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Encapsulation Technology for Increased Environmental Stability of Vertebrate Cells

Award Information
Agency: Department of Defense
Branch: Army
Contract: W9132T-14-C-0016
Agency Tracking Number: A2-5567
Amount: $528,095.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: A12-090
Solicitation Number: 2012.2
Timeline
Solicitation Year: 2012
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-04-21
Award End Date (Contract End Date): 2016-04-20
Small Business Information
1 Riverside Circle Suite 400
Roanoke, VA 24016
United States
DUNS: 000000000
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Blaine Butler
 Principal Investigator
 (434) 220-2509
 butlerb@lunainc.com
Business Contact
 Maggie Hudson
Title: Senior Contracts Administ
Phone: (434) 483-4254
Email: submissions305@lunainc.com
Research Institution
N/A
Abstract

Luna Innovations is developing stabilization technology for increased long-term storage of various biological moieties (e.g. enzymes, nucleic acids, and whole cells). This unique stabilization matrix allows for extended cell viability lifetime, minimizing cell maintenancerequirements while retaining physiological activity. The proposed encapsulated cell technology has been shown to provide significant improvements in cell lifetime, operational stability, with decreased maintenance requirements, and is easily integrated into a variety of sensing based platforms allowing for optical and/or electrical reporting metrics. During Phase I Luna demonstrated stable long-term cell viability with enhanced environmental stability for a variety of cell lines, including over 50 days for the fragile bovine lung microvessel endothelial cell line when stored at room temperature in ambient air. Phase II will focus on extending the cell viability and function for an increased variety of cell types while also working to integrate the stabilization technology into a microfluidic chip for incorporation into the SafePort water analysis system.

* Information listed above is at the time of submission. *

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