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System for comprehensive tracking and analysis of C. elegans behaviors

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
89127 		Program Year/Program:
2010 / SBIR
Agency Tracking Number:
ES017180 		Solicitation Year:
N/A 		Solicitation Topic Code:
NIEHS 		Solicitation Number:
N/A
Small Business Information
MICROBRIGHTFIELD, INC.
185 ALLEN BROOK LN, STE 201 WILLISTON, VT 05495-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: System for comprehensive tracking and analysis of C. elegans behaviors
Agency: HHS
Contract: 2R44ES017180-02
Award Amount: $744,130.00
 

Abstract:

DESCRIPTION (provided by applicant): We propose a commercial product composed of a computerized microscope system that allows investigators to perform automated, quantitative analyses of locomotory and other complex behaviors of freely moving C. elegans ne matodes. Using the soil nematode, C. elegans, as a practical and efficient model in toxicology studies requires creation of automated technologies to evaluate growth, size, reproduction, feeding, and movement under different experimental conditions. Curren tly, most methods to assess C. elegans phenotypic behavior are manual and laborious to perform which precludes medium-throughput studies. We believe that introduction of this robust commercial software solution will significantly contribute to further repl acement and reduction of conventional toxicology tests by alternative in vivo toxicology assays using C. elegans. PUBLIC HEALTH RELEVANCE: The proposed project will increase the throughput of studies involving quantitative behavioral analysis using the model organism Caenorhabditis elegans (C. elegans). This will allow researchers to automatically perform complex and laborious tasks which are presently performed manually. The overall effect of this project will significantly improve the productivity and effectiveness of research in such diverse fields as toxicology, environmental monitoring, ecology and neuroscience research.

Principal Investigator:

Jacob R. Glaser
8022889290
JGLASER@MICROBRIGHTFIELD.COM

Business Contact:

Jacob R. Glaser
susan@microbrightfield.com
Small Business Information at Submission:

MICROBRIGHTFIELD, INC.
MICROBRIGHTFIELD, INC. 185 ALLEN BROOK LN, STE 201 WILLISTON, VT -

EIN/Tax ID: 152160958
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No