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Stratified Craniofacial Tissue Engineering Construct

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-10-C-0154
Agency Tracking Number: O093-H17-3169
Amount: $99,996.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: OSD09-H17
Solicitation Number: 2009.3
Timeline
Solicitation Year: 2009
Award Year: 2010
Award Start Date (Proposal Award Date): 2010-04-01
Award End Date (Contract End Date): 2010-10-31
Small Business Information
1 Riverside Circle Suite 400
Roanoke, VA 24016
United States
DUNS: 627132913
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Michael Danilich
 Principal Investigator
 (434) 220-0159
 submissions305@lunainnovations.com
Business Contact
 Maggie Hudson
Title: Contracts Administrator
Phone: (434) 483-4254
Email: submissions@lunainnovations.com
Research Institution
N/A
Abstract

While maxillofacial, head and neck structures compose approximately 12% of total body surface area, traditionally approximately 16% of battlefield injuries have involved the head and neck, with even higher percentages in the most recent conflicts. The head and neck have very complex anatomy. Battlefield injuries to this region tend to be “devastating and complex,” but are rarely life threatening. Susceptibility to infection is high, particularly when the mucosal lining of the oral cavity is disrupted and the deep structures of the face and neck become contaminated with bacteria-laden saliva. Because of many limitations of auto-, allo- and xenogenic tissues for definitive repair of traumatic battlefield injuries of the head and neck, Luna Innovations Incorporated proposes to demonstrate the feasibility of a stratified tissue engineering construct with well-defined molecular structure and microscale architecture, predictable properties and tailorable behavior. The construct will be biodegradable, antimicrobial, angiogenic, sterilizable, easily adapted to complex three-dimensional shapes and designed to regenerate adjacent, but different tissue types, such as bone and muscle. To minimize regulatory hurdles and manufacturing difficulties, the construct will not contain cells, proteins or vectors, but can easily be incubated with these or similar bioactive agents in the surgical suite immediately prior to implantation.

* Information listed above is at the time of submission. *

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