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Thermostable Sublingual Measles Vaccine Dry Wafers

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
200-2013-M-57610
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AKTIV-DRY
2100 Central Ave., Suite 109 Boulder, CO 80301-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: Thermostable Sublingual Measles Vaccine Dry Wafers
Agency: HHS
Contract: 200-2013-M-57610
Award Amount: $149,998.00
 

Abstract:

"Measles is a highly contagious, human disease that is spread by the respiratory route, and, in the developing world, remains a leading cause of death due to vaccine-preventable infectious diseases in children younger than 5 years. The most recent estimates are that there were 139,300 deaths worldwide in 2010 due to measles. Research priorities to help achieve the goals of controlling, and eventually eradicating, measles worldwide should include the development of thermostable alternative delivery methods to improve vaccine safety, effectiveness, and coverage. In this Phase I SBIR project, we aim to develop dry wafer formulations for sublingual administration that are thermally stable (Aim 1) and immunogenic (Aim 2). We will use Aktiv-Dryʼs patented CO2-Assisted Nebulization with a Bubble Dryer® (CAN-BD) technology to prepare dry powders of measles vaccine formulations containing novel excipients to enhance stability. These powders will then be processed into wafers. We anticipate the outcome of the proposed research will be the development of a dry wafer formulation that exhibits less than one log loss in measles vaccine virus titer after 6 months of storage at 37 °C. Furthermore, the sublingual vaccine wafers will clearly induce an immune response in cotton rats, an accepted model for measles research.

Principal Investigator:

Stephen Cape
(303) 350-3060
scape@aktiv-dry.com

Business Contact:

Alan Sims
Small Business Information at Submission:

AKTIV-DRY
2100 Central Ave., Suite 109 Boulder, CO 80301-

EIN/Tax ID: 752993463
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No