Current techniques for real-time detection of signaling pathways in live cells are limited. Accacia International LLC, will develop better strategies by combining the signaling properties of molecular beacons and aptamer beacons with the advantages of quantum dot photoluminescence to produce… More

Accacia International LLC is a nascent biotech company, certified as a WBE/MBE, based in the heart of Texas and in the capital city of Austin. Accacia¿s scientists have provided consulting services and performed research work on SBIR projects in collaboration with other awardees, also developed… More

Accacia International has produced a potentially powerful system for the detection of a wide variety of biothreat agents. Accacia International proposes to design and prototype a compact, handheld fluorescence polarization based sensor capable of detecting biowarfare agents. Accacia International,… More

Aptamers have been selected against a variety of important biodefense targets, including protein toxins such as ricin and pepocin and antigens from pathogenic bacteria such as Yersinia spp. and F. tularemia. To ensure that reagents can be created for any of a variety of chemical and biological… More

DESCRIPTION (provided by applicant): Expanding use of microarray systems for global gene expression profiling is leading biological research, providing diagnostic and prognostic value to physicians and facilitating target discovery during drug and vaccine development. There is strong interest in… More

Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates… More

Nerve agents (NA) such as sarin, soman, tabun or VX are organophosphate compounds similar to those used as pesticides but with much higher toxicity that can cause death within minutes. Use of NA weapons of mass destruction has become a real threat since the Iraq-Iran war in the 1980s and the sarin… More

The World Health Organization estimates that more than one-third of the worldwide population is infected with Mycobacterium tuberculosis (MTB), the causative agent of most cases of tuberculosis (TB). Patients who are infected with MTB, but do not have active TB disease have latent tuberculosis… More