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KeraStat(TM) Burn Gel and Halofuginone to Prevent Scar Contracture after Burn…

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
H122-016-0242
Solicitation Year:
2012
Solicitation Topic Code:
DHP12-016
Solicitation Number:
2012.2
Small Business Information
KeraNetics, LLC
Richard Dean Research Building, Suite 168 391 Technology Way Winston-Salem, NC 27101-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: KeraStat(TM) Burn Gel and Halofuginone to Prevent Scar Contracture after Burn Injuries
Agency: DOD
Contract: W81XWH-13-C-0052
Award Amount: $149,834.00
 

Abstract:

This Phase I project is relevant to the ultimate goals of this program announcement given the prevalence of the IED which often creates complex burn wounds on the face and skin that often form hypertrophic scars that often contract over time. Burn wound healing is a complex process that includes phases of inflammation, granulation tissue formation, re-epithelialization, and, finally, remodeling. Our proposed solution intends to intervene during the wound healing and remodeling phase to prevent hypertrophic scars from forming, thereby preventing scar contracture. In this initial proof of concept study, a keratin burn product KeraStat Burn Gel and a keratin + halofuginone product (Halogel, halofuginone is a Type I collagen synthesis inhibitor) will be assessed for contraction prevention by a standard commercially available fibroblast contraction assay. Additionally inflammatory and matrix gene expression will be examined by RT-PCR array in fibroblasts and keratinocytes after keratin and halofuginone exposure. Together these data will form the basis for a Phase II large and small animal efficacy study in models of burn scar contracture.

Principal Investigator:

Luke Burnett
Chief Science Officer
(336) 725-0621
Luke.Burnett@KeraNetics.com

Business Contact:

Kim Westmoreland
Managing Director
(336) 725-0621
Kim.Westmoreland@KeraNetics.com
Small Business Information at Submission:

KeraNetics, LLC
Richard Dean Research Building, Suite 168 391 Technology Way Winston-Salem, NC -

EIN/Tax ID: 262789357
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes