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Combination of GM-CSF with TKR gene therapy

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65319
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA099460
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANTAGENE, INC
ADVANTAGENE, INC 440 Lexington St Auburndale, MA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Combination of GM-CSF with TKR gene therapy
Agency: HHS
Contract: 1R43CA099460-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Combined gene therapy (Herpes Simplex Virus Thymidine Kinase + Anti-herpetic Prodrug) and radiation therapy (TKR therapy) is a novel approach in the armamentarium against cancer. This radio-gene therapy combination creates a new spatial co-operation whereby two local treatment modalities have demonstrated enhanced local and metastatic tumor control and prolongation of survival. We have taken TKR therapy into clinical studies and currently have more than 60 patients in a Phase II trial in prostate cancer. Our corporate strategy is to add novel therapies (gene therapy) with distinct, non-additive toxicity profiles to the standard-of-care (surgery, chemo- or radio-therapy) to enhance cancer cure or decrease treatment morbidity. TKR shows a potent systemic anti-metastatic effect, however, we believe this effect could be significantly enhanced by the addition of a cytokine that could further stimulate antigen presentation to the immune system. This Phase I application proposes to develop the reagents and single gene animal data to adequately evaluate the use of GM-CSF in combination with TKR.

Principal Investigator:

Madhu Chhikara
6179165445
MADHU_CHHIKARA@HOTMAIL.COM

Business Contact:

Estuardo Anguilar-cordova
6179165445
EAGUILARC@HOTMAIL.COM
Small Business Information at Submission:

ADVANTAGENE, INC.
ADVANTAGENE, INC. 160 PAULSON RD WABAN, MA 02468

EIN/Tax ID: 522214851
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No