Non-invasive Detection System for Assessment of Oxidative Status

To address the Armys need for a non-invasive, compact, robust system to monitor the oxidative status of military personnel, ChromoLogic (CL) proposed and demonstrated during Phase I a OCular Oxidative Stress Monitor (OCOSMO) system based on non-invasive optical measurements of oxidative stress biomarkers that are expressed within the aqueous humor (eye). By building multiple generations of OCOSMO prototypes and performing in vitro tests, CL demonstrated for the first time that cost-effective non-invasive monitoring of oxidative stress biomarkers in real-time is highly feasible. A high specificity panel of biomarkers was identified for determining oxidative stress caused from exercise. Tests with the OCOSMO prototypes showed that these biomarkers can be identified with sensitivity >10x the clinical level needed. In Phase II, CL plans to develop a complete OCOSMO prototype and perform detailed pre-clinical and clinical validation of the technology.