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SBIR Phase I: Nanostructured Carriers for Delivery of Ciprofloxacin

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0320459
Agency Tracking Number: 0320459
Amount: $99,858.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2003
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
5385 Hollister Ave Ste 209
Santa Barbara, CA 93111
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Bret Coldren
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

This Small Business Innovation Research (SBIR)Phase I project proposes to test the feasibility of extended delivery of ciprofloxacin from a novel lipid drug delivery vehicle : the vesosome. Ciprofloxacin is a valuable antibiotic whose therapeutic index would be enhanced with an extended release vehicle. Ciprofloxacin remains stably encapsulated in conventional unilamellar liposomes during storage in buffer. However, ciprofloxacin is known to leak rapidly from conventional liposomes in vivo, even with optimized compositions, which limits the therapeutic benefits. This difference is believed to be due to membrane degradation by macromolecular serum components. Hence, fundamental stability advantages are expected in vivo with a multi-membrane vesosome. In this Phase I project, ciprofloxacin will be loaded into vesosomes by standard chemical gradient techniques and the formulation efficiency, stability during storage, and release rates (in serum) will be measured. If performance is found to be superior to optimized unilamellar liposomes, clinical development of vesosomal ciprofloxacin would follow.

The commercial application of this project will be in the area of drug delivery, particularly for delivery of ciprofloxacin. Therapeutic indications would include critical blood-borne infections, lung infections, and localized infections.

* Information listed above is at the time of submission. *

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