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Ricin Toxin Protective Monoclonal Antibodies with Improved Serum Half-Life

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911QY-14-P-0232
Agency Tracking Number: A141-044-0278
Amount: $149,876.77
Phase: Phase I
Program: SBIR
Solicitation Topic Code: A14-044
Solicitation Number: 2014.1
Timeline
Solicitation Year: 2014
Award Year: 2015
Award Start Date (Proposal Award Date): 2014-12-11
Award End Date (Contract End Date): 2016-05-26
Small Business Information
6160 Lusk Blvd., Suite C105
San Diego, CA 92121-2740
United States
DUNS: 137551797
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Larry Zeitlin
 President
 (858) 625-0335
 larry.zeitlin@mappbio.com
Business Contact
 Kevin Whaley
Title: Business Official&CEO
Phone: (858) 625-0335
Email: kevin.whaley@mappbio.com
Research Institution
N/A
Abstract

Ricin is a category B toxin due to its ease of acquisition, dissemination, and the high potential for morbidity and mortality after exposure. There are currently no methods of preventing or treating ricin exposurethis represents a major unmet need for protection of civilians and warfighters. Because of their excellent safety profile and efficacy, mAbs are a rapidly growing class of therapeutic drugs with a regulatory track record superior to small molecules.The Mapp team, in collaboration with Dr. Nicholas Mantis (Wadsworth Institute, Albany, NY) has identified a highly potent humanized anti-ricin mAb, hPB10. The potency of this mAb is superior to any mAb previously described. In this work effort we propose to increase the serum-half life of hPB10 and establish proof-of-concept in rodent models with a long range objective of developing a safe, effective and long-acting mAb (> 6 months of protection from a single dose) product for ricin intoxication.The envisioned injectable product will be for use in humans both prior to (e.g. by first responders or military personnel entering a contaminated zone) and/or after ricin exposure.

* Information listed above is at the time of submission. *

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