and identifying specific pathogens and their toxins. However, these systems may be too specific and unable to detect newly emerging pathogens whose immunological or genetic profile is different than the normal complement of pathogens. The ideal system in an isolated environment such as a spacecraft would be one that provided a warning if any pathogen is present. In this Phase I effort, we propose to engineer chimeric proteins that fuse CD14 bacterial binding protein and the Fc portion of IgE antibodies. These novel bacterial receptors will bind to both mast cells and a large variety of pathogenic bacteria, enabling the mast cells to sense very low levels of contaminating bacteria from a diverse population. Using a compact yet highly sensitive fluorometer, this innovative biological receptor and signal transduction system will provide detection capability for a wide variety of pathogens in a single small and lightweight biosensor. This sensor will have applications in a number of testing regiments including being able to detect bacteria present in water, food, surfaces and the spacecraft air supply.

Principal Investigator:

Joel Tabb
Senior Scientist
6072558479
jtabb@agavebio.com

Business Contact:

Noe Salazar
President
5126711369
nsalazar@agavebio.com
Small Business Information at Submission:

Agave BioSystems, Inc.
PO Box 80010 Austin, TX 78708

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No