Dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) have emerged as the most important arthropod-borne viral diseases of humans. There are four distinct dengue virus types (DEN-1, DEN-2, DEN-3, and DEN-4), each capable of causingdisease in humans. The conserved 3¿_-noncoding… More

Our phase 1 objective is to build a prototype immunochromatographic test device which is capable of detecting IgM and IgG antibodies specific for Orientia tsutsugamushi in blood, serum or plasma samples from soldiers or civilians. A filed use rapid assayto detect scrub typhus infection that is… More

Scrub typhus, caused by Orientia tsutsugamushi poses a threat to U.S. forces deployed to the Asian/Australian/Pacific regions during contingency and peacekeeping operations. Development of an assay for the detection of O. tsutsugamushi that is rapid, accurate, field-usable and soldier-friendly is… More

The first objective of Phase II is to validate the ready-to-use DNA-based dengue diagnostics kit under laboratory conditions using culture-derived dengue viruses as well as clinically confirmed dengue infected samples from different geographic origins. These prototype products will be developed for… More

Leishmaniasis has significant impact on military and civilian populations throughout the Asia-Africa region, including Afghanistan and Iraq. There are currrentlly no proper field-deployable diagnostic tools for the key form, cutaneous leishmaniasis. Development of an assay which detects cutaneous… More