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SBIR Phase I: Biosensors to Detect and Characterize Genotoxins

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
1214714
Solicitation Year:
2012
Solicitation Topic Code:
BC
Solicitation Number:
Small Business Information
Knudra Diagnostics
2500 South State Salt Lake City, UT 84115-3110
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2012
Title: SBIR Phase I: Biosensors to Detect and Characterize Genotoxins
Agency: NSF
Contract: 1214714
Award Amount: $149,930.00
 

Abstract:

This Small Business Innovation Research Phase I project creates GeniStress Responder. GeniStress Responder is part of EkaTox, a family of toxicology diagnostics harnessing the power of comparative genomics in nematodes to make toxicology predictions in humans. GeniStress Responder identifies and characterizes mutagenic and carcinogenic compounds (genotoxins) using bioengineered nematodes. Multiple types of bioengineered nematodes are created and arranged into a GeniStress Responder panel. The panel's bioengineered nematodes become biosensors of genotoxic activity. Each biosensor works by using a specific genotoxin-sensitive gene to drive expression of a fluorescent-protein coding sequence. Exposure to a specific genotoxin elicits a specific pattern of activity in the GeniStress Responder panel. Feasibility is demonstrated when known genotoxins create specific toxicogenomic responses in the GeniStress Responder panel. The broader/commercial impacts of this research are introduction of improved genotoxicity diagnostics in the marketplace. Current technologies are inadequate. No single test is available to comprehensively profile different types of sample genotoxicity. The market needs an easy-to-use test for genotoxicity profiling. GeniStress Responder fills the market need for genotoxicity profiling in one simple diagnostic kit. With GeniStress Responder, a toxic compound's mechanism-of-action is determined in a shorter time and with fewer resources, than what can be achieved with current technology. GeniStress Responder's ease-of-use will accelerate drug discovery (cancer therapeutics) and environmental toxicology testing (cosmetics, plastics, super-fund site cleanup).

Principal Investigator:

Christopher E. Hopkins
3852023854
chopkins@knudra.com

Business Contact:

Christopher E. Hopkins
3852023854
chopkins@knudra.com
Small Business Information at Submission:

Knudra Diagnostics
2500 South State Salt Lake City, UT 84115-3110

EIN/Tax ID: 454915070
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No